Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Compound: Mg2+

Synonyms: magnesium, Mg+2, Mg++, magnesium ion

Superclasses: an ion a cation

Component of:
MgCl2
MgADP
MgATP2-
magnesium sulfate heptahydrate
magnesium sulfate

Chemical Formula: Mg

Molecular Weight: 24.305 Daltons

Monoisotopic Molecular Weight: 23.9850419 Daltons

SMILES: [Mg++]

InChI: InChI=1S/Mg/q+2

InChIKey: InChIKey=JLVVSXFLKOJNIY-UHFFFAOYSA-N

Unification Links: ChEBI:18420 , ChemSpider:865 , HMDB:HMDB00547 , IAF1260:1787372 , KEGG:C00305 , PubChem:888

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -1.2482376 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

chlorophyllide a biosynthesis I (aerobic, light-dependent) , chlorophyllide a biosynthesis II (anaerobic) , chlorophyllide a biosynthesis III (aerobic, light independent) :
ATP + protoporphyrin IX + Mg2+ + H2O → Mg-protoporphyrin + ADP + phosphate + 3 H+

Reactions known to produce the compound:

chlorophyll a degradation I , chlorophyll a degradation III :
chlorophyllide a + 3 H+ → pheophorbide a + Mg2+

chlorophyll a degradation II :
chlorophyll a + 3 H+ → pheophytin a + Mg2+

In Transport reactions:
Mg2+[periplasmic space]Mg2+[cytosol] ,
Mg2+[periplasmic space] + ATP + H2O → Mg2+[cytosol] + ADP + phosphate + H+ ,
Mg2+[extracellular space] + ATP + H2O → Mg2+[cytosol] + ADP + phosphate + H+

Enzymes activated by Mg2+, sorted by the type of activation, are:

Activator (Allosteric) of: alkaline phosphatase aminopeptidase [Nakata79] , succinate-semialdehyde dehydrogenase [deCarvalho11] , N-acetylphosphatidylethanolamine-hydrolysing phospholipas [Wang06b] , inositol-1,3,4,5-tetrakisphosphate 5-phosphatase [Downes82] , isopentenyl-diphosphate delta-isomerase [Hahn96] , α-ribazole-phosphate phosphatase [Woodson06] , dimethylallyltranstransferase [Chen93a] , ω,E,E-farnesyl diphosphate synthase [Chen93a] , ω,E,E,E-geranyl-geranyl diphosphate synthase [Chen93a] , 2-phospho-L-lactate guanylyltransferase [Grochowski08] , pyruvate carboxylase [Mukhopadhyay et al., 1998] , phosphoenolpyruvate carboxylase [Patel04] , unsaturated CDP-archaeol synthase [Morii00] , geranylgeranylglycerol-phosphate geranylgeranyltransferase , phosphoglycerol geranylgeranyltransferase [Chen93b] , phosphorylase kinase [Farrar91] , phosphorylase kinase [Farrar91] , mannosylfructose-phosphate phosphatase [Torres07] , mannosylfructose-phosphate synthase [Torres07] , pseudouridine kinase [Preumont08] , trehalose synthase [Qu04] , acyl phosphate synthase [Lu06] , geosmin synthase [Jiang06] , germacradienol synthase [Cane03] , 6-carboxyhexanoate--CoA ligase [Ploux92] , halimadienyl-diphosphate synthase [Nakano05] , terpentetriene synthase [Hamano02] , terpentedienyl-diphosphate synthase , 3-demethylubiquinone-9 3-O-methyltransferase [Houser77] , ent-pimara-9(11),15-diene synthase [Ikeda07] , N-acetylhexosamine kinase [Nishimoto07] , CTP-dependent riboflavin kinase [Ammelburg07] , heptaprenyl diphosphate synthase [Sagami85] , α-D-glucose-1-phosphate cytidylyltransferase [Thorson94] , L-sorbosone dehydrogenase [Hoshino91] , 4-coumarate coenzyme A ligase [Loscher94] , aldehyde:NADP+ oxidoreductase [NavarroAvino99] , β-methyl-D-malate hydro-lyase (2-methylmaleate-forming) [Drevland et al., 2007] , malyl coenzyme A lyase [Hacking74] , 2-methylisocitrate lyase [Grimek03] , malonyl-CoA reductase [Alber06a] , malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming) [Hugler02] , β-methylmalyl CoA lyase [Herter02] , L-malyl CoA lyase [Herter02] , acetyl CoA carboxylase [Chuakrut03] , GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase [Albermann01] , allophanate hydrolase [Whitney70] , urea carboxylase [Whitney70] , 6-pyruvoyl tetrahydrobiopterin synthase [Takikawa86] , dihydroneopterin triphosphate pyrophosphohydrolase [Klaus05] , glucosyl-3-phosphoglycerate synthase [Costa07] , phosphoglucomutase [Accorsi89] , phosphoglucomutase , GDP-D-mannose pyrophosphorylase [Szumilo93] , GDP-D-glucose pyrophosphorylase [Szumilo93] , phosphomannose isomerase [Shinabarger91] , GDP-D-mannose pyrophosphorylase [Shinabarger91] , mannosyl-3-phosphoglycerate synthase [Empadinhas01] , mannosyl-3-phosphoglycerate phosphatase [Empadinhas01] , mannosylglycerate synthase [Martins99] , 5-methyl-2-oxo-3-hexene-1,6-dioate decarboxylase [He00] , 2-nitrophenol 2-monooxygenase [Zeyer88] , adenosylcobinamide-phosphate synthase [Blanche95] , pyruvic oxime dioxygenase [Ono96] , polyphosphate-dependent glucokinase [Tanaka03b] , glycerol-3-phosphate cytidylyltransferase [Park93] , glutathione synthetase [Nakagawa93] , ammonia-dependent carbamoyl-phosphate synthase [Pierson80] , pyruvate carboxylase [Mukhopadhyay00a] , ribulose bisphosphate carboxylase , argininosuccinate synthase [Raushel83] , trehalose-6-phosphate phosphatase [Klutts03] , 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [vanderOost02] , 5-oxo-L-prolinase [Williamson82] , 5-oxo-L-prolinase [Seddon85] , N-methylhydantoin amidohydrolase [Ogawa95] , propionate-CoA ligase [Horswill & Escalante-Semerena, 1999] , dihydroxyacetone kinase [Daniel95] , pyruvate kinase [Schramm00] , glucose dehydrogenase [Bonete96a] , 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [vanderOost02] , inositol monopohsphatase [Chen98a] , inositol monophosphatase [Chen99] , GDP-glucose trehalose-6-phosphate synthase [Elbein68] , α-phosphoglucomutase [Qian94] , β-phosphoglucomutase [Belocopitow74] , glucokinase [Hansen03] , ADP-glucose trehalose-6-phosphate synthase [Paschoalin89] , D-carnitine dehydrogenase [Setyahadi97] , poly(glycerol-phosphate) α-glucosyltransferase [Glaser64] , phenylacetate-CoA ligase [ElSaid00] , F420-0-glutamyl ligase [Li03b] , F420-1:γ-glutamyl ligase [Li03b] , γ-F420-2:α-L-glutamate ligase [Li03] , cob(I)yrinic acid a,c-diamide adenosyltransferase , LPPG:Fo 2-phospho-L-lactate transferase [Graupner02] , UDP-N-acetylmuramoylalanine--D-glutamate ligase [Walsh99] , diethylphosphate phosphodiesterase [Tehara03] , acetate kinase [Sagers61] , pyruvate kinase [Abbe83] , methylglyoxal oxidase [Rhee87] , D-xylose isomerase [Kawai94] , N-acetylmannosamine kinase [Banerjee69] , enolase [Kaufmann92] , citryl-CoA synthetase [Aoshima04] , 2-oxoglutarate carboxylase [Aoshima06]

Activator (Mechanism unknown) of: GDP-mannose 4,6-dehydratase [Sturla97] , ribose-phosphate diphosphokinase [HoveJensen86, Willemoes97] , acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase [Vallari82, Comment 1] , glutaminase B [Prusiner76] , D-mannonate oxidoreductase [Portalier72c] , adenylate kinase [Tan09a] , 6-phosphogluconate dehydrogenase [Comment 2] , tRNA(m5U54)methyltransferase [Ny88] , pyridoxamine-phosphate transaminase [BEECHEY57] , polyphosphate kinase [Ahn90, Haeusler92, Comment 3] , inorganic triphosphatase [Kohn12] , cyclic di-GMP phosphodiesterase [Lacey10] , EF-P-lysine lysyltransferase [Ambrogelly10] , benzodiazepinedione prenyltransferase [Yin09] , caffeoyl-CoA 3-O-methyltransferase [Ibdah03] , caffeoylglucose 3-O-methyltransferase [Ibdah03] , caffeate 3-O-methyltransferase [Ibdah03] , quercetin 3'-O-methyltransferase [Ibdah03] , gossypetin 8-methyl ester 3'-O-methyltransferase [Ibdah03] , gossypetin 8-O-methyltransferase [Ibdah03] , laricitrin 5'-O-methyltransferase [Ibdah03] , myricetin 3'-O-methyltransferase [Ibdah03] , patuletin 3'-O-methyltransferase [Ibdah03] , quercetagetin 6O-methyltransferase [Ibdah03] , quercetin 7-O-glucosyltransferase [Stich] , gossypetin 7-O-glucosyltransferase [Stich] , 4,6,8-trihydroxydibenzodiazepinone farnesyltransferase [Bonitz13] , cyanidin 3-O-glucoside 6"-O-rhamnosyltransferase [Kamsteeg80] , delphinidin 3-O-glucoside 6"-O-rhamnosyltransferase [Kamsteeg80] , cellobiose 2-epimerase [Taguchi08] , luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase [Schulz88] , luteolin 7-O-glucuronosyltransferase [Schulz88] , synephrine dehydratase [Manne86] , oleoyl-CoA:lysophosphatidate acyltransferase [Brown] , acyl-CoA:diacylglycerol acyltransferase [Sorger02] , mycinamicin III 3''-O-methyltransferase [Li09b] , cap1 methyltransferase [Belanger10] , mRNA guanylyltransferase [Itoh84] , thiamine diphosphate kinase [Voskoboyev87] , ecdysone 22-kinase [Sonobe06] , ginsenoside Rf 6-O-glucosidase [Wang11e] , ginsenoside Rh1 6-O-glucosidase [Wang11e] , ginsenoside Rg2 6-O-rhamnosidase [Wang11e] , ginsenoside Re 6-O-rhamnosidase [Wang11e] , ginsenoside Rg1 6-O-glucosidase [Wang11e] , ginsenoside R1 6-O-xylosidase [Wang11e] , protopanaxatriol-type ginsenoside with two glycosyl residues at position 6 6-glycosidase [Wang11e] , ginsenoside Rb1 20-O-glucosidase [Yu09] , ginsenoside Rb3 20-O-xylosidase [Yu09] , ginsenoside Rc 20-O arabinosidase [Yu09] , ginsenoside Rb2 20-O arabinosidase [Yu09] , protopanaxadiol ginsenoside 20-O-diglycoside glycosidase [Yu09] , 4-hydroxyphenylpyruvate dimethylallyl transferase [Steffensky98] , NADH kinase [Shi05c] , NAD(+) kinase [Shi05c] , NADH kinase [Kawai01] , NAD(+) kinase [Kawai01] , saturated archaetidylinositol phosphate synthase [Morii09] , hexanoyl-CoA synthetase [Stout12] , 4-coumarate:CoA ligase [Gaid12] , cinnamate:CoA ligase [Gaid12] , kaempferide 3-O-glucosyltransferase (F3GT2) [Ishikura94] , kaempferide 3-O-glucosyltransferase (F3GT1) [Ishikura94] , D-fructose-6-phosphate cytidylyltransferase [Wang12e] , phosphoenolpyruvate phosphatase [Tran10] , phosphoenolpyruvate phosphatase [Veljanovski06] , rhamnose 4'-O-methyltransferase [Kim10f] , rhamnose 3'-O-methyltransferase [Kim10f] , rhamnose 2'-O-methyltransferase [Kim10f] , spinosyn rhamnosyltransferase [Chen09] , UDPG:ginsenoside Rd glucosyltransferase [Yue05] , phosphatidate kinase [Wissing94] , phosphatidylinositol 4,5-bisphosphate lipase C [Melin92] , phosphatidylinositol 4-phosphate phospholipase C [Melin92] , PI(3,4,5)P3 5-phosphatase [Zhong04] , PI(3,4,5)P3 5-phosphatase [Zhong04] , PI(4,5)P2phosphoinositide 5-phosphatase [Zhong04] , Ins(1,4,5)P3 5-phosphatase [Zhong04] , Ins(1,4,5)P3 5-phosphatase [Zhong04] , Ins(1,4,5)P3 5-phosphatase [Zhong04] , D-xylulose-5-phosphate cytidylyltransferase [Wang12f] , chitotriose synthase [Keyhani96] , 3-phosphonopyruvate hydrolase [Kulakova03] , cholinephosphotransferase [Hjelmstad91] , glycerol-2-phosphate cytidylyltransfrase [Wang10e] , CDP reductase [Roshick00] , CDP reductase [Jordan97] , 7-methylxanthine demethylase [Gluck88] , peptidoglycan glycosyltransferase [Barrett05] , 4-dimethylallyltryptophan synthase [Unsold05] , diadenosine 5',5'''-hexaphosphate hydrolase [Safrany99] , bis(diphospho)inositol tetrakisphosphate phosphohydrolase [Safrany98] , 5-diphosphoinositol pentakisphosphate phosphohydrolase [Safrany98] , diadenosine 5',5'''-pentaphosphate hydrolase [Safrany99] , phosphatidylinositol 4,5-bisphosphate 5-phosphatase [Minagawa01] , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase [Minagawa01] , myo-inositol-3-phosphate monophosphatase [McAllister92] , myo-inositol-1-phosphate monophosphatase [McAllister92] , myo-inositol-4-phosphate monophosphatase [McAllister92] , myo-inositol-5-phosphate monophosphatase [McAllister92] , myo-inositol-6-phosphate monophosphatase [McAllister92] , phosphatidylinositol synthase [Antonsson94] , phosphatidylinositol-4,5-bisphosphate 3-kinase [Arcaro98] , unsaturated archaetidylinositol phosphate synthase [Morii09] , carboxyphosphonoenolpyruvate phosphonomutase [Hidaka90] , 2-keto-3-deoxy-D-glycero-D-galacto-nononate-9-phosphate synthase [Angata99] , L-galactose-1-phosphate phosphatase [Laing04] , iminodiacetate dehydrogenase [Uetz93] , vitexin β-glucosyltransferase [Heinsbroek80] , streptomycin 6-kinase [Sugiyama83] , 3-hydroxymethylcephem O-carbamoyltransferase [Brewer80] , phosphoserine phosphatase [Knox69] , tetrahydropteroyl-γ-polyglutamate:L-glutamate γ-ligase (ADP-forming) [Shane80] , glucuronokinase [Neufeld59] , N10-formyl-tetrahydrofolate:L-glutamate γ-ligase (ADP-forming) [Shane80] , feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase [Hohlfeld95] , gluconate dehydratase [Lamble04] , acetylpyruvate hydrolase [Davey & Ribbons, 1975] , dolichyl-phosphate mannose synthase [Haselbeck82] , glucuronokinase [Gillard78] , enolase [Miernyk84] , chitobiosyldiphosphodolichol β-mannosyltransferase [Sharma82] , methenyl-H4MPT cyclohydrolase [DiMarco86] , ethanolamine N-methyltransferase [Prudhomme92a] , ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6-diphosphotransferase [Rebeille97] , UDP-D-glucose pyrophosphorylase [Kotake04] , UDP-L-arabinose pyrophosphorylase [Kotake04] , UDP-D-glucuronate pyrophosphorylase [Roberts71] , mandelate racemase [WeilMalherbe66] , UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglocosaminephosphotransferase [Sharma82] , UDP-N-acetylglucosamine: dolichyl diphosphate N-acetylglucosamine, N-acetylglucosamine transferase [Sharma82] , (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase [Rebeille97] , galactokinase [Dey83] , enolase [Miernyk84] , amorpha-4,11-diene synthase [Mercke00] , amorpha-4,11-diene synthase [Chang00b] , 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Rohdich00] , 4-diphosphocytidyl-2C-methyl-D-erythritol synthase [Rohdich00a] , inosine-5'-phosphate nucleotidase [Bideon75] , 5'-AMP nucleotidase [Bideon75] , 5'-GMP-nucleotidase [Petritsch77] , acyl-CoA hydrolase (medium chain) [Alexson88] , quinolinate phosphoribosyltransferase (decarboxylating) [Mann74] , acyl-CoA hydrolase (short chain) [Alexson88] , cis-4-hydroxy-D-proline dehydrogenase [Yoneya61] , D-galactonate dehydratase [Szumilo81] , arabinose kinase [Neufeld60] , UDP-N-acetylglucosamine pyrophosphorylase [Szumilo96] , pelargonidin-3-O-glucoside-6''-O-rhamnosyltransferase [Kamsteeg80] , catechol O-methyltransferase [Rivett82] , molybdopterin molybdotransferase [Llamas06] , 2-ketogluconokinase [NARROD56]

Enzymes inhibited by Mg2+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: adenine phosphoribosyltransferase [Hochstadt78, Comment 4] , L-lysine monooxygenase [Nakazawa72]

Inhibitor (Mechanism unknown) of: imidazole glycerol phosphate synthase [Klem93] , UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase [Bartling08] , lipopolysaccharide glucosyltransferase [Qian14] , glutaminase [Brown08] , glutaminase [Brown08] , acetoacetyl-[acp] reductase [Price04] , dihydrofolate reductase [Baccanari75] , 5-methylaminomethyl-2-thiouridine-forming methyltransferase [Hagervall87] , 5-aminomethyl-2-thiouridine synthase [Hagervall87] , ribonucleoside-triphosphate reductase [Eliasson92, Comment 5] , RNase I endoribonuclease [Raziuddin79, Loskot78] , RNase I endoribonuclease [Raziuddin79] , Na+ / K+:H+ antiporter ChaA [Ivey93] , GTP cyclohydrolase [Weisberg86] , lyso-phosphatidylethanolaminelipase [Merkel05] , lyso-phosphatidylethanolaminelipase [Merkel05] , omega-hydroxypalmitate O-feruloyl transferase [Rautengarten12] , thiobenzoate-S-methyltransferase [Zhao12] , 1,2,4-trihydroxybenzene 1,2-dioxygenase [Takenaka03] , 4-oxalocrotonate tautomerase [Orii06] , NAD+-dependent L-rhamnofuranose 1-dehydrogenase [Rigo76] , oxalyl-CoA decarboxylase [Quayle63] , phosphatidate phosphatase [Wu96] , phenylacetyl-coenzyme A:glycine N-acyltransferase [Nandi79] , ε-N-trimethyllysine hydroxylase [Sachan80] , 27-O-demethyl-rifamycin SV methyltransferase [Xu03] , N-acetylpuromycin N-acetylhydrolase [Lacalle93] , histidinol dehydrogenase [Nagai91] , L-lysine-α-ketoglutarate reductase [Hutzler75] , benzoyl-coenzyme A:benzyl alcohol benzoyltransferase [DAuria02] , lysine N6-acetyltransferase [Bode93] , D-lactate dehydrogenase [Schweiger84] , hydrogenase [Schink79] , noradrenaline N-methyltransferase [Connett70] , δ-aminovaleramidase [Reitz70] , L-3-aminobutyryl coenzyme A deaminase [Jeng74] , glutamate synthase [Schreier84] , α-D-galactosyl-(1-3)-1D-myo-inositol:raffinose galactosyltransferase [Gaudreault81]

Inhibitor (Other types) of: D-sorbitol dehydrogenase [Yamaguchi94a]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: ATP synthase , acetolactate synthase , acetohydroxybutanoate synthase , acetohydroxybutanoate synthase , acetolactate synthase , UTP--glucose-1-phosphate uridylyltransferase , phosphoglucomutase , 3-isopropylmalate dehydrogenase , phosphoserine phosphatase , D-gluconate kinase , histidinol-phosphatase , imidazoleglycerol-phosphate dehydratase , farnesyl diphosphate synthase , geranyl diphosphate synthase , isopentenyl diphosphate isomerase , (E)-heptaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase , di-trans,poly-cis-decaprenyl diphosphate:isopentenyl-diphosphate undecaprenylcistransferase , carbamoyl phosphate synthetase , orotate phosphoribosyltransferase , CTP synthase , selenide, water dikinase , anhydro-N-acetylmuramic acid kinase , glucosamine-1-phosphate acetyltransferase , N-acetylglucosamine-1-phosphate uridyltransferase , UDP-N-acetylmuramate:L-alanyl-γ-D-glutamyl-meso-diaminopimelate ligase , UDP-N-acetylmuramate:L-alanyl-γ-D-glutamyl-meso-diaminoheptanedioate-D-alanine ligase , 4-hydroxybenzoate octaprenyltransferase , phosphatidylglycerophosphatase , phosphatidylglycerophosphatase , phosphatidylglycerophosphate synthase , nicotinate-mononucleotide adenylyltransferase , NAD+ synthetase, NH3-dependent , quinolinate phosphoribosyltransferase (decarboxylating) , NMN adenylyltransferase , L-rhamnulose kinase , tetraacyldisaccharide 4'-kinase , 3-keto-L-gulonate 6-phosphate decarboxylase , 3-deoxy-D-manno-octulosonate cytidylyltransferase , biotin-[acetyl-CoA-carboxylase] ligase , glycerate kinase , glyoxylate carboligase , malate synthase G , dTMP kinase , CMP kinase , o-succinylbenzoate-CoA ligase , o-succinylbenzoate synthase , isochorismate synthase , isochorismate synthase , 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase , thymidine kinase , 1,4-dihydroxy-2-naphthoate octaprenyltransferase , ribonuclease , phosphopantetheine adenylyltransferase , phosphopantothenoylcysteine synthetase , dihydroneopterin triphosphate 2'-epimerase , molybdenum cofactor guanylyltransferase , methionine adenosyltransferase , acyl carrier protein phosphodiesterase , holo-[acyl-carrier-protein] synthase , molybdenum cofactor cytidylyltransferase , asparagine synthetase , L-aspartate:L-glutamine amido-ligase (AMP-forming) , L-aspartate:ammonia ligase (AMP-forming) , anthranilate synthase , guanosine-5'-triphosphate, 3'-diphosphate pyrophosphatase , α-D-glucose-1-phosphatase , glucose dehydrogenase , fatty acyl-CoA synthetase , short chain acyl-CoA synthetase , glucose-1-phosphate adenylyltransferase , ribokinase , 1-phosphofructokinase , L-xylulose kinase , D-ribulokinase , L-fuculokinase , NAD kinase , glutamyl-tRNA synthetase , thymidylate synthase , acetylglutamate kinase , glycerol kinase , arginine decarboxylase, biosynthetic , adenosylmethionine decarboxylase , aspartate ammonia-lyase , 2-methylisocitrate lyase , adenine phosphoribosyltransferase , hypoxanthine phosphoribosyltransferase , inosine kinase , guanosine kinase , adenylosuccinate synthetase , adenylate kinase , thiamin monophosphate kinase , isocitrate lyase , succinyl-CoA synthetase , adenylylsulfate kinase , pyridoxal kinase , acetate kinase , propanoate:CoA ligase (AMP-forming) , acetyl-CoA synthetase (AMP-forming) , thiamine phosphate synthase , amidophosphoribosyl transferase , phosphoribosylformylglycinamide synthetase , phosphoribosylformylglycinamide cyclo-ligase , phosphoribosylglycinamide formyltransferase , arginyl-tRNA synthetase , valyl-tRNA synthetase , tryptophanyl-tRNA synthetase , L-serine:tRNASer ligase (AMP-forming) , phenylalanyl-tRNA synthetase , histidyl-tRNA synthetase , UDP-N-acetylmuramate-alanine ligase , UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase , transketolase , glutamate-putrescine ligase , dTDP-glucose pyrophosphorylase , pyruvate kinase , pyruvate kinase , 6-phosphofructokinase , phosphoenolpyruvate synthetase , fructose-1,6-bisphosphatase , α-dehydro-β-deoxy-D-glucarate aldolase , undecaprenyl-phosphate α-N-acetylglucosaminyl transferase , shikimate kinase , dethiobiotin synthetase , dihydropteroate synthase , 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase , 4-amino-4-deoxychorismate synthase , folylpoly-γ-glutamate synthetase , pantothenate synthetase , 2,3-dihydroxy-isovalerate:NADP+ oxidoreductase (isomerizing) , 3-methyl-2-oxobutanoate hydroxymethyltransferase , pantothenate kinase , 4-diphosphocytidyl-2C-methyl-D-erythritol synthase , 4-diphosphocytidyl-2-C-methylerythritol kinase , phosphoenolpyruvate carboxykinase (ATP) , malate dehydrogenase , trehalose-6-phosphate phosphatase , 6-phosphofructokinase , 2-oxoglutarate decarboxylase , 2-oxoglutarate dehydrogenase , pyruvate dehydrogenase , D,D-heptose 1,7-bisphosphate phosphatase , phosphoenolpyruvate carboxylase , glutamate-cysteine ligase , glutathione synthetase , galactokinase , 3,4-dihydroxy-2-butanone 4-phosphate synthase , GTP cyclohydrolase , tRNA nucleotidyltransferase , ATP-dependent DNA helicase , RNase D exonuclease , D-glucarate dehydratase , heme O synthase , DNA endonuclease , pyrophosphohydrolase , dihydroneopterin triphosphate pyrophosphohydrolase , guanosine-5'-phosphate phosphohydrolase , inosine-5'-phosphate phosphohydrolase , fructose-1-phosphatase , guanylate kinase , mannokinase , cellulose synthase , acetaldehyde dehydrogenase , xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) , Rnase , nucleoside triphosphate pyrophosphohydrolase , oxidized nucleoside triphosphate pyrophosphohydrolase , deoxyguanosine triphosphate triphosphohydrolase , DNA polymerase , DNA polymerase , DNA polymerase , gyrase , ADP-sugar pyrophosphorylase , RNase T exonuclease , GDP-mannose hydrolase , lactose galactohydrolase , pyruvate oxidase , McrBC restriction endonuclease , RNase BN exoribonuclease , γ-glutamyl kinase , 16S rRNA m62A1518,m62A1519 dimethyltransferase , 6-phosphogluconate phosphatase , tRNA(i6A37) synthase , peptidyl-tRNA hydrolase , DNA ligase , DNA ligase , citryl-ACP lyase , 16S rRNA m2G1207 methyltransferase , ribonuclease , adenylate cyclase , β-phosphoglucomutase , nucleoside di- and triphosphate hydrolase , 3' → 5' ssDNA exonuclease , 3'-nucleotidase , 5'-nucleotidase , adenosine-3'(2'),5'-bisphosphate nucleotidase , RNase R , exopolyphosphatase , DNA primase , lysyl-tRNA synthetase , glutathionylspermidine synthetase , CTP:2,3,4-saturated L-phosphatidate cytidylyltransferase , diacylglycerol kinase , sugar-phosphatase , sugar phosphatase , thiamin kinase , 1-deoxy-D-xylulose kinase , acyl-ACP synthetase , 2-acylglycerophosphoethanolamine acyltransferase , deoxyribonuclease I , ribonuclease , 10-formyltetrahydrofolate:L-methionyl-tRNAfMet N-formyltransferase , homoserine kinase , ADP-ribose pyrophosphatase , ribonucleoside-triphosphate reductase , NADH:ubiquinone oxidoreductase , lipoyl-adenylate--protein ligase , isocitrate dehydrogenase kinase , isocitrate dehydrogenase phosphatase , sugar phosphatase , UTP pyrophosphatase , dTTP pyrophosphatase , 2-keto-3-deoxy-L-rhamnonate aldolase , ribonucleoside-diphosphate reductase , [protein-PII] uridylyltransferase , D-malate dehydrogenase (decarboxylating) , FMN phosphatase , 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase , FMN phosphatase , 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase , enolase , polynucleotide phosphorylase , L-1-glycerophophorylethanolamine phosphodiesterase , glycerophosphoserine phosphodiesterase , glycerophosphoglycerol phosphodiesterase , glycerophosphodiester phosphodiesterase , acid phosphatase / phosphotransferase , ITPase , XTPase , 8-oxo-dGTP diphosphatase , phosphoglycolate phosphatase , 2,3-dihydroxybenzoate-AMP ligase , L-seryl-AMP synthase , inorganic triphosphatase , inorganic pyrophosphatase , phosphodiesterase, c-di-GMP-specific , GDP-glucose glucosyl hydrolase , GDP-mannose mannosyl hydrolase , tRNA m1G37 methyltransferase , glutamine synthetase adenylyltransferase , fructose 1,6-bisphosphatase , pyridoxal phosphatase , pyridoxal phosphatase , phosphosugar phosphatase , pyridoxal phosphatase , c-di-GMP phosphodiesterase , inositol monophosphatase , glycerol-2-phosphatase , xanthosine triphosphate pyrophosphatase , deoxyinosine triphosphate pyrophosphatase , inosine triphosphate pyrophosphatase , alkaline phosphatase , L-rhamnonate dehydratase , nucleoside diphosphate kinase , transport of a lipopolysaccharide , (R)-2,3-dihydroxy-3-methylbutanoate isomeroreductase , 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase , 2,4,6-octatrienoyl-2-amino-3-hydroxycyclopent-2-enone synthetase , 5-aminolevulinate-CoA ligase , leachianone G 2"-dimethylallyltransferase , biotin--[acetyl-CoA carboxylase] synthetase , naringenin 8-dimethylallyltransferase , 7-O-acetyl-N-acetylneuraminate synthase , L-α-amino acid ligase , L-α-amino acid ligase , L-α-amino acid ligase , L-α-amino acid ligase , 3-geranylgeranylindole synthase , cyclooctat-9-en-7-ol synthase , β-phosphoglucomutase , guanidinoacetate kinase , taurocyamine kinase , taurocyamine kinase , lombricine kinase , N-glutaminylanilide synthase , 1-deoxy-D-xylulose 5-phosphate reductoisomerase , lactenocin O-methyltransferase , macrocin O-methyltransferase , demethyllactenocin O-methyltransferase , demethylmacrocin O-methyltransferase , mycinamicin VI 2''-O-methyltransferase , anthranilate-CoA ligase , 2-methyl-4-hydroxyquinoline farnesyltransferase , L-2-aminoadipate--LysW ligase , oxaloacetate decarboxylase , NAD+-dependent malate dehydrogenase , eriodictyol 4'-O-methyltransferase , eriodictyol 3'-O-methyltransferase , quercetin 3'-O-methyltransferase , luteolin 3'-O-methyltransferase , caffeoyl-CoA O-methyltransferase , 4-coumarate--CoA ligase , 3-isopropylmalate dehydrogenase , diacetyl reductase [(S)-acetoin forming] , pyruvate kinase , hydroxymethylglutaryl-CoA synthase , mRNA 5′-triphosphate phosphatase , sucrose-phosphate phosphatase , sucrose phosphate phosphatase , sucrose phosphate synthase , pyridoxal phosphate phosphatase , phosphocholine phosphatase , ethanolamine phosphate phosphatase , decarbamoylnovobiocin carbamoyltranferase , 8-demethylnovobiocate synthase , dTDP-4-dehydro-5-methyl-L-rhamnose 4-ketoreductase , 8-hydroxy-7-methoxyflavone methyltransferase , 7,8,4'-trihydroxyflavone methyltransferase , cirsiliol 3'-O-methyltransferase , luteolin 3'-O-methyltransferase , 7,8,4'-trihydroxyflavone methyltransferase , 2,3,4-saturated fatty acyl-CoA ligase , phosphoribosylpyrophosphate amidotransferase , 2-oxoacid:ferredoxin oxidoreductase , pyruvate:ferredoxin oxidoreductase , 2-oxoglutarate:ferredoxin oxidoreductase , flavin transferase , 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase , dihydroneopterin aldolase , 2-dehydro-3-deoxygluconokinase , 2-dehydro-3-deoxygalactonokinase , phosphoribosylformylglycinamidine cyclo-ligase , phosphoribosylglycinamidine synthetase , GMP kinase , dGMP kinase , AMP kinase , dGTP phosphohydrolase , 8-oxo-dGTP phosphohydrolase , dTTP phosphohydrolase , dUTP phosphohydrolase , dCTP phosphohydrolase , dATP phosphohydrolase , GTP phosphohydrolase , nucleoside triphosphate phosphohydrolase , CTP phosphohydrolase , ATP phosphohydrolase , UTP phosphohydrolase , dCMP deaminase , dCTP deaminase , 2'-deoxyadenosine kinase , 2'-deoxyguanosine kinase , uracil phosphoribosyltransferase , 2'-deoxycytidine kinase , 2'-deoxyadenosine kinase , 2'-deoxycytidine kinase , 2'-deoxyadenosine kinase (ATP) , 2'-deoxyguanosine kinase (ATP) , dUTP diphosphatase , deoxyuridine 5'-triphosphate nucleotidohydrolase , inosine diphosphate phosphatase , deoxyinosine diphosphate phosphatase , 8-oxo-guanine diphosphate phosphatase , 8-oxo-deoxyguanine diphosphate phosphatase , 8-oxo-deoxyadenine diphosphate phosphatase , CMP-legionaminic acid synthase , 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase , 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase , 2-methylisoborneol synthase , geranyl diphosphate 2-C-methyltransferase , methylmalonyl-CoA epimerase , germacrene A synthase , germacrene A synthase , potchoulol synthase , patchoulol synthase , β-farnesene synthase , (E)-β-farnesene synthase , chrysanthemyl diphosphate synthase , 4-coumarate-CoA ligase , N,N'-diacetylbacillosaminyl-diphospho-undecaprenol α-1,3-N-acetylgalactosaminyltransferase , N,N'-diacetylbacilliosaminyl-1-phosphate transferase , [BtrI acyl-carrier protein]--L-glutamate ligase , 4-amino butanoyl-[BtrI acyl-carrier protein]--L-glutamate ligase , UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase , neamine phosphoribosyltransferase , 2-oxopent-4-enoate hydratase , 4-oxalocrotonate decarboxylase , UDP-glucose pyrophosphorylase , trehalose-6-phosphate phosphatase , chitin synthase , (-)-bornyl diphosphate synthase , (+)-bornyl diphosphate synthase , trehalose-6-phosphate phosphatase , hydroxymethylglutaryl-CoA lyase , 4-hydroxybenzoate-nonaprenyl transferase , 2-oxoglutarate decarboxylase , 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase , glucosamine kinase , pentalenene synthase , hydroxyethylthiazole kinase , phosphoenolpyruvate mutase , phosphoenolpyruvate mutase , tRNAHis guanylyltransferase , tRNAHis adenylyltransferase , tRNAHis guanylyltransferase , phosphatidyl-N-methylethanolamine N-methyltransferase , choline kinase , trans-α-bergamotene synthase , S-adenosyl-L-methionine-dependent dTDP-N-monodesmethyl-D-forosamine 4-N-methyltransferase, , sulfoacetaldehyde acetyltransferase , isochorismate synthase , homoserine kinase , UDP phosphatase , UDP phosphatase , CTP triphosphatase , CDP-diacylglycerol:myo-inositol phosphatidyltransferase , CTP:ethanolaminephosphate cytidylyltransferase , CTP:ethanolaminephosphate cytidylyltransferase , aristolochene synthase , trichodiene synthase , nitrogenase , nitrogenase , nitrogenase , 5-epi-aristolochene synthase , dimethylsulfide monooxygenase , phosphoglucomutase , cyclodextrinase , cyclodextrin glucanotransferase , malate synthase , 2-keto-3-deoxy-L-rhamnoate aldolase , tRNA-queuosine β-mannosyltransferase , oxaloacetate acetylhydrolase , oxalyl-CoA decarboxylase , 4-hydroxy-4-methyl-2-oxoglutarate aldolase , glucosylglycerate synthase , acetophenone carboxylase , (3S)-(E)-nerolidol synthase , α-gurjunene synthase , (-)-γ-cadinene synthase , shikimate kinase , shikimate kinase , epicedrol synthase , 3-hydroxyacyl-CoA-acyl carrier protein transferase , (S)-β-macrocarpene synthase , farnesyl diphosphate phosphatase , L-erythro-3-hydroxyaspartate aldolase , 5-chloro-5-deoxy-D-ribose 1-dehydrogenase , octadecanyl-[acp] reductase , guanine phosphoribosyltransferase , hypoxanthine phosphoribosyltransferase , acylating sulfoacetaldehyde dehydrogenase , adenosine kinase , sulfoacetate-CoA ligase , α-ketoglutaryl-diaminobutyryl-citryl-ethanolamine synthetase , diaminobutyryl-citryl-ethanolamino-α-ketoglutarate synthetase , α-ketoglutaryl-diaminobutyryl-citryl-ethanolamine:α-ketoglutarate ligase , diaminobutyryl-citryl-ethanolamino-α-ketoglutarate:α-ketoglutarate ligase , O-citryl-ethanolamine:diaminobutyrate ligase , citrate:ethanolamine ligase , citrate:serine ligase , dTMP kinase , dTDP kinase , dUTPase , pyrophosphate-dependent phosphofructkinase , geranylgeranyl-diphosphate tri-trans,poly-cis-undecaprenyl-diphosphate synthase , (2Z,6E)-farnesyl diphosphate mono-trans,poly-cis-dodecaprenyl diphosphate synthase , E,Z-farnesyl diphosphate synthase , geranylgeranyl-diphosphate hexaprenyl diphosphate synthase , methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase , methanol dehydrogenase , D-glucarate dehydratase , 3-deoxy-D-manno-octulosonate kinase , glucuronokinase , 4-coumarate coenzyme A ligase , 3-dehydroshikimate dehydratase , 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate phosphatase , ω,E,E-farnesyl diphosphate synthase , 5-phospho-α-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase , decaprenyl-N-acetyl-α-D-glucosaminyl-pyrophosphate:dTDP-α-L-rhamnose rhamnosyltransferase , hypoxanthine phosphoribosyltransferase , guanine phosphoribosyltransferase , mono-trans-poly-cis-nonaprenyl-cis-transferase , IMP 5'-nucleotidase , AMP 5'-nucleotidase , oxaloacetate β-decarboxylase , N-(4-hydroxybenzoyl)-L-glutamate synthetase , L-dopa O-methyltransferase , O-phosphoseryl-tRNA[Ser]Sec kinase , N-citryl-spermidine:spermidine ligase , 3,4-dihydroxybenzoyl-citryl-spermidine:spermidine ligase , D-proline reductase , ω,E,E-farnesyl diphosphate synthase , dimethylallyltransferase , isoprene synthase , elisabethatriene synthase , 4-chlorobenzoate:coenzyme A ligase , 4-oxalocrotonate decarboxylase , γ-glutamylhistamine synthetase , homoserine kinase , isopentenyl-diphosphate δ-isomerase , 5-formaminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5'-monophosphate synthetase , 3,4-dihydroxy-2-butanone 4-phosphate synthase , riboflavin synthase , GTP cyclohydrolase , creatine kinase , creatine kinase , creatine kinase , creatine kinase , creatine kinase , S-adenosylmethionine synthetase , cytidine 5'-monophosphate N-acetylneuraminate synthetase , cytidine 5'-monophosphate N-acetylneuraminate synthetase , N-acetylneuraminate-9-phosphate phosphatase , N-acetylneuraminate-9-phosphate phosphatase , N-acetylneuraminate 9-phosphate synthase , long-chain acyl-CoA synthetase , (25R)-3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA ligase , D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-[NRPS-pcp] synthetase , D-phenylalanyl-[NRPS-pcp] synthetase , 1-(3-amino-5-hydroxyphenyl)ethan-1-one -[PKS-acp] synthase , kanosamine 6-kinase , dTDP-L-dihydrostreptose:streatidine-6-phosphate dihydrostreptosyltransferase , ATP:inosamime phosphotransferase , N6,N6,O-tridemethylpuromycin synthetase , 3'-amino-3'-deoxyAMP monophosphatase , 3'-amino-3'-deoxyATP pyrophosphohydrolase , NAD-dependent ATP dehydrogenase , glutamyl-tRNAGln amidotransferase , 31-O-demethyl-FK506 methyltransferase , epi-isozizaene synthase , C-geranial synthase , cis-1,4-polyisoprene:isopentenyl-diphosphate cis-1,4-isoprenetransferase , isochorismate synthase , carbapenam synthetase , (+)-germacrene D synthase , 4-hydroxybenzoate geranyltransferase , 4-hydroxybenzoate geranyltransferase , N2-(2-carboxyethyl)arginine synthase , farnesyl diphosphate synthase , (R)-linalool synthase , δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase , succinyl-CoA synthetase , acetone carboxylase , ribulose bisphosphate carboxylase , chlorophyllide a divinyl reductase , α-ketoisovalerate decarboxylase , adenosyl-cobalamin-5'-phosphate synthase , D-arabinonate dehydratase , L-arabonate dehydratase , UDP-N-acetylglucosamine pyrophosphorylase , phosphoacetylglucosamine mutase , dihydroxyacetone synthase , glutamine synthetase , glutamine synthetase , asparagine synthetase , fructokinase , pyruvate kinase , succinyl-CoA synthetase , geraniol synthase , linalool synthase , 2-hydroxyhepta-2,4-dienedioate hydratase , 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase , pyruvate kinase , pyruvate kinase , molybdopterin adenylyltransferase , dimethylallyl diphosphate:umbelliferone dimethylallyltransferase , phosphatidylglycerolphosphate phosphatase , pyruvate dehydrogenase , p-hydroxyphenylpyruvate oxidase , malate synthase , isocitrate lyase , 2-hydroxy-3-oxoadipate synthase , isocitrate dehydrogenase , 2-oxobutanoate:ferredoxin oxidoreductase , 2,3-dihydroxy-isovalerate dehydratase , 2,3-dihydroxy-3-methylvalerate hydro-lyase , 2-aceto-2-hydroxy-butanoate:NADP+ oxidoreductase (isomerizing) , 2,3-dihydroxy-isovalerate:NADP+ oxidoreductase (isomerizing) , pyruvate:pyruvate acetaldehydetransferase (decarboxylating) , sulfoacetaldehyde acetyltransferase , ATP-citrate lyase , enolase , benzoate-CoA ligase , adenosyl-cobyric acid synthase , D-tagatose-6-phosphate kinase , enolase , benzoate-CoA ligase , 4-carboxy-4-hydroxy-2-oxoadipate aldolase , adenylosuccinate synthetase , benzoyl-CoA reductase , 4-oxalocitramalate aldolase , hexulose-6-phosphate synthase , pyruvate kinase , 3-hydroxybenzoate-Coenzyme A ligase , indolepyruvate decarboxylase , hexulose-6-phosphate synthase , methionine adenosyltransferase , sulfate adenylyltransferase , phosphoribosylpyrophosphate amidotransferase , hydrogenobyrinate a,c-diamide synthase , nitrogenase , acetate kinase , 6-carboxyhexanoate-CoA ligase , carbamoyl-phosphate synthetase, arginine specific , 2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase , D-ribulokinase , pyruvate kinase , phosphoenolpyruvate carboxylase , dethiobiotin synthetase , 3-methylaspartase , citramalate lyase , citramalyl-CoA lyase , UDP-galactose:MGDG galactosyltransferase , shikimate kinase , 2,3-diketo-5-methylthio-1-phosphopentane enolase , cholate-CoA ligase , nitrogenase , (2R)-phospho-3-sulfolactate synthase , 2-phospho-3-sulfolactate phosphohydrolase , lactyl-CoA dehydratase , 4-oxalocitramalate aldolase , cobaltochelatase , adenosyl-cobalamin synthase , phosphoribosylamidoimidazole-succinocarboxamide synthetase , nicotineamide mononucleotide adenylyltransferase , (3S)-3-methyl-2-oxopentanoate carboxy-lyase , keto-isocaproate decarboxylase , ADP-dependent phosphofructokinase , ADP-dependent glucokinase , inosine kinase , guanosine kinase , S-adenosylmethionine synthetase , 2,3-dimethylmalate lyase , sorbitol-6-phosphate phosphatase , O-succinylbenzoate-CoA ligase , GDP-L-fucose pyrophosphorylase , L-arginine decarboxyoxidase


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