MetaCyc Compound: Ni2+

Synonyms: nickel, Ni++, Ni+2

Superclasses: an ion a cation an inorganic cation a divalent inorganic cation
an ion an inorganic ion an inorganic cation a divalent inorganic cation

Component of: nickel sulphate

Chemical Formula: Ni

Molecular Weight: 58.7 Daltons

Monoisotopic Molecular Weight: 59.9509979642 Daltons

SMILES: [Ni++]

InChI: InChI=1S/Ni/q+2


Unification Links: ChEBI:49786 , ChemSpider:909 , HMDB:HMDB02457 , IAF1260:34516 , KEGG:C19609 , PubChem:934

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -1.2482376 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

factor 430 biosynthesis :
precorrin-2 + Ni2+ + 2 ammonium → pyrrocorphinate + 2 H2O + 3 H+

In Reactions of unknown directionality:

Not in pathways:
an apo-[carbon monoxide dehydrogenase] + Ni2+ = a holo-[carbon monoxide dehydrogenase]

In Transport reactions:
Ni2+[extracellular space] + ATP + H2O ↔ Ni2+[cytosol] + ADP + phosphate + H+ ,
Ni2+[periplasmic space]Ni2+[cytosol] ,
Ni2+[periplasmic space] + ATP + H2O → Ni2+[cytosol] + ADP + phosphate + H+

Enzymes activated by Ni2+, sorted by the type of activation, are:

Activator (Allosteric) of: nicotinate nucleotide adenylyltransferase [Emanuelli99] , phosphomannose isomerase [Shinabarger91] , formaldehyde dehydrogenase , GDP-glucose trehalose-6-phosphate synthase [Elbein68]

Activator (Mechanism unknown) of: argininosuccinate lyase [Vogel74] , fructoselysine 3-epimerase [Wiame04] , cysteinylglycine dipeptidase [Suzuki01a] , 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) [Funa05] , D-fructose-6-phosphate cytidylyltransferase [Wang12a] , 4-hydroxy-2-nonenal-N-acetyl-L-cysteine deacetylase [Tsirulnikov09] , D-xylulose-5-phosphate cytidylyltransferase [Wang12b] , 3-phosphonopyruvate hydrolase [Kulakova03] , exotrigalacturonate lyase [Shevchik99] , digalacturonate lyase [Shevchik99] , dihydrocoumarin hydrolase [Kosuge62] , 2-keto-3-deoxy-D-glycero-D-galacto-nononate-9-phosphate synthase [Angata99] , mandelate racemase [WeilMalherbe66] , 4-diphosphocytidyl-2C-methyl-D-erythritol synthase [Rohdich00a] , UDP-N-acetylglucosamine pyrophosphorylase [Szumilo96]

Enzymes inhibited by Ni2+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: tyrosine 3-monooxygenase [Haavik91] , enolase [Miernyk84] , enolase [Miernyk84]

Inhibitor (Mechanism unknown) of: lipopolysaccharide glucosyltransferase [Qian14] , N-acetylglutamylphosphate reductase [Vogel74] , acetylornithine deacetylase [Vogel74a] , methylglyoxal reductase (NADPH-dependent) [Saikusa87] , α-galactosidase [Burstein71] , threonine dehydrogenase [Boylan81, Craig86] , fructose bisphosphate aldolase [Macomber11] , GTPase [Sydor13] , D-aminopropanol dehydrogenase [Kelley84, Campbell78] , glutamate-5-semialdehyde dehydrogenase [Hayzer82] , amylomaltase [Wiesmeyer60] , dipeptidyl carboxypeptidase [Henrich93] , lactose 2-epimerase [Taguchi08] , 6-hydroxy-deoxybrevianamide E prenyltransferase [Ding10] , maleylpyruvate hydrolase [Liu13a] , cellobiose 2-epimerase [Taguchi08] , 3,7,4'-trimethylquercetin 3'-O-methyltransferase [Seguin98] , 2'-hydroxy-3,7,4'-trimethylquercetin 3'-O-methyltransferase [Seguin98] , 3,6,7,4'-tetramethylquercetagetin 3'-O-methyltransferase [Seguin98] , 2'-hydroxy-3,6,7,4'-tetramethylquercetagetin 3'-O-methyltransferase [Seguin98] , 7'-O-demethylcephaeline 7'-O-methyltransferase [Cheong11] , omega-hydroxypalmitate O-feruloyl transferase [Rautengarten12] , superoxide dismutase [Takenaka11] , 2-amino-5-carboxymuconic 6-semialdehyde deaminase [Orii04] , pullulanase [Dong97] , glycerol-2-phosphate cytidylyltransfrase [Wang10c] , 1,3-dihydroxyacetone reductase [Wang10c] , N-cyclohexylformamide hydratase [Goda01] , chondroitin sulfate A endolyase [Hamai97] , UDP-D-xylose:β-D-glucoside α-1,3-D-xylosyltransferase [Ishimizu07] , phenylacetyl-coenzyme A:glycine N-acyltransferase [Nandi79] , β-alanine amide amidase [Komeda04] , 2-aminomuconate-semialdehyde dehydrogenase [Ichiyama65] , quercetin 3'-O-methyltransferase [Muzac00] , 3-carboxymuconate cycloisomerase [Ornston66] , hydrogenase [Schink79] , iminodiacetate dehydrogenase [Uetz93] , 27-O-demethyl-rifamycin SV methyltransferase [Xu03] , tetrahydroprotoberberine cis-N-methyltransferase [Liscombe07] , deacetoxycephalosporin C hydroxylase [Baker91] , pyruvate kinase [Singh98] , S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase [Sato94] , sucrose synthase [Elling95] , trehalose synthase [Nishimoto96] , 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase [Morishige00] , L-carnitine dehydrogenase [Mori88] , trehalose phosphorylase [Kizawa95] , sulfur:ferric ion oxidoreductase [Sugio89] , naringenin 7-O-methyltransferase [Rakwal00] , L-sorbosone dehydrogenase [Asakura99] , phosphohexose isomerase [Sangwan90] , L-asparaginase [Raha90] , α-D-galactosyl-(1-3)-1D-myo-inositol:raffinose galactosyltransferase [Gaudreault81]

Inhibitor (Other types) of: amidase [Nawaz94] , raffinose synthase [Peterbauer02]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: glyoxalase I , ureidoglycolate lyase , aminopeptidase , examinopeptidase , 3'-nucleotidase , 5'-nucleotidase , methylmalonyl-CoA epimerase , (+)-germacrene D synthase , phosphoenolpyruvate mutase , cellulase , carbon-monoxide dehydrogenase , 2-keto-3-deoxy-L-rhamnoate aldolase , hydrogenase , N-acetylneuraminate 9-phosphate synthase , kanosamine 6-kinase , Ech hydrogenase , factor F420-reducing hydrogenase , H2:sulfur oxidoreductase , 2,3-dihydroxy-isovalerate dehydratase , 2,3-dihydroxy-3-methylvalerate hydro-lyase , urease , hydrogenase , urease , hydrogenase , acetyl-CoA decarbonylase/synthase , methyl viologen-reducing hydrogenase , urease , acireductone dioxygenase [nickel(II)-requiring] , carbon monoxide dehydrogenase , urease

This compound has been characterized as an alternative cofactor or prosthetic group of the following enzymes: methionine adenosyltransferase , phenylhydantoinase , NMN adenylyltransferase , allantoinase

This compound has been characterized as an alternative substrate of the following enzymes: Zn2+:H+ antiporter , Zn2+-exporting ATPase


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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