Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Compound: Ni2+

Synonyms: nickel, Ni++, Ni+2

Superclasses: an ion a cation

Component of: nickel sulphate

Chemical Formula: Ni

Molecular Weight: 58.7 Daltons

Monoisotopic Molecular Weight: 59.9509979642 Daltons

SMILES: [Ni++]

InChI: InChI=1S/Ni/q+2

InChIKey: InChIKey=VEQPNABPJHWNSG-UHFFFAOYSA-N

Unification Links: ChEBI:49786 , ChemSpider:909 , HMDB:HMDB02457 , IAF1260:34516 , KEGG:C19609 , PubChem:934

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -1.2482376 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

factor 430 biosynthesis :
precorrin-2 + Ni2+ + 2 ammonium → pyrrocorphinate + 2 H2O + 3 H+

In Reactions of unknown directionality:

Not in pathways:
an apo carbon monoxide dehydrogenase + Ni2+ = a holo carbon monoxide dehydrogenase

In Transport reactions:
Ni2+[extracellular space] + ATP + H2O ↔ Ni2+[cytosol] + ADP + phosphate + H+ ,
Ni2+[periplasmic space]Ni2+[cytosol] ,
Ni2+[periplasmic space] + ATP + H2O → Ni2+[cytosol] + ADP + phosphate + H+

Enzymes activated by Ni2+, sorted by the type of activation, are:

Activator (Allosteric) of: nicotinate nucleotide adenylyltransferase [Emanuelli99] , phosphomannose isomerase [Shinabarger91] , formaldehyde dehydrogenase , GDP-glucose trehalose-6-phosphate synthase [Elbein68]

Activator (Mechanism unknown) of: fructoselysine 3-epimerase [Wiame04] , argininosuccinate lyase [Vogel74] , cysteinylglycine dipeptidase [Suzuki01a] , 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) [Funa05] , D-fructose-6-phosphate cytidylyltransferase [Wang12b] , 4-hydroxy-2-nonenal-N-acetyl-L-cysteine deacetylase [Tsirulnikov09] , D-xylulose-5-phosphate cytidylyltransferase [Wang12] , 3-phosphonopyruvate hydrolase [Kulakova03] , exotrigalacturonate lyase [Shevchik99] , digalacturonate lyase [Shevchik99] , dihydrocoumarin hydrolase [Kosuge62] , 2-keto-3-deoxy-D-glycero-D-galacto-nononate-9-phosphate synthase [Angata99] , mandelate racemase [WeilMalherbe66] , 4-diphosphocytidyl-2C-methyl-D-erythritol synthase [Rohdich00] , UDP-N-acetylglucosamine pyrophosphorylase [Szumilo96]

Enzymes inhibited by Ni2+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: tyrosine 3-monooxygenase [Haavik91] , enolase [Miernyk84] , enolase [Miernyk84]

Inhibitor (Mechanism unknown) of: α-galactosidase [Burstein71] , N-acetylglutamylphosphate reductase [Vogel74] , acetylornithine deacetylase [Vogel74b] , threonine dehydrogenase [Boylan81, Craig86] , methylglyoxal reductase (NADPH-dependent) [Saikusa87] , D-aminopropanol dehydrogenase [Kelley84, Campbell78] , glutamate-5-semialdehyde dehydrogenase [Hayzer82] , dipeptidyl carboxypeptidase [Henrich93] , GTPase [Sydor13] , amylomaltase [Wiesmeyer60] , maleylpyruvate hydrolase [Liu13] , cellobiose 2-epimerase [Taguchi08] , 3,7,4'-trimethylquercetin 3'-O-methyltransferase [Seguin98] , 2'-hydroxy-3,7,4'-trimethylquercetin 3'-O-methyltransferase [Seguin98] , 3,6,7,4'-tetramethylquercetagetin 3'-O-methyltransferase [Seguin98] , 2'-hydroxy-3,6,7,4'-tetramethylquercetagetin 3'-O-methyltransferase [Seguin98] , 7'-O-demethylcephaeline 7'-O-methyltransferase [Cheong11] , omega-hydroxypalmitate O-feruloyl transferase [Rautengarten12] , superoxide dismutase [Takenaka11] , 2-amino-5-carboxymuconic 6-semialdehyde deaminase [Orii04] , pullulanase [Dong97] , glycerol-2-phosphate cytidylyltransfrase [Wang10] , 1,3-dihydroxyacetone reductase [Wang10] , N-cyclohexylformamide hydratase [Goda01] , chondroitin sulfate A endolyase [Hamai97] , UDP-D-xylose:β-D-glucoside α-1,3-D-xylosyltransferase [Ishimizu07] , phenylacetyl-coenzyme A:glycine N-acyltransferase [Nandi79] , β-alanine amide amidase [Komeda04] , 2-aminomuconate-semialdehyde dehydrogenase [Ichiyama65] , quercetin 3'-O-methyltransferase [Muzac00] , 3-carboxymuconate cycloisomerase [Ornston66b] , hydrogenase [Schink79] , iminodiacetate dehydrogenase [Uetz93] , 27-O-demethyl-rifamycin SV methyltransferase [Xu03] , tetrahydroprotoberberine cis-N-methyltransferase [Liscombe07] , deacetoxycephalosporin C hydroxylase [Baker91] , pyruvate kinase [Singh98] , S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase [Sato94] , sucrose synthase [Elling95] , trehalose synthase [Nishimoto96] , 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase [Morishige00] , L-carnitine dehydrogenase [Mori88] , trehalose phosphorylase [Kizawa95] , sulfur:ferric ion oxidoreductase [Sugio89] , naringenin 7-O-methyltransferase [Rakwal00] , L-sorbosone dehydrogenase [Asakura99] , phosphohexose isomerase [Sangwan90] , L-asparaginase [Raha90] , α-D-galactosyl-(1-3)-1D-myo-inositol:raffinose galactosyltransferase [Gaudreault81]

Inhibitor (Other types) of: amidase [Nawaz94] , raffinose synthase [Peterbauer02]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: ureidoglycolate lyase , glyoxalase I , aminopeptidase , examinopeptidase , hydrogenase , hydrogenase , 3'-nucleotidase , 5'-nucleotidase , methylmalonyl-CoA epimerase , (+)-germacrene D synthase , phosphoenolpyruvate mutase , cellulase , carbon-monoxide dehydrogenase , 2-keto-3-deoxy-L-rhamnoate aldolase , hydrogenase , N-acetylneuraminate 9-phosphate synthase , kanosamine 6-kinase , Ech hydrogenase , factor F420-reducing hydrogenase , H2:sulfur oxidoreductase , 2,3-dihydroxy-isovalerate dehydratase , 2,3-dihydroxy-3-methylvalerate hydro-lyase , urease , hydrogenase , urease , hydrogenase , acetyl-CoA decarbonylase/synthase , methyl viologen-reducing hydrogenase , urease , acireductone dioxygenase [nickel(II)-requiring] , carbon monoxide dehydrogenase , urease


References

Angata99: Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA (1999). "Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis." J Biol Chem 274(33);22949-56. PMID: 10438460

Asakura99: Asakura A, Hoshino T (1999). "Isolation and Characterization of a New Quinoprotein Dehydrogenase, L-Sorbose/L-Sorbosone Dehydrogenase." Biosci. Biotechnol. Biochem., 63 (1), 46-53.

Baker91: Baker BJ, Dotzlaf JE, Yeh WK (1991). "Deacetoxycephalosporin C hydroxylase of Streptomyces clavuligerus. Purification, characterization, bifunctionality, and evolutionary implication." J Biol Chem 266(8);5087-93. PMID: 2002049

Boylan81: Boylan SA, Dekker EE (1981). "L-threonine dehydrogenase. Purification and properties of the homogeneous enzyme from Escherichia coli K-12." J Biol Chem 1981;256(4);1809-15. PMID: 6780553

Burstein71: Burstein C, Kepes A (1971). "The alpha-galactosidase from Escherichia coli K12." Biochim Biophys Acta 1971;230(1);52-63. PMID: 5543331

Campbell78: Campbell RL, Swain RR, Dekker EE (1978). "Purification, separation, and characterization of two molecular forms of D-1-amino-2-propanol:NAD+ oxidoreductase activity from extracts of Escherichia coli K-12." J Biol Chem 253(20);7282-8. PMID: 359547

Cheong11: Cheong BE, Takemura T, Yoshimatsu K, Sato F (2011). "Molecular cloning of an O-methyltransferase from adventitious roots of Carapichea ipecacuanha." Biosci Biotechnol Biochem 75(1);107-13. PMID: 21228475

Craig86: Craig PA, Dekker EE (1986). "L-threonine dehydrogenase from Escherichia coli K-12: thiol-dependent activation by Mn2+." Biochemistry 1986;25(8);1870-6. PMID: 3518793

Dong97: Dong G, Vieille C, Zeikus JG (1997). "Cloning, sequencing, and expression of the gene encoding amylopullulanase from Pyrococcus furiosus and biochemical characterization of the recombinant enzyme." Appl Environ Microbiol 63(9);3577-84. PMID: 9293009

Elbein68: Elbein AD (1968). "Trehalose phosphate synthesis in Streptomyces hygroscopicus: purification of guanosine diphosphate D-glucose: D-glucose-6-phosphate 1-glucosyl-transferase." J Bacteriol 96(5);1623-31. PMID: 5726304

Elling95: Elling L (1995). "Effect of metal ions on sucrose synthase from rice grains--a study on enzyme inhibition and enzyme topography." Glycobiology 1995;5(2);201-6. PMID: 7780195

Emanuelli99: Emanuelli M, Carnevali F, Lorenzi M, Raffaelli N, Amici A, Ruggieri S, Magni G (1999). "Identification and characterization of YLR328W, the Saccharomyces cerevisiae structural gene encoding NMN adenylyltransferase. Expression and characterization of the recombinant enzyme." FEBS Lett 455(1-2);13-7. PMID: 10428462

Funa05: Funa N, Funabashi M, Yoshimura E, Horinouchi S (2005). "A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides." J Biol Chem 280(15);14514-23. PMID: 15701630

Gaudreault81: Gaudreault, P.R., Webb, J.A. (1981). "Stachyose synthesis in leaves of Cucurbita pepo." Phytochemistry 20:2629-2633.

Goda01: Goda M, Hashimoto Y, Shimizu S, Kobayashi M (2001). "Discovery of a novel enzyme, isonitrile hydratase, involved in nitrogen-carbon triple bond cleavage." J Biol Chem 276(26);23480-5. PMID: 11306561

Haavik91: Haavik J, Le Bourdelles B, Martinez A, Flatmark T, Mallet J (1991). "Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions." Eur J Biochem 199(2);371-8. PMID: 1676967

Hamai97: Hamai A, Hashimoto N, Mochizuki H, Kato F, Makiguchi Y, Horie K, Suzuki S (1997). "Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides." J Biol Chem 272(14);9123-30. PMID: 9083041

Hayzer82: Hayzer DJ, Leisinger T (1982). "Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase." Eur J Biochem 1982;121(3);561-5. PMID: 7035170

Henrich93: Henrich B, Becker S, Schroeder U, Plapp R (1993). "dcp gene of Escherichia coli: cloning, sequencing, transcript mapping, and characterization of the gene product." J Bacteriol 175(22);7290-300. PMID: 8226676

Ichiyama65: Ichiyama, A, Nakamura, S, Kawai, H, Honjo, T, Nishizuka, Y, Hayaishi, O, Senoh, S (1965). "Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. Enzymic formation of alpha-aminomuconic acid from 3-hydroxyanthranilic acid." J Biol Chem 240;740-9. PMID: 14275130

Ishimizu07: Ishimizu T, Sano K, Uchida T, Teshima H, Omichi K, Hojo H, Nakahara Y, Hase S (2007). "Purification and substrate specificity of UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase involved in the biosynthesis of the Xyl alpha1-3Xyl alpha1-3Glc beta1-O-Ser on epidermal growth factor-like domains." J Biochem 141(4);593-600. PMID: 17317689

Kelley84: Kelley JJ, Dekker EE (1984). "D-1-amino-2-propanol:NAD+ oxidoreductase. Purification and general properties of the large molecular form of the enzyme from Escherichia coli K12." J Biol Chem 1984;259(4);2124-9. PMID: 6365902

Kizawa95: Kizawa, H., Miyagawa, K., Sugiyama, Y. (1995). "Purification and characterization of trehalose phosphorylase from Micrococcus varians." Biosci. Biotech. Biochem. 59(10):1908-1912.

Komeda04: Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y (2004). "A novel R-stereoselective amidase from Pseudomonas sp. MCI3434 acting on piperazine-2-tert-butylcarboxamide." Eur J Biochem 271(8);1580-90. PMID: 15066183

Kosuge62: Kosuge T, Conn EE (1962). "The metabolism of aromatic compounds in higher plants. V. Purification and properties of dihydrocoumarin hydrolase of Melilotus alba." J Biol Chem 237;1653-6. PMID: 14458747

Kulakova03: Kulakova AN, Wisdom GB, Kulakov LA, Quinn JP (2003). "The purification and characterization of phosphonopyruvate hydrolase, a novel carbon-phosphorus bond cleavage enzyme from Variovorax sp Pal2." J Biol Chem 278(26);23426-31. PMID: 12697754

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Liscombe07: Liscombe DK, Facchini PJ (2007). "Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy." J Biol Chem 282(20);14741-51. PMID: 17389594

Liu13: Liu K, Liu TT, Zhou NY (2013). "HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867." Appl Environ Microbiol 79(3);1044-7. PMID: 23204427

Miernyk84: Miernyk JA, Dennis DT (1984). "Enolase isozymes from Ricinus communis: partial purification and characterization of the isozymes." Arch Biochem Biophys 233(2);643-51. PMID: 6486806

Mori88: Mori, N., Kasugai, T., Kitamato, Y., Ichikawa, Y. (1988). "Purification and some properties of carnitine dehydrogenase from Xanthomonas translucens." Agric. Biol. Chem. 52, 249-250.

Morishige00: Morishige T, Tsujita T, Yamada Y, Sato F (2000). "Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica." J Biol Chem 275(30);23398-405. PMID: 10811648

Muzac00: Muzac I, Wang J, Anzellotti D, Zhang H, Ibrahim RK (2000). "Functional expression of an Arabidopsis cDNA clone encoding a flavonol 3'-O-methyltransferase and characterization of the gene product." Arch Biochem Biophys 2000;375(2);385-8. PMID: 10700397

Nandi79: Nandi DL, Lucas SV, Webster LT (1979). "Benzoyl-coenzyme A:glycine N-acyltransferase and phenylacetyl-coenzyme A:glycine N-acyltransferase from bovine liver mitochondria. Purification and characterization." J Biol Chem 254(15);7230-7. PMID: 457678

Nawaz94: Nawaz MS, Khan AA, Seng JE, Leakey JE, Siitonen PH, Cerniglia CE (1994). "Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp." Appl Environ Microbiol 60(9);3343-8. PMID: 7944367

Nishimoto96: Nishimoto T, Nakano M, Nakada T, Chaen H, Fukuda S, Sugimoto T, Kurimoto M, Tsujisaka Y (1996). "Purification and properties of a novel enzyme, trehalose synthase, from Pimelobacter sp. R48." Biosci Biotechnol Biochem 60(4);640-4. PMID: 8829531

Orii04: Orii C, Takenaka S, Murakami S, Aoki K (2004). "A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid in Bordetella sp. strain 10d." Eur J Biochem 271(15);3248-54. PMID: 15265044

Ornston66b: Ornston LN (1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. II. Enzymes of the protocatechuate pathway." J Biol Chem 241(16);3787-94. PMID: 5916392

Peterbauer02: Peterbauer T, Mach L, Mucha J, Richter A (2002). "Functional expression of a cDNA encoding pea (Pisum sativum L.) raffinose synthase, partial purification of the enzyme from maturing seeds, and steady-state kinetic analysis of raffinose synthesis." Planta 215(5);839-46. PMID: 12244450

Raha90: Raha SK, Roy SK, Dey SK, Chakrabarty SL (1990). "Purification and properties of an L-asparaginase from Cylindrocarpon obtusisporum MB-10." Biochem Int 21(6);987-1000. PMID: 2080924

Rakwal00: Rakwal R, Agrawal GK, Yonekura M, Kodama O (2000). "Naringenin 7-O-methyltransferase involved in the biosynthesis of the flavanone phytoalexin sakuranetin from rice (Oryza sativa L.)." Plant Science 155(2);213-221. PMID: 10814825

Rautengarten12: Rautengarten C, Ebert B, Ouellet M, Nafisi M, Baidoo EE, Benke P, Stranne M, Mukhopadhyay A, Keasling JD, Sakuragi Y, Scheller HV (2012). "Arabidopsis Deficient in Cutin Ferulate encodes a transferase required for feruloylation of ω-hydroxy fatty acids in cutin polyester." Plant Physiol 158(2);654-65. PMID: 22158675

Rohdich00: Rohdich F, Wungsintaweekul J, Eisenreich W, Richter G, Schuhr CA, Hecht S, Zenk MH, Bacher A (2000). "Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana." Proc Natl Acad Sci U S A 97(12);6451-6. PMID: 10841550

Saikusa87: Saikusa T, Rhee H, Watanabe K, Murata K, Kimura A (1987). "Metabolism of 2-oxoaldehydes in bacteria: purification and characterization of methylglyoxal reductase from E. coli." Agricultural and Biological Chemistry 51(7): 1893-1899.

Sangwan90: Sangwan RS, Singh R (1990). "Characterization of amyloplastic phosphohexose isomerase from immature wheat (Triticum aestivum L.) endosperm." Indian J Biochem Biophys 27(1);23-7. PMID: 2341161

Sato94: Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y (1994). "Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells." Eur J Biochem 225(1);125-31. PMID: 7925429

Schink79: Schink B, Schlegel HG (1979). "The membrane-bound hydrogenase of Alcaligenes eutrophus. I. Solubilization, purification, and biochemical properties." Biochim Biophys Acta 1979;567(2);315-24. PMID: 36155

Seguin98: Seguin J, Muzac I, Ibrahim RK (1998). "Purification and immunological characterization of a recombinant trimethylflavonol 3'-O-methyltransferase." Phytochemistry 49(2);319-25. PMID: 9747535

Shevchik99: Shevchik VE, Condemine G, Robert-Baudouy J, Hugouvieux-Cotte-Pattat N (1999). "The exopolygalacturonate lyase PelW and the oligogalacturonate lyase Ogl, two cytoplasmic enzymes of pectin catabolism in Erwinia chrysanthemi 3937." J Bacteriol 181(13);3912-9. PMID: 10383957

Shinabarger91: Shinabarger D, Berry A, May TB, Rothmel R, Fialho A, Chakrabarty AM (1991). "Purification and characterization of phosphomannose isomerase-guanosine diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosa." J Biol Chem 266(4);2080-8. PMID: 1846611

Singh98: Singh DK, Malhotra SP, Singh R (1998). "Purification and characterizaton of plastidic pyruvate kinase from developing seeds of Brassica campestris L." Indian J Biochem Biophys 35(6);346-52. PMID: 10412228

Sugio89: Sugio T, Katagiri T, Inagaki K, Tano T (1989). "Actual substrate for elemental sulfur oxidation by sulfur:ferric ion oxidoreductase purified from Thiobacillus ferrooxidans." Biochimica et Biophysica Acta 973:250-256.

Suzuki01a: Suzuki H, Kamatani S, Kumagai H (2001). "Purification and characterization of aminopeptidase B from Escherichia coli K-12." Biosci Biotechnol Biochem 65(7);1549-58. PMID: 11515538

Sydor13: Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB (2013). "Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases." Biochemistry 52(10);1788-1801. PMID: 24449932

Szumilo96: Szumilo T, Zeng Y, Pastuszak I, Drake R, Szumilo H, Elbein AD (1996). "Purification to homogeneity and properties of UDP-GlcNAc (GalNAc) pyrophosphorylase." J Biol Chem 271(22);13147-54. PMID: 8662687

Taguchi08: Taguchi H, Hamada S, Kawauchi S, Ito H, Senoura T, Watanabe J, Nishimukai M, Ito S, Matsui H (2008). "Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme." Appl Microbiol Biotechnol 79(3);433-41. PMID: 18392616

Takenaka11: Takenaka S, Koshiya J, Okugawa S, Takata A, Murakami S, Aoki K (2011). "Fe-superoxide dismutase and 2-hydroxy-1,4-benzoquinone reductase preclude the auto-oxidation step in 4-aminophenol metabolism by Burkholderia sp. strain AK-5." Biodegradation 22(1);1-11. PMID: 20480210

Tsirulnikov09: Tsirulnikov K, Abuladze N, Newman D, Ryazantsev S, Wolak T, Magilnick N, Koag MC, Kurtz I, Pushkin A (2009). "Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel." Biochim Biophys Acta 1794(7);1049-57. PMID: 19362172

Uetz93: Uetz T, Egli T (1993). "Characterization of an inducible, membrane-bound iminodiacetate dehydrogenase from Chelatobacter heintzii ATCC 29600." Biodegradation 3: 423-434.

Vogel74: Vogel HJ, Vogel RH (1974). "Enzymes of arginine biosynthesis and their repressive control." Adv Enzymol Relat Areas Mol Biol 1974;40(0);65-90. PMID: 4365537

Vogel74b: Vogel, HJ, Vogel, RH "Enzymes of Arginine Biosynthesis." Advances in Enzymology 40:71-72 (1974).

Wang10: Wang Q, Xu Y, Perepelov AV, Xiong W, Wei D, Shashkov AS, Knirel YA, Feng L, Wang L (2010). "Characterization of the CDP-2-glycerol biosynthetic pathway in Streptococcus pneumoniae." J Bacteriol 192(20);5506-14. PMID: 20729354

Wang12: Wang Q, Xu Y, Perepelov AV, Knirel YA, Reeves PR, Shashkov AS, Guo X, Ding P, Feng L (2012). "Biochemical characterization of the CDP-D-arabinitol biosynthetic pathway in Streptococcus pneumoniae 17F." J Bacteriol 194:1868-1874. PMID: 22328666

Wang12b: Wang Q, Xu Y, Perepelov AV, Knirel YA, Reeves PR, Shashkov AS, Ding P, Guo X, Feng L (2012). "Characterization of the CDP-D-mannitol biosynthetic pathway in Streptococcus pneumoniae 35A." Glycobiology. PMID: 22833313

WeilMalherbe66: Weil-Malherbe H (1966). "Some properties of mandelate racemase from Pseudomonas fluorescens." Biochem J 101(1);169-75. PMID: 4291355

Wiame04: Wiame E, Van Schaftingen E (2004). "Fructoselysine 3-epimerase, an enzyme involved in the metabolism of the unusual Amadori compound psicoselysine in Escherichia coli." Biochem J 378(Pt 3);1047-52. PMID: 14641112

Wiesmeyer60: Wiesmeyer H, Cohn M (1960). "The characterization of the pathway of maltose utilization by Escherichia coli: II. General properties and mechanism of action of amylomaltase." Biochim Biophys Acta 39:427-439.

Xu03: Xu J, Mahmud T, Floss HG (2003). "Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699." Arch Biochem Biophys 411(2);277-88. PMID: 12623077


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC13B.