Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Compound: phosphate

Synonyms: inorganic phosphate, phosphate-inorganic, Pi, orthophosphate, PO43-, HPO42-, HPO4-2

Superclasses: an ion an anion an inorganic phosphorus-containing ion an inorganic phosphate

Component of:
diammonium phosphate
dipotassium phosphate
disodium phosphate
monoammonium dihydrogen phosphate
monosodium phosphate
monopotassium phosphate
acidulated phosphate fluoride (summary available)
disodium phosphate heptahydrate

Chemical Formula: HO4P

Molecular Weight: 95.979 Daltons

Monoisotopic Molecular Weight: 97.9768950947 Daltons

SMILES: [O-]P(=O)(O)[O-]

InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2

InChIKey: InChIKey=NBIIXXVUZAFLBC-UHFFFAOYSA-L

Unification Links: CAS:14265-44-2 , ChEBI:43474 , HMDB:HMDB00973 , IAF1260:33499 , KEGG:C00009 , KNApSAcK:C00007408 , MetaboLights:MTBLC43474 , PubChem:3681305

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -252.94714 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

adenosine nucleotides degradation IV :
AMP + phosphate → adenine + α-D-ribose 1,5-bisphosphate

allantoin degradation IV (anaerobic) :
oxamate + carbamoyl-phosphate ← oxalurate + phosphate

Bifidobacterium shunt :
D-xylulose 5-phosphate + phosphate → D-glyceraldehyde 3-phosphate + acetyl phosphate + H2O
β-D-fructofuranose 6-phosphate + phosphate → D-erythrose 4-phosphate + acetyl phosphate + H2O

C4 photosynthetic carbon assimilation cycle, NAD-ME type , C4 photosynthetic carbon assimilation cycle, NADP-ME type , C4 photosynthetic carbon assimilation cycle, PEPCK type , glutamine biosynthesis III :
pyruvate + ATP + phosphate → phosphoenolpyruvate + AMP + diphosphate + H+

CDP-diacylglycerol biosynthesis III :
an acyl-[acyl-carrier protein] + phosphate → an acyl phosphate + a holo-[acyl-carrier protein]

fluoroacetate and fluorothreonine biosynthesis :
5'-deoxy-5'-fluoroadenosine + phosphate → adenine + 5-fluoro-5-deoxy-D-ribose 1-phosphate

glycogenolysis II :
a debranched limit dextrin + n phosphate → n α-D-glucose 1-phosphate

heterolactic fermentation :
D-xylulose 5-phosphate + phosphate → D-glyceraldehyde 3-phosphate + acetyl phosphate + H2O

L-ascorbate biosynthesis I (L-galactose pathway) :
GDP-β-L-galactose + phosphate → GDP + β-L-galactose 1-phosphate + H+

L-ascorbate biosynthesis II (L-gulose pathway) :
GDP-β-L-gulose + phosphate → β-L-gulose 1-phosphate + GDP + H+

laminaribiose degradation :
laminaribiose + phosphate → β-D-glucose + α-D-glucose 1-phosphate

phenol degradation II (anaerobic) :
phenol + phosphate → phenol-phosphate + H2O

purine nucleobases degradation I (anaerobic) :
acetyl phosphate + ammonium + an oxidized thioredoxin + H2O ← glycine + a reduced thioredoxin + phosphate + H+

purine ribonucleosides degradation , urate biosynthesis/inosine 5'-phosphate degradation , xanthine and xanthosine salvage :
xanthosine + phosphate ↔ α-D-ribose-1-phosphate + xanthine

S-methyl-5'-thioadenosine degradation II :
S-methyl-5'-thioadenosine + phosphate → adenine + S-methyl-5-thio-α-D-ribose 1-phosphate

S-methyl-5'-thioadenosine degradation III :
S-methyl-5'-thioinosine + phosphate → hypoxanthine + S-methyl-5-thio-α-D-ribose 1-phosphate

salinosporamide A biosynthesis :
5'-deoxy-5'-chloroadenosine + phosphate → 5-chloro-5-deoxyribose 1-phosphate + adenine

starch biosynthesis :
[(1→4)-α-D-glucosyl]n + phosphate → [(1→4)-α-D-glucosyl](n-1) + α-D-glucose 1-phosphate

sucrose biosynthesis II :
SHG-glucosyln+1 + phosphate → SHG-glucosyln + α-D-glucose 1-phosphate

sucrose degradation IV (sucrose phosphorylase) :
sucrose + phosphate → β-D-fructofuranose + α-D-glucose 1-phosphate

sulfite oxidation II :
sulfate + ADP + H+ ← adenosine 5'-phosphosulfate + phosphate

sulfoacetaldehyde degradation I , sulfolactate degradation II :
acetyl phosphate + sulfite + H+ ← sulfoacetaldehyde + phosphate

tRNA processing :
a tRNA precursor with a short 3' extension + n phosphate → an uncharged tRNA + n a ribonucleoside diphosphate
a tRNA precursor with a 5' extension and a short 3' extension + n phosphate → a tRNA precursor with a 5' extension + a ribonucleoside diphosphate

Not in pathways:
adenylyl-[glutamine synthase] + phosphate → [a glutamine synthase] + ADP
pyruvate + phosphate + H+ + oxygen → acetyl phosphate + CO2 + hydrogen peroxide

Reactions known to produce the compound:

(4R)-carveol and (4R)-dihydrocarveol degradation , limonene degradation I (D-limonene) : (3R)-3-isopropenyl-6-oxoheptanoate + ATP + coenzyme A → (3R)-3-isopropenyl-6-oxoheptanoyl-CoA + ADP + phosphate (4S)-carveol and (4S)-dihydrocarveol degradation , limonene degradation II (L-limonene) : (3S)-3-isopropenyl-6-oxoheptanoate + ATP + coenzyme A → (3S)-3-isopropenyl-6-oxoheptanoyl-CoA + ADP + phosphate 1,3-propanediol biosynthesis (engineered) : sn-glycerol 3-phosphate + H2O → glycerol + phosphate 1,4-dihydroxy-2-naphthoate biosynthesis II (plants) : ATP + 2-succinylbenzoate + coenzyme A → 4-(2'-carboxyphenyl)-4-oxobutyryl-CoA + ADP + phosphate 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) : D-myo-inositol (1,3,4,5)-tetrakisphosphate + H2O → D-myo-inositol (1,3,4)-trisphosphate + phosphate 2'-deoxymugineic acid phytosiderophore biosynthesis , ethylene biosynthesis I (plants) , methionine degradation I (to homocysteine) , S-adenosyl-L-methionine biosynthesis , S-adenosyl-L-methionine cycle II : ATP + L-methionine + H2O → S-adenosyl-L-methionine + phosphate + diphosphate 2-aminoethylphosphonate degradation III : (2-amino-1-hydroxyethyl)phosphonate + oxygen → glycine + phosphate + 2 H+ 3,3'-dithiodipropionate degradation : 3-sulfinopropionate + ATP + coenzyme A → 3-sulfinopropanoyl-CoA + ADP + phosphate 3-amino-5-hydroxybenzoate biosynthesis : 1-deoxy-1-imino-D-erythrose 4-phosphate + phosphoenolpyruvate + H2O → 3,4-dideoxy-4-amino-D-arabino-heptulosonate 7-phosphate + phosphate 3,4-dideoxy-4-amino-D-arabino-heptulosonate 7-phosphate → 5-deoxy-5-amino-3-dehydroquinate + phosphate 3-dehydroquinate biosynthesis II (archaea) , lactate biosynthesis (archaea) : D-glyceraldehyde 3-phosphate → enolaldehyde + phosphate 3-hydroxypropanoate cycle , 3-hydroxypropanoate/4-hydroxybutanate cycle , fatty acid biosynthesis initiation I , glyoxylate assimilation , jadomycin biosynthesis , octanoyl-ACP biosynthesis (mitochondria, yeast) : ATP + acetyl-CoA + hydrogen carbonate → malonyl-CoA + ADP + phosphate + H+ 3-phosphoinositide biosynthesis : 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O → a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate 3-phosphoinositide degradation : a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O → an L-1-phosphatidyl-inositol + phosphate a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O → an L-1-phosphatidyl-inositol + phosphate a 1-phosphatidyl-1D-myo-inositol 5-phosphate + H2O → an L-1-phosphatidyl-inositol + phosphate a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O → a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O → a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O → a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O → a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O → a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O → a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate 4-ethylphenol degradation (anaerobic) : 4-hydroxyacetophenone + CO2 + ATP + 2 H2O → 4-hydroxybenzoyl-acetate + AMP + 2 phosphate + 3 H+ 5-aminoimidazole ribonucleotide biosynthesis I : ATP + N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + L-glutamine + H2O → L-glutamate + ADP + 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + phosphate + H+ ATP + 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine → ADP + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + phosphate + H+ 5-phospho-β-D-ribosylamine + ATP + glycine → ADP + N1-(5-phospho-β-D-ribosyl)glycinamide + phosphate + H+ 5-aminoimidazole ribonucleotide biosynthesis II : ATP + N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + L-glutamine + H2O → L-glutamate + ADP + 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + phosphate + H+ ATP + 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine → ADP + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + phosphate + H+ 5-phospho-β-D-ribosylamine + ATP + glycine → ADP + N1-(5-phospho-β-D-ribosyl)glycinamide + phosphate + H+ N1-(5-phospho-β-D-ribosyl)glycinamide + formate + ATP → N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + ADP + phosphate + H+ 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I , 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) : 7,8-dihydroneopterin 3'-phosphate + H2O → 7,8-dihydroneopterin + phosphate 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (archaea) : 7,8-dihydroneopterin 3'-phosphate + H2O → 7,8-dihydroneopterin + phosphate 7,8-dihydroneopterin 2'-phosphate + H2O → 7,8-dihydroneopterin + phosphate acetone degradation II (to acetoacetate) : acetone + CO2 + ATP + 2 H2O → acetoacetate + AMP + 2 phosphate + 3 H+ acetyl-CoA biosynthesis III (from citrate) : oxaloacetate + acetyl-CoA + ADP + phosphate ← citrate + ATP + coenzyme A acetylaszonalenin biosynthesis : L-tryptophan + anthranilate + 2 ATP → (R)-benzodiazepinedione + 2 ADP + 2 phosphate + H+ adenosine nucleotides degradation I : XMP + H2O → xanthosine + phosphate IMP + H2O → inosine + phosphate adenosine nucleotides degradation II : AMP[periplasmic space] + H2O[periplasmic space] → adenosine[periplasmic space] + phosphate[periplasmic space] adenosine ribonucleotides de novo biosynthesis : L-aspartate + IMP + GTP → adenylo-succinate + GDP + phosphate + 2 H+ adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I : adenosyl-cobyrinate a,c-diamide + 4 L-glutamine + 4 ATP + 4 H2O → 4 L-glutamate + adenosylcobyrate + 4 ADP + 4 phosphate + 4 H+ adenosylcobyrate + (R)-1-amino-2-propanol O-2-phosphate + ATP → adenosyl-cobinamide phosphate + ADP + phosphate + H+ adenosylcobalamin 5'-phosphate + H2O → coenzyme B12 + phosphate adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II : adenosyl-cobyrinate a,c-diamide + 4 L-glutamine + 4 ATP + 4 H2O → 4 L-glutamate + adenosylcobyrate + 4 ADP + 4 phosphate + 4 H+ adenosylcobyrate + (R)-1-amino-2-propanol O-2-phosphate + ATP → adenosyl-cobinamide phosphate + ADP + phosphate + H+ α-ribazole 5'-phosphate + H2O → α-ribazole + phosphate adenosylcobalamin salvage from cobinamide I : adenosylcobalamin 5'-phosphate + H2O → coenzyme B12 + phosphate adenosylcobalamin salvage from cobinamide II : adenosylcobyrate + (R)-1-amino-2-propanol O-2-phosphate + ATP → adenosyl-cobinamide phosphate + ADP + phosphate + H+ adenosylcobalamin 5'-phosphate + H2O → coenzyme B12 + phosphate ADP-L-glycero-β-D-manno-heptose biosynthesis : D-glycero-β-D-manno-heptose 1,7-bisphosphate + H2O → D-glycero-β-D-manno-heptose 1-phosphate + phosphate aerobactin biosynthesis : N6-acetyl-N6-hydroxy-L-lysine + citrate + 2 ATP + H2O → N1-citryl-N6-acetyl-N6-hydroxy-L-lysine + 2 ADP + 2 phosphate + 2 H+ N6-acetyl-N6-hydroxy-L-lysine + N1-citryl-N6-acetyl-N6-hydroxy-L-lysine + 2 ATP + H2O → aerobactin + 2 ADP + 2 phosphate + 2 H+ alginate degradation : alginate[extracellular space] + ATP + H2O → alginate[cytosol] + ADP + phosphate + H+ ammonia assimilation cycle I , ammonia assimilation cycle II , glutamine biosynthesis I , glutamine biosynthesis III , nitrate reduction II (assimilatory) , nitrate reduction V (assimilatory) , nitrate reduction VI (assimilatory) : ammonium + L-glutamate + ATP → L-glutamine + ADP + phosphate + H+ anhydromuropeptides recycling : UDP-N-α-D-acetylmuramate + L-alanyl-γ-D-glutamyl-meso-diaminopimelate + ATP → UDP-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate + ADP + phosphate + H+ aniline degradation : ATP + L-glutamate + aniline → ADP + N5-phenyl-L-glutamine + phosphate archaetidylinositol biosynthesis : unsaturated archaetidylinositol phosphate + H2O → unsaturated archaetidylinositol + phosphate saturated archaetidylinositol phosphate + H2O → saturated archaetidylinositol + phosphate arginine biosynthesis I (via L-ornithine) , arginine biosynthesis II (acetyl cycle) , arginine biosynthesis III (via N-acetyl-L-citrulline) , UMP biosynthesis : 2 ATP + L-glutamine + hydrogen carbonate + H2O → L-glutamate + carbamoyl-phosphate + 2 ADP + phosphate + 2 H+ arginine biosynthesis IV (archaebacteria) : 2 ATP + L-glutamine + hydrogen carbonate + H2O → L-glutamate + carbamoyl-phosphate + 2 ADP + phosphate + 2 H+ L-glutamate + a [LysW protein]-L-glutamate + ATP → an [L-2-aminoadipate carrier protein]-L-glutamate + ADP + phosphate + H+ an [L-2-aminoadipate carrier protein]-L-glutamate 5-semialdehyde + NADP+ + phosphate ← an [L-2-aminoadipate carrier protein]-L-glutamate 5-phosphate + NADPH + H+ arsenate detoxification II (glutaredoxin) : arsenite[cytosol] + ATP + H2O → arsenite[periplasmic space] + ADP + phosphate + H+ asparagine biosynthesis III (tRNA-dependent) : L-glutamine + L-aspartyl-tRNAasn + ATP + H2O → L-glutamate + L-asparaginyl-tRNAasn + ADP + phosphate + H+ bacteriochlorophyll a biosynthesis : 3-hydroxyethylchlorophyllide a + ATP + a reduced electron acceptor + H2O → 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a + ADP + an oxidized electron acceptor + phosphate 3-vinyl-bacteriochlorophyllide a + ADP + an oxidized electron acceptor + phosphate ← chlorophyllide a + ATP + a reduced electron acceptor + H2O biotin biosynthesis from 8-amino-7-oxononanoate I , biotin biosynthesis from 8-amino-7-oxononanoate II : CO2 + 7,8-diaminopelargonate + ATP → dethiobiotin + ADP + phosphate + 3 H+ biotin-carboxyl carrier protein assembly : a biotinylated [BCCP dimer] + hydrogen carbonate + ATP → a carboxylated-biotinylated [BCCP dimer] + ADP + phosphate + H+ ATP + acetyl-CoA + a carboxylated-biotinylated [BCCP dimer] + H2O → malonyl-CoA + a biotinylated [BCCP dimer] + ADP + phosphate + H+ butirosin biosynthesis : a BtrI acyl-carrier protein + L-glutamate + ATP → an L-glutamyl-[BtrI acyl-carrier protein] + ADP + phosphate a 4-amino butanoyl-[BtrI acyl-carrier protein] + L-glutamate + ATP → a 4-(γ-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + ADP + phosphate + H+ Calvin-Benson-Bassham cycle : fructose 1,6-bisphosphate + H2O → β-D-fructofuranose 6-phosphate + phosphate D-sedoheptulose-1,7-bisphosphate + H2O → D-sedoheptulose 7-phosphate + phosphate D-glyceraldehyde 3-phosphate + NADP+ + phosphate ← 1,3-bisphospho-D-glycerate + NADPH + H+ canavanine biosynthesis : L-canaline + carbamoyl-phosphate → O-ureidohomoserine + phosphate candicidin biosynthesis : 4-aminobenzoate + ATP + coenzyme A → 4-aminobenzoyl-CoA + ADP + phosphate cardiolipin biosynthesis I , cardiolipin biosynthesis II , cardiolipin biosynthesis III , phosphatidylglycerol biosynthesis I (plastidic) , phosphatidylglycerol biosynthesis II (non-plastidic) : an L-1-phosphatidylglycerol-phosphate + H2O → an L-1-phosphatidyl-glycerol + phosphate carnosine biosynthesis : β-alanine + L-histidine + ATP → carnosine + ADP + phosphate + H+ CDP-diacylglycerol biosynthesis III : sn-glycerol 3-phosphate + an acyl phosphate → a 1-acyl-sn-glycerol 3-phosphate + phosphate cephamycin C biosynthesis : deacetylcephalosporin-C + carbamoyl-phosphate → O-carbamoyl-deacetylcephalosporin C + phosphate chlorophyllide a biosynthesis I (aerobic, light-dependent) : ATP + protoporphyrin IX + Mg2+ + H2O → Mg-protoporphyrin + ADP + phosphate + 3 H+ chlorophyllide a biosynthesis II (anaerobic) : ATP + protoporphyrin IX + Mg2+ + H2O → Mg-protoporphyrin + ADP + phosphate + 3 H+ chlorophyllide a + an oxidized ferredoxin + 2 ADP + 2 phosphate ← protochlorophyllide a + a reduced ferredoxin + 2 ATP + 2 H2O chlorophyllide a biosynthesis III (aerobic, light independent) : ATP + protoporphyrin IX + Mg2+ + H2O → Mg-protoporphyrin + ADP + phosphate + 3 H+ chlorophyllide a + an oxidized ferredoxin + 2 ADP + 2 phosphate ← protochlorophyllide a + a reduced ferredoxin + 2 ATP + 2 H2O choline biosynthesis I : phosphocholine[periplasmic space] + H2O[periplasmic space] → choline[periplasmic space] + phosphate[periplasmic space] cis-genanyl-CoA degradation : cis-geranyl-CoA + hydrogen carbonate + ATP → 3-(4-methylpent-3-en-1-yl)-pent-2-enedioyl-CoA + ADP + phosphate + H+ cis-zeatin biosynthesis : cis-zeatin riboside monophosphate + H2O → cis-zeatin riboside + phosphate citrulline biosynthesis , ornithine de novo biosynthesis , proline biosynthesis I : L-glutamate-5-semialdehyde + NADP+ + phosphate ← γ-L-glutamyl 5-phosphate + NADPH + H+ clavulanate biosynthesis : D-glyceraldehyde 3-phosphate + L-arginine → L-N2-(2-carboxyethyl)arginine + phosphate + H+ CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis : α-D-mannose 6-phosphate + phosphoenolpyruvate + 5 H+ → 2-keto-3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + phosphate 2-keto-3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + H2O → 2-keto-3-deoxy-D-glycero-D-galacto-nononate + phosphate CMP-KDO biosynthesis I : 3-deoxy-D-manno-octulosonate 8-phosphate + H2O → 3-deoxy-D-manno-octulosonate + phosphate D-arabinose 5-phosphate + phosphoenolpyruvate + H2O → 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate CMP-KDO biosynthesis II (from D-arabinose 5-phosphate) : 3-deoxy-D-manno-octulosonate 8-phosphate + H2O → 3-deoxy-D-manno-octulosonate + phosphate D-arabinose 5-phosphate + phosphoenolpyruvate + H2O → 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate CMP-legionaminate biosynthesis I , CMP-legionaminate biosynthesis II : 2,4-diacetamido-2,4,6-trideoxy-α-D-mannopyranose + phosphoenolpyruvate + H2O → N, N'-diacetyllegionaminate + phosphate CMP-N-acetyl-7-O-acetylneuraminate biosynthesis : 4-O-acetyl-N-acetylmannosamine + phosphoenolpyruvate + H2O → N-acetyl-7-O-acetylneuraminate + phosphate CMP-N-acetylneuraminate biosynthesis I (eukaryotes) : N-acetyl-β-neuraminate 9-phosphate + H2O → N-acetyl-β-neuraminate + phosphate phosphoenolpyruvate + N-acetyl-D-mannosamine 6-phosphate + H2O → N-acetyl-β-neuraminate 9-phosphate + phosphate CMP-N-acetylneuraminate biosynthesis II (bacteria) : phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O → N-acetyl-β-neuraminate + phosphate

Reactions known to both consume and produce the compound:

2-aminoethylphosphonate degradation I :
phosphonoacetaldehyde + H2O ↔ acetaldehyde + phosphate + H+

3-dehydroquinate biosynthesis I :
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O ↔ 3-deoxy-D-arabino-heptulosonate-7-phosphate + phosphate
3-deoxy-D-arabino-heptulosonate-7-phosphate ↔ 3-dehydroquinate + phosphate

3-hydroxypropanoate cycle , 3-hydroxypropanoate/4-hydroxybutanate cycle , propionyl CoA degradation :
propanoyl-CoA + ATP + hydrogen carbonate ↔ (S)-methylmalonyl-CoA + ADP + phosphate + H+

acetate formation from acetyl-CoA I , acetylene degradation , gallate degradation III (anaerobic) , lysine fermentation to acetate and butyrate , methanogenesis from acetate , purine nucleobases degradation II (anaerobic) , pyruvate fermentation to acetate II , pyruvate fermentation to acetate IV , sulfoacetaldehyde degradation I , sulfolactate degradation II , superpathway of fermentation (Chlamydomonas reinhardtii) :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A

acetate formation from acetyl-CoA II , pyruvate fermentation to acetate III :
acetate + ATP + coenzyme A ↔ acetyl-CoA + ADP + phosphate

adenine and adenosine salvage I , adenine and adenosine salvage V :
adenosine + phosphate ↔ adenine + α-D-ribose-1-phosphate

adenine and adenosine salvage III :
inosine + phosphate ↔ hypoxanthine + α-D-ribose-1-phosphate
adenosine + phosphate ↔ adenine + α-D-ribose-1-phosphate

adenosine nucleotides degradation II :
inosine + phosphate ↔ hypoxanthine + α-D-ribose-1-phosphate

adenosine ribonucleotides de novo biosynthesis :
ATP + 3 H+[in] + H2O ↔ ADP + phosphate + 4 H+[out]

anaerobic energy metabolism (invertebrates, mitochondrial) :
succinate[mitochondrial lumen] + ATP[mitochondrial lumen] + coenzyme A[mitochondrial lumen] ↔ succinyl-CoA[mitochondrial lumen] + ADP[mitochondrial lumen] + phosphate[mitochondrial lumen]
propanoyl-CoA + ATP + hydrogen carbonate ↔ (S)-methylmalonyl-CoA + ADP + phosphate + H+

arginine biosynthesis I (via L-ornithine) , arginine biosynthesis IV (archaebacteria) , citrulline biosynthesis , citrulline degradation , proline biosynthesis II (from arginine) , urea cycle :
L-ornithine + carbamoyl-phosphate ↔ L-citrulline + phosphate + H+

arginine biosynthesis II (acetyl cycle) :
L-ornithine + carbamoyl-phosphate ↔ L-citrulline + phosphate + H+
N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphateN-acetylglutamyl-phosphate + NADPH + H+

arginine biosynthesis III (via N-acetyl-L-citrulline) :
N-acetyl-L-ornithine + carbamoyl-phosphate ↔ N-acetyl-L-citrulline + phosphate + H+
N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphateN-acetylglutamyl-phosphate + NADPH + H+

benzoyl-CoA degradation II (anaerobic) , benzoyl-CoA degradation III (anaerobic) :
cyclohex-1,5-diene-1-carbonyl-CoA + an oxidized ferredoxin + 2 ADP + 2 phosphate ↔ benzoyl-CoA + a reduced ferredoxin + 2 ATP + 2 H2O

Bifidobacterium shunt , formaldehyde assimilation III (dihydroxyacetone cycle) , gluconeogenesis I , gluconeogenesis III , glycerol degradation to butanol , glycolysis I (from glucose 6-phosphate) , glycolysis II (from fructose 6-phosphate) , glycolysis III (from glucose) , glycolysis VI (metazoan) , sucrose biosynthesis I (from photosynthesis) , superpathway of glucose and xylose degradation :
D-glyceraldehyde 3-phosphate + NAD+ + phosphate ↔ 1,3-bisphospho-D-glycerate + NADH + H+

C4 photosynthetic carbon assimilation cycle, NAD-ME type , C4 photosynthetic carbon assimilation cycle, NADP-ME type , C4 photosynthetic carbon assimilation cycle, PEPCK type , CO2 fixation into oxaloacetate (anapleurotic) , ethylene biosynthesis V (engineered) , gluconeogenesis II (Methanobacterium thermoautotrophicum) , glutamine biosynthesis III , Methanobacterium thermoautotrophicum biosynthetic metabolism :
oxaloacetate + phosphate ↔ phosphoenolpyruvate + hydrogen carbonate

chitin derivatives degradation :
N,N'-diacetylchitobiose + phosphateN-acetyl-α-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine

chorismate biosynthesis from 3-dehydroquinate :
shikimate 3-phosphate + phosphoenolpyruvate ↔ 5-enolpyruvyl-shikimate 3-phosphate + phosphate
5-enolpyruvyl-shikimate 3-phosphate ↔ chorismate + phosphate

ectoine biosynthesis , grixazone biosynthesis , homoserine biosynthesis , lysine biosynthesis I , lysine biosynthesis II , lysine biosynthesis III , lysine biosynthesis VI , norspermidine biosynthesis , spermidine biosynthesis II :
L-aspartate-semialdehyde + NADP+ + phosphate ↔ L-aspartyl-4-phosphate + NADPH + H+

ethylmalonyl pathway :
(S)-malate + ATP + coenzyme A ↔ (S)-malyl-CoA + ADP + phosphate

formaldehyde assimilation I (serine pathway) :
(S)-malate + ATP + coenzyme A ↔ (S)-malyl-CoA + ADP + phosphate
oxaloacetate + phosphate ↔ phosphoenolpyruvate + hydrogen carbonate

glycogen degradation I :
maltotetraose + phosphate ↔ maltotriose + α-D-glucose 1-phosphate
a glycogen + phosphate ↔ a limit dextrin + α-D-glucose 1-phosphate

glycogenolysis II :
a glycogen + phosphate ↔ a limit dextrin + α-D-glucose 1-phosphate

glycolysis IV (plant cytosol) :
β-D-fructofuranose 6-phosphate + diphosphate ↔ fructose 1,6-bisphosphate + phosphate + H+
D-glyceraldehyde 3-phosphate + NAD+ + phosphate ↔ 1,3-bisphospho-D-glycerate + NADH + H+

guanine and guanosine salvage , guanosine nucleotides degradation III :
guanosine + phosphate ↔ guanine + α-D-ribose-1-phosphate

heterolactic fermentation :
D-glyceraldehyde 3-phosphate + NAD+ + phosphate ↔ 1,3-bisphospho-D-glycerate + NADH + H+
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A

incomplete reductive TCA cycle , pyruvate fermentation to acetate V , pyruvate fermentation to acetate VI , reductive TCA cycle II , TCA cycle I (prokaryotic) , TCA cycle II (plants and fungi) , TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) :
succinate[mitochondrial lumen] + ATP[mitochondrial lumen] + coenzyme A[mitochondrial lumen] ↔ succinyl-CoA[mitochondrial lumen] + ADP[mitochondrial lumen] + phosphate[mitochondrial lumen]

kojibiose degradation :
kojibiose + phosphate ↔ D-glucopyranose + β-D-glucose 1-phosphate

L-1,2-propanediol degradation , threonine degradation I :
propanoyl-CoA + phosphate ↔ propanoyl phosphate + coenzyme A

maltose degradation :
maltose + phosphate ↔ β-D-glucose 1-phosphate + β-D-glucose

mannan degradation :
[(1→4)-β-D-mannosyl]n + phosphate ↔ [(1→4)-β-D-mannosyl]n-1 + α-D-mannose 1-phosphate
β-D-mannosyl-(1→4)-D-glucose + phosphate ↔ D-glucopyranose + α-D-mannose 1-phosphate

mannitol cycle :
β-D-fructofuranose 6-phosphate + diphosphate ↔ fructose 1,6-bisphosphate + phosphate + H+

methylaspartate cycle :
succinate[mitochondrial lumen] + ATP[mitochondrial lumen] + coenzyme A[mitochondrial lumen] ↔ succinyl-CoA[mitochondrial lumen] + ADP[mitochondrial lumen] + phosphate[mitochondrial lumen]
propanoyl-CoA + ATP + hydrogen carbonate ↔ (S)-methylmalonyl-CoA + ADP + phosphate + H+

mixed acid fermentation :
oxaloacetate + phosphate ↔ phosphoenolpyruvate + hydrogen carbonate
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A

ornithine biosynthesis :
N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphateN-acetylglutamyl-phosphate + NADPH + H+

phenol degradation II (anaerobic) :
phenol-phosphate + CO2 + H2O ↔ 4-hydroxybenzoate + phosphate + H+

purine deoxyribonucleosides degradation :
2'-deoxyinosine + phosphate ↔ hypoxanthine + 2-deoxy-α-D-ribose 1-phosphate
2'-deoxyguanosine + phosphate ↔ guanine + 2-deoxy-α-D-ribose 1-phosphate

purine deoxyribonucleosides degradation I :
2'-deoxyinosine + phosphate ↔ hypoxanthine + 2-deoxy-α-D-ribose 1-phosphate
2'-deoxyadenosine + phosphate ↔ adenine + 2-deoxy-α-D-ribose 1-phosphate
2'-deoxyguanosine + phosphate ↔ guanine + 2-deoxy-α-D-ribose 1-phosphate

purine ribonucleosides degradation :
guanosine + phosphate ↔ guanine + α-D-ribose-1-phosphate
inosine + phosphate ↔ hypoxanthine + α-D-ribose-1-phosphate
adenosine + phosphate ↔ adenine + α-D-ribose-1-phosphate

pyrimidine deoxyribonucleosides degradation :
thymidine + phosphate ↔ 2-deoxy-α-D-ribose 1-phosphate + thymine
2'-deoxyuridine + phosphate ↔ 2-deoxy-α-D-ribose 1-phosphate + uracil

pyrimidine ribonucleosides degradation :
uridine + phosphate ↔ α-D-ribose-1-phosphate + uracil

pyruvate fermentation to butanoate :
butanoyl-CoA + phosphate ↔ butanoyl phosphate + coenzyme A

reductive TCA cycle I :
succinate[mitochondrial lumen] + ATP[mitochondrial lumen] + coenzyme A[mitochondrial lumen] ↔ succinyl-CoA[mitochondrial lumen] + ADP[mitochondrial lumen] + phosphate[mitochondrial lumen]
oxaloacetate + phosphate ↔ phosphoenolpyruvate + hydrogen carbonate

starch degradation III , starch degradation V :
a maltodextrin(n) + phosphate ↔ a maltodextrin(n-1) + α-D-glucose 1-phosphate

TCA cycle III (animals) :
succinate[mitochondrial lumen] + GTP[mitochondrial lumen] + coenzyme A[mitochondrial lumen] ↔ succinyl-CoA[mitochondrial lumen] + GDP[mitochondrial lumen] + phosphate[mitochondrial lumen]
succinate[mitochondrial lumen] + ATP[mitochondrial lumen] + coenzyme A[mitochondrial lumen] ↔ succinyl-CoA[mitochondrial lumen] + ADP[mitochondrial lumen] + phosphate[mitochondrial lumen]

TCA cycle VI (obligate autotrophs) :
succinate[mitochondrial lumen] + ATP[mitochondrial lumen] + coenzyme A[mitochondrial lumen] ↔ succinyl-CoA[mitochondrial lumen] + ADP[mitochondrial lumen] + phosphate[mitochondrial lumen]
oxaloacetate + phosphate ↔ phosphoenolpyruvate + hydrogen carbonate

trehalose degradation III :
α,α-trehalose 6-phosphate + phosphate ↔ β-D-glucose 6-phosphate + β-D-glucose 1-phosphate

trehalose degradation IV :
α,α-trehalose + phosphate ↔ β-D-glucose 1-phosphate + D-glucopyranose

trehalose degradation V :
α,α-trehalose + phosphate ↔ α-D-glucose + α-D-glucose 1-phosphate

UMP biosynthesis :
L-aspartate + carbamoyl-phosphate ↔ N-carbamoyl-L-aspartate + phosphate + H+

Not in pathways:
a reduced nitrogenase-reductase + an oxidized nitrogenase + 16 ATP ↔ an oxidized nitrogenase-reductase + a reduced nitrogenase + 16 ADP + 16 phosphate
thiamin diphosphate + ADP + H+ ↔ adenosine thiamine triphosphate + phosphate
L-ornithine[chloroplast stroma] + carbamoyl-phosphate[chloroplast stroma] ↔ L-citrulline[chloroplast stroma] + phosphate[chloroplast stroma] + H+[chloroplast stroma]
thiamin diphosphate + H2O ↔ thiamin phosphate + phosphate + H+
propanoate + ATP + coenzyme A ↔ propanoyl-CoA + ADP + phosphate
sucrose 6F-phosphate + phosphate ↔ α-D-glucose 1-phosphate + β-D-fructofuranose 6-phosphate
cellobionate + phosphate ↔ α-D-glucose 1-phosphate + D-gluconate
β-D-galactosyl-(1->4)-L-rhamnose + phosphate ↔ L-rhamnopyranose + α-D-galactose 1-phosphate
α-D-glucosyl-(1->3)-L-rhamnose + phosphate ↔ L-rhamnopyranose + β-D-glucose 1-phosphate
GDP-α-D-glucose + phosphate ↔ α-D-glucose 1-phosphate + GDP + H+
(ribonucleotides)(n) + phosphate ↔ (ribonucleotides)(n-1) + a nucleoside diphosphate
a purine ribonucleoside + phosphate ↔ a purine base + α-D-ribose-1-phosphate
(1,4-α-D-glucosyl)(n) + phosphate ↔ (1,4-α-D-glucosyl)(n-1) + α-D-glucose 1-phosphate
D-glyceraldehyde 3-phosphate + NAD(P)+ + phosphate ↔ 1,3-bisphospho-D-glycerate + NAD(P)H + H+

In Reactions of unknown directionality:

phosphonoacetate degradation : phosphonoacetate + H2O = acetate + phosphate + H+ Not in pathways: α-D-mannose 1-phosphate + GDP + H+ = GDP-α-D-mannose + phosphate oxaloacetate + diphosphate = CO2 + phosphoenolpyruvate + phosphate creatine-phosphate + H2O = creatine + phosphate adenosine tetraphosphate + H2O = ATP + phosphate + 2 H+ dolichyl diphosphate + H2O = a dolichyl phosphate + phosphate + H+ ATP + ADP + H+ = 5',5'''-diadenosine tetraphosphate + phosphate D-ribose 5-phosphate + ADP + H+ = ADP-D-ribose + phosphate acetate + diphosphate = acetyl phosphate + phosphate glycerol + diphosphate = sn-glycerol 3-phosphate + phosphate + H+ L-serine + diphosphate = 3-phospho-L-serine + phosphate + H+ L-lysine + carbamoyl-phosphate = L-homocitrulline + phosphate + H+ putrescine + carbamoyl-phosphate = N-carbamoylputrescine + phosphate + H+ L-ascorbate + diphosphate = 2-phospho-L-ascorbate + phosphate + H+ 3'-phosphoadenylyl-sulfate + H2O = adenosine 5'-phosphosulfate + phosphate L-aspartate + dihydroxyacetone phosphate + oxygen = quinolinate + hydrogen peroxide + phosphate + H+ + 2 H2O N6-(Δ2-isopentenyl)-adenosine 5'-triphosphate + H2O = N6-(Δ2-isopentenyl)-adenosine 5'-diphosphate + phosphate + 2 H+ N6-(Δ2-isopentenyl)-adenosine 5'-diphosphate + H2O = N6-(Δ2-isopentenyl)-adenosine 5'-monophosphate + phosphate + H+ 3-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate ATP + [phospho-α-glucan] + H2O = AMP + O-phospho-[phospho-α-glucan] + phosphate 3-phosphonopyruvate + H2O = pyruvate + phosphate + H+ carbamoyl-phosphate + N2-succinyl-L-ornithine = N-succinyl-L-citrulline + phosphate + H+ ADP + H2O = AMP + phosphate + H+ 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate + H2O = 1D-myoinositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + phosphate + H+ 5-phospho-α-D-ribose 1-diphosphate + H2O = α-D-ribose 1,5-bisphosphate + phosphate + H+ adenosine pentaphosphate + H2O = adenosine tetraphosphate + phosphate + H+ 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + phosphate + H+ 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + phosphate + H+ 3 N-hydroxy-N-succinylcadaverine + ATP = desferrioxamine G1 + ADP + phosphate + H+ + H2O a supercoiled duplex DNA + ATP = a single stranded DNA + ADP + phosphate a maltodextrin + ATP + H2O = a 6-phosphogluco-maltodextrin + AMP + phosphate a 6-phosphogluco-maltodextrin + n ATP + n H2O = a poly-6-phosphogluco-maltodextrin + n AMP + n phosphate a 6-phosphogluco-amylopectin + n H2O = amylopectin + n phosphate D-Man-β-(1→4)-GlcA-β-(1→2)-D-Man-α-(1→3)-D-Glc-β-(1→4)-D-Glc-α-1-diphospho-ditrans,octacis-undecaprenol + phosphoenolpyruvate = 4,6-CH3(COO-)C-D-Man-β-(1→4)-GlcA-β-(1→2)-D-Man-α-(1→3)-D-Glc-β-(1→4)-D-Glc-α-1-diphospho-ditrans,octacis-undecaprenol + phosphate a diphospho-1D-myo-inositol tetrakisphosphate + H2O = D-myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate + H+ peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + a protein dithiol = peroxiredoxin-(S-hydroxycysteine) + ADP + a protein disulfide + phosphate + H+ an N5-formyl-tetrahydrofolate + L-glutamate + ATP = 5-formyl-THF-Glun+1 + ADP + phosphate succinate + ITP + coenzyme A = succinyl-CoA + IDP + phosphate poly (D-glutamate)n + L-glutamate + ATP = poly (D-glutamate)(n+1) + ADP + phosphate a [Co(II) methylamine-specific corrinoid protein] + ATP + a reduced electron acceptor = a [Co(I) methylamine-specific corrinoid protein] + ADP + an oxidized electron acceptor + phosphate a [Co(II) dimethylamine-specific corrinoid protein] + ATP + a reduced electron acceptor = a [Co(I) dimethylamine-specific corrinoid protein] + ADP + an oxidized electron acceptor + phosphate a [Co(II) trimethylamine-specific corrinoid protein] + ATP + a reduced electron acceptor = a [Co(I) trimethylamine-specific corrinoid protein] + ADP + an oxidized electron acceptor + phosphate [D-GlcA-β-(1→4)-2-O-Ac-D-GlcA-β-(1→4)-D-Glc-β-(1→4)-[3-O-CH3-CH2CH(OH)C(O)-D-Gal-β-(1→3)-D-Glc-β-(1→4)-D-Glc-β-(1→4)-D-Glc-β-(1→6)]-2-O-Ac-D-Glc-α-(1→4)]n + phosphoenolpyruvate = [D-GlcA-β-(1→4)-2-O-Ac-D-GlcA-β-(1→4)-D-Glc-β-(1→4)-[3-O-CH3-CH2CH(OH)C(O)-D-Gal-β-(1→3)-4,6-CH3(COO)C-D-Glc-β-(1→4)-D-Glc-β-(1→4)-D-Glc-β-(1→6)]-2-O-Ac-D-Glc-α-(1→4)]n + phosphate D-ornithine + L-lysine + ATP = D-ornithyl-Nε-L-lysine + ADP + phosphate α-maltose 1-phosphate + (1,4-α-D-glucosyl)(n-1) = (1,4-α-D-glucosyl)(n+1) + phosphate a double stranded DNA + ATP = a negatively supercoiled DNA + ADP + phosphate a nucleoside diphosphate + H2O = a nucleoside 5'-monophosphate + phosphate + H+ an α-D-aldose 1-phosphate + ADP + H+ = an ADP-aldose + phosphate a linear α-D-glucan + ATP + H2O = [phospho-α-glucan] + AMP + phosphate + 2 H+ a 3-hydroxymethyl ceph-3-em-4-carboxylate + carbamoyl-phosphate = a 3-carbamoyloxymethylcephem + phosphate acetyl phosphate + methylamine + an oxidized thioredoxin + H2O = sarcosine + a reduced thioredoxin + phosphate + H+ acetyl phosphate + trimethylamine + an oxidized thioredoxin + H2O = glycine betaine + a reduced thioredoxin + phosphate + H+ L-lysine + acetyl phosphate = N6-acetyl-L-lysine + phosphate + H+ a pyrophosphate-containing inositol phosphate + H2O = a myo-inositol-polyphosphate + phosphate an α-D-aldose 1-phosphate + a nucleoside diphosphate + H+ = a nucleotide diphosphate-aldose + phosphate 4-methylbenzoyl-CoA + 2 ATP + a reduced electron acceptor + 2 H2O = 4-methylcyclohex-1,5-diene-1-carbonyl-CoA + 2 ADP + an oxidized electron acceptor + 2 phosphate + 2 H+ ATP + (S)-NADPHX = ADP + NADPH + phosphate + H+ a purine ribonucleoside + diphosphate = a purine ribonucleoside 5'-monophosphate + phosphate + H+ 4-phospho-hydroxy-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate 8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 phosphate + 2 H+ dTDP + H2O = dTMP + phosphate + H+ dADP + H2O = dAMP + phosphate + H+ dGDP + H2O = dGMP + phosphate + H+ dUDP + H2O = dUMP + phosphate + H+ cob(II)yrinate c-monoamide + L-glutamine + ATP + H2O = cob(II)yrinate a,c-diamide + L-glutamate + ADP + phosphate + H+ cobyrinate + L-glutamine + ATP + H2O = cob(II)yrinate c-monoamide + L-glutamate + ADP + phosphate + H+ β-L-arabinose 1-phosphate + UDP + H+ = UDP-β-L-arabinopyranose + phosphate 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+ 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+ 1D-myoinositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+ (5R)-5-phosphonooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + ammonium + phosphate phosphoryl-ethanolamine + H2O = ammonium + acetaldehyde + phosphate D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + ammonium = pyridoxal 5'-phosphate + phosphate + H+ + 4 H2O 6 a reduced flavodoxin + N2 + n ATP + 6 H+ = 6 an oxidized flavodoxin + 2 ammonium + n ADP + n phosphate 2 α-D-glucose 1-phosphate + H2O = maltose + 2 phosphate carbamoyl-phosphate + ATP + H2O = O-carbamoyladenylate + diphosphate + phosphate nicotinamide + α-D-ribose-1-phosphate + H+ = 1-(β-D ribofuranosyl)nicotinamide + phosphate a [protein]-Nω-phospho-L-arginine + H2O = a [protein]-L-arginine + phosphate N6-L-threonylcarbamoyladenine37 in tRNA + ATP = cyclic N6-L-threonylcarbamoyladenosine 37 in tRNA + ADP + phosphate pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate (deoxynucleotides)(m) + ADP + (deoxynucleotides)(n) = (deoxynucleotides)(n+m) + AMP + phosphate 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde + 2-methyl-3-n-amyl-pyrrole + ATP = norprodigiosin + ADP + phosphate + H+ 4-methoxy-2,2'-bipyrrole-5-carbaldehyde + 2-undecylpyrrole + ATP = undecylprodigiosin + ADP + phosphate + H+ a tRNA 2-thiouridine34 + GTP + glycine + a 5,10-methylene-tetrahydrofolate + H2O = a tRNA containing 5-carboxymethylaminomethyl-2-thiouridine + GDP + a 7,8-dihydrofolate + phosphate a tRNA uridine34 + GTP + a 5,10-methylene-tetrahydrofolate + glycine + H2O = a tRNA containing 5-carboxymethylaminomethyluridine + GDP + a 7,8-dihydrofolate + phosphate (1,3-α-D-glucosyl)(n) + phosphate = (1,3-α-D-glucosyl)(n-1) + β-D-glucose 1-phosphate (1,2-β-D-glucosyl)(n) + phosphate = (1,2-β-D-glucosyl)(n-1) + α-D-glucose 1-phosphate 2-O-(α-D-glucopyranosyl)-sn-glycerol + phosphate = β-D-glucose 1-phosphate + glycerol selaginose + phosphate = α,α-trehalose + β-D-glucose 1-phosphate 4-O-β-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = N-acetyl-D-glucosamine + α-D-mannose 1-phosphate (1→6)-β-D-glucosyl-[(1→3)-β-D-glucosyl]n + phosphate = α-D-glucose 1-phosphate + (1→6)-β-D-glucosyl-[(1→3)-β-D-glucosyl]n-1 β-D-cellobiose + phosphate = α-D-glucose 1-phosphate + β-D-glucose UMP + phosphate = uracil + α-D-ribose 1,5-bisphosphate CMP + phosphate = cytosine + α-D-ribose 1,5-bisphosphate 5'-deoxyadenosine + phosphate = 5-deoxy-α-ribose 1-phosphate + adenine nigerose + phosphate = D-glucopyranose + β-D-glucose 1-phosphate maltoheptaose + phosphate = maltohexaose + α-D-glucose 1-phosphate maltohexaose + phosphate = maltopentaose + α-D-glucose 1-phosphate maltopentaose + phosphate = α-D-glucose 1-phosphate + maltotetraose a purine 2'-deoxyribonucleoside + phosphate = a purine base + 2-deoxy-α-D-ribose 1-phosphate [a pyruvate, water dikinase]-phosphate + phosphate + H+ = a pyruvate,water dikinase + diphosphate a [pyruvate,phosphate dikinase]-phosphate + phosphate + H+ = a pyruvate,phosphate dikinase + diphosphate RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate 1,3-β-D-glucan(n) + phosphate = α-D-glucose 1-phosphate + 1,3-β-D-glucan(n-1) a cellodextrin + phosphate = (1,4-β-D-glucosyl)(n-1) + α-D-glucose 1-phosphate a glycogen + phosphate = α-D-glucose 1-phosphate + maltotetraose a linear malto-oligosaccharide [(glucose)n] + phosphate = α-D-glucose 1-phosphate + a linear malto-oligosaccharide [(glucose)n-1] sarcosine + phosphate + 3 H+ = methylamine + acetyl phosphate + H2O β-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = α-D-galactose 1-phosphate + N-acetyl-β-D-glucosamine urate-3-ribonucleoside + phosphate = α-D-ribose-1-phosphate + urate

In Transport reactions:
an oligosaccharide[extracellular space] + ATP + H2O ↔ an oligosaccharide[cytosol] + ADP + phosphate ,
an oligopeptide[extracellular space] + ATP + H2O ↔ an oligopeptide[cytosol] + ADP + phosphate ,
a teichoic acid[cytosol] + ATP + H2O ↔ a teichoic acid[cell wall] + ADP + phosphate ,
a peptide[cytosol] + ATP + H2O ↔ a peptide[extracellular space] + ADP + phosphate ,
a xenobiotic[cytosol] + ATP + H2O ↔ a xenobiotic[extracellular space] + ADP + phosphate ,
a vitamin B12[extracellular space] + ATP + H2O ↔ a vitamin B12[cytosol] + ADP + phosphate ,
a β-D glucan[cytosol] + ATP + H2O ↔ a β-D glucan[extracellular space] + ADP + phosphate ,
α factor[cytosol] + ATP + H2O ↔ α factor[extracellular space] + ADP + phosphate ,
a monosaccharide[extracellular space] + ATP + H2O ↔ a monosaccharide[cytosol] + ADP + phosphate ,
a polar amino acid[extracellular space] + ATP + H2O ↔ a polar amino acid[cytosol] + ADP + phosphate ,
a non-polar amino acid[extracellular space] + ATP + H2O ↔ a non-polar amino acid[cytosol] + ADP + phosphate ,
a polyamine[extracellular space] + ATP + H2O ↔ a polyamine[cytosol] + ADP + phosphate ,
D-glyceraldehyde 3-phosphate[cytosol] + phosphate[extracellular space] → D-glyceraldehyde 3-phosphate[cytosol] + phosphate[cytosol] ,
phosphoenolpyruvate[chloroplast stroma] + phosphate[cytosol] → phosphoenolpyruvate[cytosol] + phosphate[cytosol] ,
chloride[cytosol] + ATP + H2O ↔ chloride[extracellular space] + ADP + phosphate + H+ ,
a capsular polysaccharide[in] + ATP + H2O ↔ a capsular polysaccharide[out] + ADP + phosphate ,
ATP + K+[out] + H2O + H+[in] → ADP + K+[in] + phosphate + H+[in] + H+[in] ,
chloride[extracellular space] + ATP + H2O ↔ chloride[cytosol] + ADP + phosphate + H+ ,
ATP + K+[out] + H2O ↔ ADP + K+[in] + phosphate + H+ ,
sn-glycerol 3-phosphate[extracellular space] + ATP + H2O ↔ sn-glycerol 3-phosphate[cytosol] + ADP + phosphate + H+ ,
Ni2+[extracellular space] + ATP + H2O ↔ Ni2+[cytosol] + ADP + phosphate + H+ ,
sulfate[extracellular space] + ATP + H2O ↔ sulfate[cytosol] + ADP + phosphate + H+ ,
nitrate[extracellular space] + ATP + H2O ↔ nitrate[cytosol] + ADP + phosphate + H+ ,
phosphonate[extracellular space] + ATP + H2O ↔ phosphonate[cytosol] + ADP + phosphate + H+ ,
molybdate[extracellular space] + ATP + H2O ↔ molybdate[cytosol] + ADP + phosphate + H+ ,
Cd2+[cytosol] + ATP + H2O ↔ Cd2+[extracellular space] + ADP + phosphate + H+ ,
Fe3+[extracellular space] + ATP + H2O ↔ Fe3+[cytosol] + ADP + phosphate + H+ ,
Mn2+[extracellular space] + ATP + H2O ↔ Mn2+[cytosol] + ADP + phosphate + H+ ,
taurine[extracellular space] + ATP + H2O ↔ taurine[cytosol] + ADP + phosphate + H+ ,
guanine[extracellular space] + ATP + H2O ↔ guanine[cytosol] + ADP + phosphate + H+ ,
heme b[cytosol] + ATP + H2O ↔ heme b[periplasmic space] + ADP + phosphate + H+ ,
Cd2+[cytosol] + ATP + H2O ↔ Cd2+[vacuolar lumen] + ADP + phosphate + H+ ,
Ag+[cytosol] + ATP + H2O ↔ Ag+[extracellular space] + ADP + phosphate + H+ ,
Ca2+[plastid stroma] + ATP + H2O ↔ Ca2+[cytosol] + ADP + phosphate + H+ ,
Ca2+[in] + ATP + H2O ↔ Ca2+[out] + ADP + phosphate + H+ ,
Ca2+[out] + ATP + H2O ↔ Ca2+[in] + ADP + phosphate + H+ ,
a quaternary amine[extracellular space] + ATP + H2O ↔ a quaternary amine[cytosol] + ADP + phosphate + H+ ,
a lipopolysaccharide[cytosol] + ATP + H2O → a lipopolysaccharide[periplasmic space] + ADP + phosphate + H+ ,
Zn2+[cytosol] + ATP + H2O → Zn2+[periplasmic space] + ADP + phosphate + H+ ,
a long-chain acyl-CoA[peroxisomal membrane] + ATP + H2O ↔ a long-chain acyl-CoA[peroxisomal membrane] + ADP + phosphate + H+ ,
lipid A-core[cytosol] + ATP + H2O → lipid A-core[periplasmic space] + ADP + phosphate + H+ ,
Cu2+[out] + ATP + H2O ↔ Cu2+[in] + ADP + phosphate + H+ ,
an aminoalkylphosphonate[periplasmic space] + ATP + H2O → an aminoalkylphosphonate[cytosol] + ADP + phosphate + H+ ,
Cu+[cytosol] + ATP + H2O ↔ Cu+[extracellular space] + ADP + phosphate + H+ ,
ATP + phosphate[periplasmic space] + H2O ↔ ADP + phosphate[cytosol] + phosphate[cytosol] + H+ ,
Cu2+[cytosol] + ATP + H2O → Cu2+[extracellular space] + ADP + phosphate + H+ ,
an Fe(III)-siderophore[extracellular space] + ATP + H2O → an Fe(III)-siderophore[cytosol] + ADP + phosphate + H+ ,
tungstate[periplasmic space] + ATP + H2O → tungstate[cytosol] + ADP + phosphate + H+ ,
Na+[cytosol] + ATP + H2O ↔ Na+[extracellular space] + ADP + phosphate + H+ ,
ATP + H+[cytosol] + H2O → ADP + phosphate + H+[extracellular space] ,
ATP[cytosol] + ADP[chloroplast stroma] + phosphate[chloroplast stroma] → ATP[chloroplast stroma] + ADP[cytosol] + phosphate[cytosol] ,
2 K+[extracellular space] + 3 Na+[cytosol] + ATP + H2O → 2 K+[cytosol] + 3 Na+[extracellular space] + ADP + phosphate + H+ ,
maltose[extracellular space] + ATP + H2O → maltose[cytosol] + ADP + phosphate + H+ ,
sn-glycerol 3-phosphate[periplasmic space] + phosphate[cytosol]sn-glycerol 3-phosphate[cytosol] + phosphate[periplasmic space] ,
α-D-mannose 6-phosphate[periplasmic space] + phosphate[cytosol] → α-D-mannose 6-phosphate[cytosol] + phosphate[periplasmic space] ,
phosphate[periplasmic space] + H+[periplasmic space]phosphate[cytosol] + H+[cytosol] ,
L-glyceraldehyde 3-phosphate[periplasmic space] + phosphate[cytosol] → L-glyceraldehyde 3-phosphate[cytosol] + phosphate[periplasmic space] ,
β-D-glucose 6-phosphate[periplasmic space] + phosphate[cytosol] → β-D-glucose 6-phosphate[cytosol] + phosphate[periplasmic space] ,
β-D-fructofuranose 6-phosphate[periplasmic space] + phosphate[cytosol] → β-D-fructofuranose 6-phosphate[cytosol] + phosphate[periplasmic space] ,
phosphate[cytosol]phosphate[periplasmic space] ,
maltotetraose[periplasmic space] + ATP + H2O → ADP + maltotetraose[cytosol] + phosphate + H+ ,
ATP + arsenate[cytosol] + H2O → ADP + arsenate[periplasmic space] + phosphate + H+ ,
ATP + a dipeptide[periplasmic space] + H2O → ADP + a dipeptide[cytosol] + phosphate + H+ ,
ATP + β-D-ribopyranose[periplasmic space] + H2O → ADP + β-D-ribopyranose[cytosol] + phosphate + H+ ,
ATP + a ferric hydroxamate complex[periplasmic space] + H2O → ADP + a ferric hydroxamate complex[cytosol] + phosphate ,
α-D-galactofuranose[periplasmic space] + ATP + H2O → α-D-galactofuranose[cytosol] + ADP + phosphate + H+ ,
taurine[periplasmic space] + ATP + H2O → taurine[cytosol] + ADP + phosphate + H+ ,
ATP + putrescine[periplasmic space] + H2O → ADP + putrescine[cytosol] + phosphate + H+ ,
ATP + L-methionine[periplasmic space] + H2O → ADP + L-methionine[cytosol] + phosphate + H+ ,
ATP + cob(I)alamin[periplasmic space] + H2O → ADP + cob(I)alamin[cytosol] + phosphate + H+ ,
ATP + L-ornithine[periplasmic space] + H2O → ADP + L-ornithine[cytosol] + phosphate + H+ ,
ATP + molybdate[periplasmic space] + H2O → ADP + molybdate[cytosol] + phosphate + H+ ,
a glycerophosphodiester[periplasmic space] + ATP + H2O → a glycerophosphodiester[cytosol] + ADP + phosphate + H+ ,
ATP + L-aspartate[periplasmic space] + H2O → L-aspartate[cytosol] + ADP + phosphate + H+ ,
glutathione[cytosol] + ATP + H2O → glutathione[periplasmic space] + ADP + phosphate + H+ ,
ATP + sn-glycerol 3-phosphate[periplasmic space] + H2O → ADP + sn-glycerol 3-phosphate[cytosol] + phosphate + H+ ,
ATP + L-isoleucine[periplasmic space] + H2O → ADP + L-isoleucine[cytosol] + phosphate + H+ ,
N-acetyl-DL-methionine[periplasmic space] + ATP + H2O → N-acetyl-DL-methionine[cytosol] + ADP + phosphate + H+ ,
heme b[cytosol] + ATP + H2O → heme b[periplasmic space] + ADP + phosphate + H+ ,
ATP + ferric dicitrate[periplasmic space] + H2O → ADP + ferric dicitrate[cytosol] + phosphate + H+ ,
L-lysine[periplasmic space] + ATP + H2O → L-lysine[cytosol] + ADP + phosphate + H+ ,
ATP + L-glutamine[periplasmic space] + H2O → ADP + L-glutamine[cytosol] + phosphate + H+ ,
β-D-galactofuranose[periplasmic space] + ATP + H2O → β-D-galactofuranose[cytosol] + ADP + phosphate + H+ ,
ATP + thiosulfate[periplasmic space] + H2O → ADP + thiosulfate[cytosol] + phosphate + H+ ,
ATP + L-proline[periplasmic space] + H2O → ADP + L-proline[cytosol] + phosphate + H+ ,
selenate[periplasmic space] + ATP + H2O → selenate[cytosol] + ADP + phosphate + H+ ,
ATP + an aliphatic sulfonate[periplasmic space] + H2O → an aliphatic sulfonate[cytosol] + ADP + phosphate + H+ ,
ATP + an alkylphosphonate[periplasmic space] + H2O → ADP + an alkylphosphonate[cytosol] + phosphate + H+ ,
ATP + L-alanyl-γ-D-glutamyl-meso-diaminopimelate[periplasmic space] + H2O → L-alanyl-γ-D-glutamyl-meso-diaminopimelate[cytosol] + ADP + phosphate + H+ ,
ATP + L-arginine[periplasmic space] + H2O → ADP + L-arginine[cytosol] + phosphate + H+ ,
ATP + L-arabinose[periplasmic space] + H2O → ADP + L-arabinose[cytosol] + phosphate + H+ ,
ATP + L-leucine[periplasmic space] + H2O → ADP + L-leucine[cytosol] + phosphate + H+ ,
maltose[periplasmic space] + ATP + H2O → maltose[cytosol] + ADP + phosphate + H+ ,
L-methionine S-oxide[periplasmic space] + ATP + H2O → L-methionine S-oxide[cytosol] + ADP + phosphate + H+ ,
ATP + D-methionine[periplasmic space] + H2O → ADP + D-methionine[cytosol] + phosphate + H+ ,
a quaternary amine[periplasmic space] + ATP + H2O → a quaternary amine[cytosol] + ADP + phosphate + H+ ,
ATP + thiamin[periplasmic space] + H2O → ADP + thiamin[cytosol] + phosphate + H+ ,
ATP + L-glutamate[periplasmic space] + H2O → ADP + L-glutamate[cytosol] + phosphate + H+ ,
maltotriose[periplasmic space] + ATP + H2O → ADP + maltotriose[cytosol] + phosphate + H+ ,
Mg2+[periplasmic space] + ATP + H2O → Mg2+[cytosol] + ADP + phosphate + H+ ,
sulfate[periplasmic space] + ATP + H2O → sulfate[cytosol] + ADP + phosphate + H+ ,
ATP + phosphate[periplasmic space] + H2O → ADP + 2 phosphate[cytosol] + H+ ,
ATP + ferric enterobactin complex[periplasmic space] + H2O → ADP + ferric enterobactin complex[cytosol] + phosphate + H+ ,
selenite[periplasmic space] + ATP + H2O → selenite[cytosol] + ADP + phosphate + H+ ,
K+[periplasmic space] + ATP + H2O → K+[cytosol] + ADP + phosphate + H+ ,
Zn2+[periplasmic space] + ATP + H2O → Zn2+[cytosol] + ADP + phosphate + H+ ,
ATP + spermidine[periplasmic space] + H2O → ADP + spermidine[cytosol] + phosphate + H+ ,
(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran[periplasmic space] + ATP + H2O → (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran[cytosol] + ADP + phosphate + H+ ,
L-cysteine[cytosol] + ATP + H2O → L-cysteine[periplasmic space] + ADP + phosphate + H+ ,
D-allose[periplasmic space] + ATP + H2O → D-allose[cytosol] + ADP + phosphate + H+ ,
Ni2+[periplasmic space] + ATP + H2O → Ni2+[cytosol] + ADP + phosphate + H+ ,
ATP + L-valine[periplasmic space] + H2O → ADP + L-valine[cytosol] + phosphate + H+ ,
ATP + β-D-galactose[periplasmic space] + H2O → ADP + β-D-galactose[cytosol] + phosphate + H+ ,
methyl-β-D-galactoside[periplasmic space] + ATP + H2O → methyl-β-D-galactoside[cytosol] + ADP + phosphate + H+ ,
Cu+[cytosol] + ATP + H2O → Cu+[periplasmic space] + ADP + phosphate + H+ ,
glutathione[periplasmic space] + ATP + H2O → glutathione[cytosol] + ADP + phosphate + H+ ,
ATP + D-xylose[periplasmic space] + H2O → ADP + D-xylose[cytosol] + phosphate + H+ ,
ATP + L-histidine[periplasmic space] + H2O → ADP + L-histidine[cytosol] + phosphate + H+ ,
ATP + 4 H+[in] + H2O ↔ ADP + phosphate + 5 H+[out] ,
a phospholipid[in] + ATP + H2O → a phospholipid[out] + ADP + phosphate + H+ ,
Mg2+[extracellular space] + ATP + H2O → Mg2+[cytosol] + ADP + phosphate + H+ ,
Na+[in] + ATP + H2O ↔ Na+[out] + ADP + phosphate + H+ ,
thiamin diphosphate + phosphate + n H+[periplasmic space] → thiamin triphosphate + H2O + n H+[cytosol]

Enzymes activated by phosphate, sorted by the type of activation, are:

Activator (Allosteric) of: glutaminase [Curthoys76]

Activator (Mechanism unknown) of: ribose-phosphate diphosphokinase [HoveJensen86, Willemoes00] , cardiolipin synthase [Hiraoka91, Ragolia94] , cardiolipin synthase [Guo00] , ribokinase [Maj01] , acetylornithine deacetylase , UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase [Michaud90, Comment 1] , glutamine synthetase deadenylase [Shapiro69] , phosphoenolpyruvate carboxylase [Murmu03] , pyruvate kinase [Singh98] , starch branching enzyme [Rydberg01] , starch branching enzyme [Weisweiler75] , glutaminase [Klein02] , 6-phosphofructokinase [Turner03] , L-asparaginase [Raha90]

Enzymes inhibited by phosphate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: imidazoleglycerol-phosphate dehydratase [Brady73] , acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase [Green84] , uridine phosphorylase [Comment 2] , transaldolase [Sprenger95b] , fructose 1,6-bisphosphatase [Brown09, Donahue00] , fructose 6-phosphate aldolase [Schurmann01] , alkaline phosphatase [Kim91] , acylphosphatase [Ramazzotti06] , trehalose-6-phosphate phosphatase [Friedman71] , myo-inositol-1-phosphate monophosphatase [McAllister92] , enolase [Schurig95a] , indole-3-glycerol phosphate synthase [Merz99] , ADP-glucose trehalose-6-phosphate synthase [Paschoalin89]

Inhibitor (Uncompetitive) of: GTP cyclohydrolase [Yim76]

Inhibitor (Noncompetitive) of: 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Sheflyan99] , methionine adenosyltransferase [Markham80] , pyruvate kinase [Somani77] , 2-dehydro-3-deoxyphosphoheptonate aldolase [Schoner76] , phosphotransbutyrylase [Wiesenborn89a, Comment 3] , sulfite:cytochrome c oxidoreductase [Suzuki94a] , glutathione synthetase [Jez04]

Inhibitor (Allosteric) of: AMP nucleosidase [Comment 4] , methylglyoxal synthase [Saadat98, Hopper71, Hopper72] , ADP-glucose pyrophosphorylase [Kavakli02] , ADP-glucose pyrophosphorylase [Laughlin98] , pyruvate kinase [Abbe83]

Inhibitor (Mechanism unknown) of: phosphatidylglycerophosphatase [Funk92] , D-arabinose 5-phosphate isomerase [Lim66] , uridine phosphorylase [Comment 5] , glutaminase [Brown08] , glutaminase [Brown08] , deoxyribose 1,5-phosphomutase [HammerJespersen70] , dCTP deaminase [Johansson05] , phosphoribosylformylglycinamide cyclo-ligase [Schrimsher86, Comment 6] , UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase [PratvielSosa91] , 6-phosphofructokinase [Parducci06] , fructose-1,6-bisphosphatase [Brown09] , galactarate dehydratase [Blumenthal66] , thiosulfate sulfurtransferase [Alexander87, Cheng08] , cAMP phosphodiesterase [Amin95] , exopolyphosphatase [Akiyama93] , acid phosphatase / phosphotransferase [Thaller97] , glutamine synthetase adenylyltransferase [Ebner70a, Helmward89, Comment 7] , ADP-glucose pyrophosphorylase [Iglesias94] , phosphoenolpyruvate phosphatase [Veljanovski06] , neocarrabiose sulfate 4-sulfatase [GalperinLemaitr75] , 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate phosphatase [Walker71] , IMP 5'-nucleotidase [Spychala88] , phosphatidylinositol synthase [Antonsson94] , hypotaurine dehydrogenase [Sumizu62] , myo-inositol-hexakisphosphate 4-phosphohydrolase [Greiner02] , myo-inositol-hexakisphosphate 3-phosphohydrolase [Greiner02] , ornithine carbamoyltransferase, catabolic [Comment 8] , trehalose-6-phosphate synthase [Londesborough93] , myo-inositol-hexakisphosphate 3-phosphohydrolase [Greiner02] , mandelate racemase [WeilMalherbe66] , phosphotransacetylase [Lundie89] , choline sulfatase [Osteras98] , inosine-5'-phosphate nucleotidase [Bideon75] , 5'-AMP nucleotidase [Bideon75] , 5'-GMP-nucleotidase [Bideon75] , S-adenosylmethionine synthetase [Schroder97] , sorbitol-6-phosphate phosphatase [Zhou03] , 6-phosphofructokinase [Turner03] , alkenyl thiohydroximate-O-sulfate sulfohydrolase (epithionitrile-forming) [Burow06] , thiohydroximate-O-sulfate sulfohydrolase (nitrile-forming) [Burow06] , 3-keto-5-aminohexanoate cleavage enzyme [Yorifuji77]

Inhibitor (Other types) of: ornithine carbamoyltransferase [Kuo88] , keratan galactose-6-sulfatase [Bielicki91] , chondroitin N-acetylgalactosamine-6-sulfatase [Bielicki91] , formate--tetrahydrofolate ligase [Himes62]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: tRNA nucleotidyltransferase , trehalose-6-phosphate phosphorylase


References

Abbe83: Abbe K, Takahashi S, Yamada T (1983). "Purification and properties of pyruvate kinase from Streptococcus sanguis and activator specificity of pyruvate kinase from oral streptococci." Infect Immun 39(3);1007-14. PMID: 6840832

Akiyama93: Akiyama M, Crooke E, Kornberg A (1993). "An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon." J Biol Chem 1993;268(1);633-9. PMID: 8380170

Alexander87: Alexander K, Volini M (1987). "Properties of an Escherichia coli rhodanese." J Biol Chem 262(14);6595-604. PMID: 3553189

Amin95: Amin N, Peterkofsky A (1995). "A dual mechanism for regulating cAMP levels in Escherichia coli." J Biol Chem 270(20);11803-5. PMID: 7744829

Antonsson94: Antonsson BE (1994). "Purification and characterization of phosphatidylinositol synthase from human placenta." Biochem J 297 ( Pt 3);517-22. PMID: 8110188

Bideon75: Bideon GM (1975). "Purification and characterization of a cyclic nucleotide-regulated 5'-nucleotidase from potatoe." Biochim Biophys Acta 384(2);443-57. PMID: 235999

Bielicki91: Bielicki J, Hopwood JJ (1991). "Human liver N-acetylgalactosamine 6-sulphatase. Purification and characterization." Biochem J 279 ( Pt 2);515-20. PMID: 1953646

Blumenthal66: Blumenthal, HJ, Jepson, T "Galactarate Dehydrase." Methods in Enzymology 9:665-669 (1966).

Brady73: Brady DR, Houston LL (1973). "Some properties of the catalytic sites of imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase, a bifunctional enzyme from Salmonella typhimurium." J Biol Chem 1973;248(7);2588-92. PMID: 4349042

Brown08: Brown G, Singer A, Proudfoot M, Skarina T, Kim Y, Chang C, Dementieva I, Kuznetsova E, Gonzalez CF, Joachimiak A, Savchenko A, Yakunin AF (2008). "Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis." Biochemistry 47(21);5724-35. PMID: 18459799

Brown09: Brown G, Singer A, Lunin VV, Proudfoot M, Skarina T, Flick R, Kochinyan S, Sanishvili R, Joachimiak A, Edwards AM, Savchenko A, Yakunin AF (2009). "Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli." J Biol Chem 284(6);3784-92. PMID: 19073594

Burow06: Burow M, Markert J, Gershenzon J, Wittstock U (2006). "Comparative biochemical characterization of nitrile-forming proteins from plants and insects that alter myrosinase-catalysed hydrolysis of glucosinolates." FEBS J 273(11);2432-46. PMID: 16704417

Cheng08: Cheng H, Donahue JL, Battle SE, Ray WK, Larson TJ (2008). "Biochemical and Genetic Characterization of PspE and GlpE, Two Single-domain Sulfurtransferases of Escherichia coli." Open Microbiol J 2;18-28. PMID: 19088907

Curthoys76: Curthoys NP, Godfrey SS (1976). "Properties of rat kidney glutaminase enzymes and their role in renal ammoniagenesis." Curr Probl Clin Biochem 6;346-56. PMID: 11965

Donahue00: Donahue JL, Bownas JL, Niehaus WG, Larson TJ (2000). "Purification and characterization of glpX-encoded fructose 1, 6-bisphosphatase, a new enzyme of the glycerol 3-phosphate regulon of Escherichia coli." J Bacteriol 2000;182(19);5624-7. PMID: 10986273

Ebner70: Ebner E, Wolf D, Gancedo C, Elsasser S, Holzer H (1970). "ATP: glutamine synthetase adenylyltransferase from Escherichia coli B. Purification and properties." Eur J Biochem 1970;14(3);535-44. PMID: 4920894

Ebner70a: Ebner E, Gancedo C, Holzer H "ATP:Glutamine synthetase adenylyltransferase (Escherichia coli B)." Methods in Enzymology 1970; 17A:922-927.

Friedman71: Friedman S (1971). "Interactions among sites responsible for trehalose 6-phosphate and trehalose-activated glucose 6-phosphate hydrolysis on trehalose phosphatase isolated from Phormia regina." J Biol Chem 246(13);4122-30. PMID: 4326209

Funk92: Funk CR, Zimniak L, Dowhan W (1992). "The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase." J Bacteriol 1992;174(1);205-13. PMID: 1309518

GalperinLemaitr75: Galperin-Lemaitre H, Kirsch-Volders M, Levi S (1975). "Letter: Ultrasound and mammalian D.N.A." Lancet 2(7936);662. PMID: 52031

Green84: Green PR, Bell RM (1984). "The triose-phosphate site of homogeneous reconstituted sn-glycerol-3-phosphate acyltransferase of Escherichia coli." Biochim Biophys Acta 1984;795(2);348-55. PMID: 6383480

Greiner02: Greiner R (2002). "Purification and characterization of three phytases from germinated lupine seeds (Lupinus albus var. amiga)." J Agric Food Chem 50(23);6858-64. PMID: 12405788

Guo00: Guo D, Tropp BE (2000). "A second Escherichia coli protein with CL synthase activity." Biochim Biophys Acta 1483(2);263-74. PMID: 10634942

HammerJespersen70: Hammer-Jespersen K, Munch-Petersen A (1970). "Phosphodeoxyribomutase from Escherichia coli. Purification and some properties." Eur J Biochem 1970;17(3);397-407. PMID: 4992818

Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.

Himes62: Himes, RH, Rabinowitz, JC (1962). "Formyltetrahydrofolate synthetase. II. Characteristics of the enzyme and the enzymic reaction." J Biol Chem 237;2903-14. PMID: 13907490

Hiraoka91: Hiraoka S, Nukui K, Uetake N, Ohta A, Shibuya I (1991). "Amplification and substantial purification of cardiolipin synthase of Escherichia coli." J Biochem (Tokyo) 1991;110(3);443-9. PMID: 1663113

Hopper71: Hopper DJ, Cooper RA (1971). "The regulation of Escherichia coli methylglyoxal synthase; a new control site in glycolysis?." FEBS Lett 13(4);213-216. PMID: 11945670

Hopper72: Hopper DJ, Cooper RA (1972). "The purification and properties of Escherichia coli methylglyoxal synthase." Biochem J 1972;128(2);321-9. PMID: 4563643

HoveJensen86: Hove-Jensen B, Harlow KW, King CJ, Switzer RL (1986). "Phosphoribosylpyrophosphate synthetase of Escherichia coli. Properties of the purified enzyme and primary structure of the prs gene." J Biol Chem 1986;261(15);6765-71. PMID: 3009477

Iglesias94: Iglesias AA, Charng YY, Ball S, Preiss J (1994). "Characterization of the kinetic, regulatory, and structural properties of ADP-glucose pyrophosphorylase from Chlamydomonas reinhardtii." Plant Physiol 104(4);1287-94. PMID: 8016263

Jez04: Jez JM, Cahoon RE (2004). "Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana." J Biol Chem 279(41);42726-31. PMID: 15302873

Johansson05: Johansson E, Fano M, Bynck JH, Neuhard J, Larsen S, Sigurskjold BW, Christensen U, Willemoes M (2005). "Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes." J Biol Chem 280(4);3051-9. PMID: 15539408

Kavakli02: Kavakli IH, Kato C, Choi SB, Kim KH, Salamone PR, Ito H, Okita TW (2002). "Generation, characterization, and heterologous expression of wild-type and up-regulated forms of Arabidopsis thaliana leaf ADP-glucose pyrophosphorylase." Planta 2002;215(3);430-9. PMID: 12111225

Kim91: Kim EE, Wyckoff HW (1991). "Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis." J Mol Biol 1991;218(2);449-64. PMID: 2010919

Klein02: Klein M, Kaltwasser H, Jahns T (2002). "Isolation of a novel, phosphate-activated glutaminase from Bacillus pasteurii." FEMS Microbiol Lett 206(1);63-7. PMID: 11786258

Kuo88: Kuo LC, Miller AW, Lee S, Kozuma C (1988). "Site-directed mutagenesis of Escherichia coli ornithine transcarbamoylase: role of arginine-57 in substrate binding and catalysis." Biochemistry 1988;27(24);8823-32. PMID: 3072022

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Laughlin98: Laughlin MJ, Chantler SE, Okita TW (1998). "N- and C-terminal peptide sequences are essential for enzyme assembly, allosteric, and/or catalytic properties of ADP-glucose pyrophosphorylase." Plant J 1998;14(2);159-68. PMID: 9628013

Leung80: Leung HB, Schramm VL (1980). "Adenylate degradation in Escherichia coli. The role of AMP nucleosidase and properties of the purified enzyme." J Biol Chem 1980;255(22);10867-74. PMID: 7000783

Lim66: Lim R, Cohen SS (1966). "D-phosphoarabinoisomerase and D-ribulokinase in Escherichia coli." J Biol Chem 1966;241(19);4304-15. PMID: 5332197

Londesborough93: Londesborough J, Vuorio OE (1993). "Purification of trehalose synthase from baker's yeast. Its temperature-dependent activation by fructose 6-phosphate and inhibition by phosphate." Eur J Biochem 1993;216(3);841-8. PMID: 8404904

Lundie89: Lundie LL, Ferry JG (1989). "Activation of acetate by Methanosarcina thermophila. Purification and characterization of phosphotransacetylase." J Biol Chem 1989;264(31);18392-6. PMID: 2808380

Maj01: Maj MC, Gupta RS (2001). "The effect of inorganic phosphate on the activity of bacterial ribokinase." J Protein Chem 20(2);139-44. PMID: 11563694

Markham80: Markham GD, Hafner EW, Tabor CW, Tabor H (1980). "S-Adenosylmethionine synthetase from Escherichia coli." J Biol Chem 1980;255(19);9082-92. PMID: 6251075

McAllister92: McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI (1992). "cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme." Biochem J 284 ( Pt 3);749-54. PMID: 1377913

Merz99: Merz A, Knochel T, Jansonius JN, Kirschner K (1999). "The hyperthermostable indoleglycerol phosphate synthase from Thermotoga maritima is destabilized by mutational disruption of two solvent-exposed salt bridges." J Mol Biol 1999;288(4);753-63. PMID: 10329177

Michaud90: Michaud C, Mengin-Lecreulx D, van Heijenoort J, Blanot D (1990). "Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli." Eur J Biochem 1990;194(3);853-61. PMID: 2269304

Murmu03: Murmu J, Chinthapalli B, Raghavendra AS (2003). "Marked modulation by phosphate of phosphoenolpyruvate carboxylase in leaves of Amaranthus hypochondriacus, a NAD-ME type C4 plant: decrease in malate sensitivity but no change in the phosphorylation status." J Exp Bot 54(393);2661-8. PMID: 14585826

Osteras98: Osteras M, Boncompagni E, Vincent N, Poggi MC, Le Rudulier D (1998). "Presence of a gene encoding choline sulfatase in Sinorhizobium meliloti bet operon: choline-O-sulfate is metabolized into glycine betaine." Proc Natl Acad Sci U S A 1998;95(19);11394-9. PMID: 9736747

Parducci06: Parducci RE, Cabrera R, Baez M, Guixe V (2006). "Evidence for a catalytic Mg2+ ion and effect of phosphate on the activity of Escherichia coli phosphofructokinase-2: regulatory properties of a ribokinase family member." Biochemistry 45(30);9291-9. PMID: 16866375

Paschoalin89: Paschoalin VM, Silva JT, Panek AD (1989). "Identification of an ADPG-dependent trehalose synthase in Saccharomyces." Curr Genet 16(2);81-7. PMID: 2532070

PratvielSosa91: Pratviel-Sosa F, Mengin-Lecreulx D, van Heijenoort J (1991). "Over-production, purification and properties of the uridine diphosphate N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli." Eur J Biochem 1991;202(3);1169-76. PMID: 1765076

Ragolia94: Ragolia L, Tropp BE (1994). "The effects of phosphoglycerides on Escherichia coli cardiolipin synthase." Biochim Biophys Acta 1994;1214(3);323-32. PMID: 7918616

Raha90: Raha SK, Roy SK, Dey SK, Chakrabarty SL (1990). "Purification and properties of an L-asparaginase from Cylindrocarpon obtusisporum MB-10." Biochem Int 21(6);987-1000. PMID: 2080924

Ramazzotti06: Ramazzotti M, Parrini C, Stefani M, Manao G, Degl'innocenti D (2006). "The intrachain disulfide bridge is responsible of the unusual stability properties of novel acylphosphatase from Escherichia coli." FEBS Lett 580(30);6763-8. PMID: 17134700

Ruepp95: Ruepp A, Muller HN, Lottspeich F, Soppa J (1995). "Catabolic ornithine transcarbamylase of Halobacterium halobium (salinarium): purification, characterization, sequence determination, and evolution." J Bacteriol 1995;177(5);1129-36. PMID: 7868583

Rydberg01: Rydberg U, Andersson L, Andersson R, Aman P, Larsson H (2001). "Comparison of starch branching enzyme I and II from potato." Eur J Biochem 2001;268(23);6140-5. PMID: 11733008

Saadat98: Saadat D, Harrison DH (1998). "Identification of catalytic bases in the active site of Escherichia coli methylglyoxal synthase: cloning, expression, and functional characterization of conserved aspartic acid residues." Biochemistry 1998;37(28);10074-86. PMID: 9665712

Schoner76: Schoner R, Herrmann KM (1976). "3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase. Purification, properties, and kinetics of the tyrosine-sensitive isoenzyme from Escherichia coli." J Biol Chem 1976;251(18);5440-7. PMID: 9387

Schramm78: Schramm VL, Leung HB (1978). "Adenosine monophosphate nucleosidase from Azotobacter vinelandii and Escherichia coli." Methods Enzymol 1978;51;263-70. PMID: 357895

Schrimsher86: Schrimsher JL, Schendel FJ, Stubbe J, Smith JM (1986). "Purification and characterization of aminoimidazole ribonucleotide synthetase from Escherichia coli." Biochemistry 1986;25(15);4366-71. PMID: 3530323

Schroder97: Schroder G, Eichel J, Breinig S, Schroder J (1997). "Three differentially expressed S-adenosylmethionine synthetases from Catharanthus roseus: molecular and functional characterization." Plant Mol Biol 33(2);211-22. PMID: 9037140

Schurig95a: Schurig H, Rutkat K, Rachel R, Jaenicke R (1995). "Octameric enolase from the hyperthermophilic bacterium Thermotoga maritima: purification, characterization, and image processing." Protein Sci 1995;4(2);228-36. PMID: 7757011

Schurmann01: Schurmann M, Sprenger GA (2001). "Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases." J Biol Chem 2001;276(14);11055-61. PMID: 11120740

Shapiro69: Shapiro BM (1969). "The glutamine synthetase deadenylylating enzyme system from Escherichia coli. Resolution into two components, specific nucleotide stimulation, and cofactor requirements." Biochemistry 8(2);659-70. PMID: 4893578

Sheflyan99: Sheflyan GY, Duewel HS, Chen G, Woodard RW (1999). "Identification of essential histidine residues in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase: analysis by chemical modification with diethyl pyrocarbonate and site-directed mutagenesis." Biochemistry 1999;38(43);14320-9. PMID: 10572007

Singh98: Singh DK, Malhotra SP, Singh R (1998). "Purification and characterizaton of plastidic pyruvate kinase from developing seeds of Brassica campestris L." Indian J Biochem Biophys 35(6);346-52. PMID: 10412228

Somani77: Somani BL, Valentini G, Malcovati M (1977). "Purification and molecular properties of the AMP-activated pyruvate kinase from Escherichia coli." Biochim Biophys Acta 482(1);52-63. PMID: 193572

Sprenger95b: Sprenger GA, Schorken U, Sprenger G, Sahm H (1995). "Transaldolase B of Escherichia coli K-12: cloning of its gene, talB, and characterization of the enzyme from recombinant strains." J Bacteriol 1995;177(20);5930-6. PMID: 7592346

Spychala88: Spychala J, Madrid-Marina V, Fox IH (1988). "High Km soluble 5'-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP." J Biol Chem 263(35);18759-65. PMID: 2848805

Sumizu62: Sumizu, K. (1962). "Oxidation of hypotaurine in rat liver." Biochim Biophys Acta 63;210-2. PMID: 13979247

Suzuki94a: Suzuki, I. (1994). "Sulfite:cytochrome c oxidoreductase of Thiobacilli." Methods Enzymol. 243(32):447-454.

Thaller97: Thaller MC, Schippa S, Bonci A, Cresti S, Rossolini GM (1997). "Identification of the gene (aphA) encoding the class B acid phosphatase/phosphotransferase of Escherichia coli MG1655 and characterization of its product." FEMS Microbiol Lett 1997;146(2);191-8. PMID: 9011040

Turner03: Turner WL, Plaxton WC (2003). "Purification and characterization of pyrophosphate- and ATP-dependent phosphofructokinases from banana fruit." Planta 217(1);113-21. PMID: 12721855

Veljanovski06: Veljanovski V, Vanderbeld B, Knowles VL, Snedden WA, Plaxton WC (2006). "Biochemical and molecular characterization of AtPAP26, a vacuolar purple acid phosphatase up-regulated in phosphate-deprived Arabidopsis suspension cells and seedlings." Plant Physiol 142(3);1282-93. PMID: 16963519

Vita83: Vita A, Huang CY, Magni G (1983). "Uridine phosphorylase from Escherichia coli B.: kinetic studies on the mechanism of catalysis." Arch Biochem Biophys 1983;226(2);687-92. PMID: 6357095

Walker71: Walker MS, Walker JB (1971). "Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate." J Biol Chem 246(22);7034-40. PMID: 4331203

WeilMalherbe66: Weil-Malherbe H (1966). "Some properties of mandelate racemase from Pseudomonas fluorescens." Biochem J 101(1);169-75. PMID: 4291355

Weisweiler75: Weisweiler P, Schwandt P (1975). "Biological action of the lipotrophic peptides A and B from pig pituitary glands." Acta Endocrinol (Copenh) 1975;79(1);34-42. PMID: 1173308

Wiesenborn89a: Wiesenborn DP, Rudolph FB, Papoutsakis ET (1989). "Phosphotransbutyrylase from Clostridium acetobutylicum ATCC 824 and its role in acidogenesis." Appl Environ Microbiol 1989;55(2);317-22. PMID: 2719475

Willemoes00: Willemoes M, Hove-Jensen B, Larsen S (2000). "Steady state kinetic model for the binding of substrates and allosteric effectors to Escherichia coli phosphoribosyl-diphosphate synthase." J Biol Chem 275(45);35408-12. PMID: 10954724

Yim76: Yim JJ, Brown GM (1976). "Characteristics of guanosine triphosphate cyclohydrolase I purified from Escherichia coli." J Biol Chem 1976;251(16);5087-94. PMID: 821948

Yorifuji77: Yorifuji T, Jeng IM, Barker HA (1977). "Purification and properties of 3-keto-5-aminohexanoate cleavage enzyme from a lysine-fermenting Clostridium." J Biol Chem 252(1);20-31. PMID: 13064

Zhou03: Zhou R., Cheng L., Wayne R. (2003). "Purification and characterization of sorbitol-6-phosphate phosphatase from apple leaves." Plant Science 165:227-232.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, biocyc13.