MetaCyc Compound: dithionite

Systematic Name: tetraoxodisulfate(S-S)(2-)

Synonyms: S2O42-, hydrosulfite

Component of: sodium dithionite

Chemical Formula: O4S2

Molecular Weight: 128.12 Daltons

Monoisotopic Molecular Weight: 129.93944993259998 Daltons

dithionite compound structure

SMILES: [O-]S(=O)S(=O)[O-]

InChI: InChI=1S/H2O4S2/c1-5(2)6(3)4/h(H,1,2)(H,3,4)/p-2


Unification Links: ChEBI:42160, ChemSpider:1055, PubChem:1086

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -144.74823Inferred by computational analysis [Latendresse13]

Enzymes activated by dithionite, sorted by the type of activation, are:

Activator (Mechanism unknown) of: carbon-phosphorous lyase [Kamat11b]

Enzymes inhibited by dithionite, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: glyoxylate carboligase [Gupta66, Comment 1], 4-hydroxybenzoyl-CoA reductase [Johannes08], thiosulphate:quinone oxidoreductase [Muller04], kynurenine formamidase [Brown86], kynurenine formamidase [Brown86]


Brown86: Brown D, Hitchcock MJ, Katz E (1986). "Purification and characterization of kynurenine formamidase activities from Streptomyces parvulus." Can J Microbiol 32(6);465-72. PMID: 2425918

Gupta66: Gupta NK, Vennesland B (1966). "Glyoxylate carboligase of Escherichia coli: some properties of the enzyme." Arch Biochem Biophys 1966;113(2);255-64. PMID: 5328735

Johannes08: Johannes J, Unciuleac MC, Friedrich T, Warkentin E, Ermler U, Boll M (2008). "Inhibitors of the molybdenum cofactor containing 4-hydroxybenzoyl-CoA reductase." Biochemistry 47(17);4964-72. PMID: 18393440

Kamat11b: Kamat SS, Williams HJ, Raushel FM (2011). "Intermediates in the transformation of phosphonates to phosphate by bacteria." Nature 480(7378);570-3. PMID: 22089136

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Muller04: Muller FH, Bandeiras TM, Urich T, Teixeira M, Gomes CM, Kletzin A (2004). "Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase." Mol Microbiol 53(4);1147-60. PMID: 15306018

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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