Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Compound: dithionite

Systematic Name: tetraoxodisulfate(S-S)(2-)

Synonyms: S2O42-, hydrosulfite

Chemical Formula: O4S2

Molecular Weight: 128.12 Daltons

Monoisotopic Molecular Weight: 129.93944993259998 Daltons

SMILES: [O-]S(=O)S(=O)[O-]

InChI: InChI=1S/H2O4S2/c1-5(2)6(3)4/h(H,1,2)(H,3,4)/p-2

InChIKey: InChIKey=GRWZHXKQBITJKP-UHFFFAOYSA-L

Unification Links: ChEBI:42160 , ChemSpider:1055 , PubChem:1086

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -144.74823 Inferred by computational analysis [Latendresse13]

Enzymes activated by dithionite, sorted by the type of activation, are:

Activator (Mechanism unknown) of: carbon-phosphorous lyase [Kamat11]

Enzymes inhibited by dithionite, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: glyoxylate carboligase [Gupta66, Comment 1] , 4-hydroxybenzoyl-CoA reductase [Johannes08] , thiosulphate:quinone oxidoreductase [Muller04] , kynurenine formamidase [Brown86] , kynurenine formamidase [Brown86]


References

Brown86: Brown D, Hitchcock MJ, Katz E (1986). "Purification and characterization of kynurenine formamidase activities from Streptomyces parvulus." Can J Microbiol 32(6);465-72. PMID: 2425918

Gupta66: Gupta NK, Vennesland B (1966). "Glyoxylate carboligase of Escherichia coli: some properties of the enzyme." Arch Biochem Biophys 1966;113(2);255-64. PMID: 5328735

Johannes08: Johannes J, Unciuleac MC, Friedrich T, Warkentin E, Ermler U, Boll M (2008). "Inhibitors of the molybdenum cofactor containing 4-hydroxybenzoyl-CoA reductase." Biochemistry 47(17);4964-72. PMID: 18393440

Kamat11: Kamat SS, Williams HJ, Raushel FM (2011). "Intermediates in the transformation of phosphonates to phosphate by bacteria." Nature 480(7378);570-3. PMID: 22089136

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Muller04: Muller FH, Bandeiras TM, Urich T, Teixeira M, Gomes CM, Kletzin A (2004). "Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase." Mol Microbiol 53(4);1147-60. PMID: 15306018


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.