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MetaCyc Compound: Zn2+

Synonyms: Zn, Zinc, Zn+2, Zn++, zinc ion, Zn(II)

Superclasses: an iona cationan inorganic cationa divalent inorganic cation
an ionan inorganic ionan inorganic cationa divalent inorganic cation

Component of:
zinc hydrogenphosphate
zinc dichloride
zinc sulfate heptahydrate
zinc sulfate

Chemical Formula: Zn

Molecular Weight: 65.38 Daltons

Monoisotopic Molecular Weight: 63.9291466 Daltons

SMILES: [Zn++]

InChI: InChI=1S/Zn/q+2


Unification Links: CAS:7440-66-6, ChEBI:29105, ChemSpider:29723, HMDB:HMDB01303, IAF1260:33614, KEGG:C00038, MetaboLights:MTBLC29105, PubChem:32051

Standard Gibbs Free Energy of Formation (ΔfG in kcal/mol): -1.2482376Inferred by computational analysis [Latendresse13]

In Transport reactions:
Zn2+[cytosol] + ATP + H2O → Zn2+[periplasm] + ADP + phosphate + H+,
Zn2+[cytosol] + H+[periplasm]Zn2+[periplasm] + H+[cytosol],
Zn2+[periplasm] + ATP + H2O → Zn2+[cytosol] + ADP + phosphate + H+

Enzymes activated by Zn2+, sorted by the type of activation, are:

Activator (Allosteric) of: phosphoglycerol geranylgeranyltransferase [Chen93a], glycerol-1-phosphate dehydrogenase [Daiyasu02], (1S,4R)-1-hydroxy-2-oxolimonene monooxygenase [Van00], succinate semialdehyde reductase [Berg07], 6-pyruvoyl tetrahydrobiopterin synthase [Burgisser95], methylated MtsB protein:coenzyme M methyltransferase [Tallant01], dimethylsulfide:MtsB protein methyltransferase [Tallant01], cytosolic leucyl aminopeptidase [Taylor93], inositol-1-phosphate synthase [Chen00], [Cys-Gly]-S-conjugate dipeptidase [Taylor93], mycothiol S-conjugate amidase [Steffek03], α-acetolactate decarboxylase [Phalip94], glyoxalase I [Marmstal79], cysteinylglycine dipeptidase [Taylor93], respiratory arsenate reductase [Krafft98], glyoxalase II (cytoplasmic) [Bito99], mycothiol S-conjugate amidase [Steffek03], glyoxalase I [SaintJean98] Activator (Mechanism unknown) of: D-mannonate oxidoreductase [Portalier72b], dipeptidyl carboxypeptidase [Chen09], nonspecific dipeptidase [Schroeder94], GTPase [BlabyHaas12], Ap4A synthetase [Plateau82, Charlier87], Ap3A synthetase [Plateau82], [trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase [Sengupta14], ethanol dehydrogenase [Lessmeier13], 3-benzyl-3,6 -bis(cysteinylglycine)-6-(hydroxymethyl)-diketopiperazine dipeptidase [Scharf13], caffeoyl-CoA 3-O-methyltransferase [Ibdah03], caffeoylglucose 3-O-methyltransferase [Ibdah03], caffeate 3-O-methyltransferase [Ibdah03], quercetin 3'-O-methyltransferase [Ibdah03], gossypetin 8-methyl ester 3'-O-methyltransferase [Ibdah03], gossypetin 8-O-methyltransferase [Ibdah03], laricitrin 5'-O-methyltransferase [Ibdah03], myricetin 3'-O-methyltransferase [Ibdah03], patuletin 3'-O-methyltransferase [Ibdah03], quercetagetin 6O-methyltransferase [Ibdah03], NADH kinase [Kawai01], NAD(+) kinase [Kawai01], pyridoxal kinase [Lum02], D-xylulose-5-phosphate cytidylyltransferase [Wang12a], trehalose-6-phosphate synthase [Chaudhuri09], homophytochelatin synthase [Loscos06], homophytochelatin synthase [Oven02], GA4 carboxyl methyltransferase [Varbanova07], indole-3-acetate carboxyl methyltransferase [Zhao07a], streptomycin 6-kinase [Sugiyama83], acetylpyruvate hydrolase [Davey75], UDP-N-acetylglucosamine pyrophosphorylase [Szumilo96], caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase [Fujiwara97], caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase [Fujiwara97], molybdopterin molybdotransferase [Llamas06]

Enzymes inhibited by Zn2+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: ornithine carbamoyltransferase [Comment 1], ornithine carbamoyltransferase [Comment 2], cytosine deaminase [Porter93, Comment 3], geraniol dehydrogenase [Iijima06], tyrosine 3-monooxygenase [Haavik91], ornithine carbamoyltransferase [Comment 4], glycine formimidoyltransferase [Uyeda65] Inhibitor (Noncompetitive) of: L-alanine dehydrogenase [Yoshida70] Inhibitor (Allosteric) of: diguanylate cyclase [Zahringer13], 4-hydroxy-2-oxovalerate aldolase [Powlowski93] Inhibitor (Mechanism unknown) of: betaine aldehyde dehydrogenase [Falkenberg90], glycolaldehyde dehydrogenase [Baldoma87], taurine dioxygenase [Eichhorn97], D-galacturonate isomerase [Ashwell60], D-glucuronate isomerase [Ashwell60], fructoselysine 6-phosphate deglycase [Wiame02], fructoselysine 3-epimerase [Wiame04], glycolate oxidase [Lord72], α-galactosidase [Burstein71], deoxyribose 1,5-phosphomutase [HammerJespersen70], methylmalonyl-CoA mutase [Bobik03], N-acetylglutamate synthase [Marvil77], N-acetylglutamylphosphate reductase [Vogel74], acetylornithine deacetylase [Vogel74a, JavidMajd00], adenosylmethionine decarboxylase [Lu07], adenine phosphoribosyltransferase [Hochstadt78], hypoxanthine phosphoribosyltransferase [Hochstadt78a], inosine kinase [Mori95], guanosine kinase [Mori95], L-1,2-propanediol oxidoreductase [Obradors98, Montella05], glycolaldehyde reductase [Obradors98], glyoxalase [Subedi11], adenylosuccinate synthetase [Kang95], methylglyoxal reductase (NADPH-dependent) [Saikusa87], argininosuccinate lyase [Vogel74], phenylalanyl-tRNA synthetase [Mayaux81], glutamate decarboxylase A [Helmward89], glutamate decarboxylase B [Helmward89], tetrahydrodipicolinate succinylase [Simms84], malate dehydrogenase [Wang11c], imidazoleglycerol-phosphate dehydratase [Brady73], 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Ray80], D-arabinose 5-phosphate isomerase [Meredith05], ubiquinol oxidase (H+-transporting) [Helmward89, Kita86, Kita84], lipopolysaccharide glucosyltransferase [Qian14], UDP-3-O-acyl-N-acetylglucosamine deacetylase [Jackman99], S-formylglutathione hydrolase [Gonzalez06], S-formylglutathione hydrolase [Gonzalez06], L-serine deaminase [Newman80], selenide, water dikinase [Veres94, Kim93, Kim94], glycogen phosphorylase [Chen68, Chen68a], D-aminopropanol dehydrogenase [Kelley84, Campbell78], dipeptidyl carboxypeptidase [Henrich93], 7-α-hydroxysteroid dehydrogenase [Yoshimoto91], non-heme bacterial ferritin [Treffry98], tail-specific protease [Park88], fumarase A [Xu12], amylomaltase [Wiesmeyer60], GTPase [Sydor13], pyridine nucleotide transhydrogenase [Cao11], polyphosphate kinase [Haeusler92], 2',3'-cyclic nucleotide 2'-phosphodiesterase [ANRAKU64], 3'-nucleotidase [ANRAKU64], lysyl-tRNA synthetase [Plateau82, Charlier87], 6-aminopenicillanate acyltransferase [Alvarez87], isopenicillin N amidohydrolase [Alvarez87], isopenicillin N acyltransferase [Alvarez87], isovitexin 2''-O-arabinoside 7-O-galactosyltransferase [Van83], isovitexin 7-O-galactosyltransferase [Van83], lactose 2-epimerase [Taguchi08], 5-hydroxyanthrotainin geranyltransferase [Chooi12], coniferyl alcohol 9-O-methyltransferase [Berim07], coniferyl alcohol 9-O-methyltransferase [Berim07], N-acetylmuramoyl-L-alanine amidase [vanHeijenoort75], 6-hydroxy-deoxybrevianamide E prenyltransferase [Ding10], deoxybrevianamide F synthase [Ding10], bacillithiol-S-transferase [Thompson14a], cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase [Liu09], didemethylasteriquinone D prenyltransferase [Schneider08], 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) [Funa05], 5'-demethoxy-6-methoxypodophyllotoxin 7-O-glucosyltransferase [Berim08], 6-methoxypodophyllotoxin 7-O-glucosyltransferase [Berim08], podophyllotoxin 7-O-glucosyltransferase [Berim08], paxilline dimethylallyl diphosphate transferase [Liu14d], cellobiose 2-epimerase [Taguchi08], synephrine dehydratase [Manne86], glycerophosphocholine cholinephosphodiesterase [Sugimori13], acyl-CoA:lyso-phosphatidate acyltransferase [Chen07a], acyl-CoA:lyso-phosphatidylcholine acyltransferase [Chen07a], acyl-CoA:lyso-phosphatidylethanolamine acyltransferase [Chen07a], lyso-phosphatidylcholine acyltransferase [Richard98], oleoyl-CoA: lysophosphatidate acyltransferase [Rajakumari10], triacylglycerol lipase [Rajakumari10], oleoyl-CoA:lysophosphatidate acyltransferase [Rajakumari10], oleoyl-CoA:lysophosphatidylethanolamine acyltransferase [Rajakumari10], phosphoribosylpyrophosphate amidotransferase [Satyanarayana71], NADH kinase [Shi05b], NAD(+) kinase [Shi05b], uridine-5'-monophosphate:2-oxoglutarate dioxygenase [Yang11], pyridoxamine 5'-phosphate oxidase [Tsuge82], pyridoxine 5'-phosphate oxidase II [Tsuge82], quercetin 3-O-β-D-galactoside-2"-O-glucosyltransferase [Vogt95], kaempferol 3-O-β-D-galactoside-2"-O-glucosyltransferase [Vogt95], kaempferide 3-O-glucosyltransferase (F3GT2) [Ishikura94], kaempferide 3-O-glucosyltransferase (F3GT1) [Ishikura94], 3,6,7,2',4'-pentamethylquercetagetin 3'-O-glucosyltransferase [Bajaj83], 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin 3'-O-glucosyltransferase [Bajaj83], 3,6,7,4'-tetramethylquercetagetin 3'-O-glucosyltransferase [Bajaj83], 3,7,4'-trimethylquercetagetin 3'-O-glucosyltransferase [Bajaj83], 2'-hydroxy 3,7,3',4'-tetramethylquercetin 2'-O-glucosyltransferase [Bajaj83], 2'-hydroxy 3,7,4'-trimethylquercetin 2'-O-glucosyltransferase [Bajaj83], 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin 3'-O-glucoside 2'-O-methyltransferase [Khouri86], 3,7,4'trimethylquercetin 2'-O-glucoside 3'-O-methyltransferase [Khouri86], 3-O-methylquercetin 7-O-methyltransferase [Khouri88], kaempferol 3-O-glucosyltransferase [Owens], quercetin 3-O-glucosyltransferase [Owens], myricetin 3-O-glucosyltransferase [Owens], 7'-O-demethylcephaeline 7'-O-methyltransferase [Cheong11], omega-hydroxypalmitate O-feruloyl transferase [Rautengarten12], thiobenzoate-S-methyltransferase, phosphoenolpyruvate phosphatase [Tran10], phosphoenolpyruvate phosphatase [Veljanovski06], 2-hydroxy-1,4-benzoquinone reductase [Takenaka11], anol synthase [Koeduka09], eugenol synthase [Koeduka09], SAM:t-anol O-methyltransferase [Koeduka09], isoeugenol synthase [Koeduka06], eugenol synthase [Koeduka06], (+)-germacrene D synthase [Picaud06], UDPG:ginsenoside Rd glucosyltransferase [Yue05], o-dihydric phenol O-methyltransferase (para-methylation) [Tsang79], esculetin 6-O-methyltransferase (meta-methylation) [Tsang79], fumigaclavine A dimethylallyltransferase [Unsold06], esculetin 7-O-glucosyltransferase [Taguchi00], UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase [Yokoyama08], 4-oxalocrotonate tautomerase [Orii06], 2-hydroxymuconate 6-semialdehyde dehydrogenase [Orii06], 2-amino-5-carboxymuconic 6-semialdehyde deaminase [Orii04], 6-hydroxy-3-succinoyl-pyridine hydroxylase [Tang11a], isoprimeverose α-xylosidase [Moracci00], pullulanase [Dong97], L-rhamnono-γ-lactonase [Watanabe08], NAD+-dependent L-rhamnofuranose 1-dehydrogenase [Rigo76], glucosylglycerate synthase [Fernandes10], N-benzylformamide deformylase [Fukatsu04], chondroitin sulfate A endolyase [Hamai97], chondroitin 4-sulfate exolyase [Hamai97], dermatan sulfate exolyase [Hamai97], farnesoic acid carboxyl methyltransferase [Yang06a], 7-methylxanthine demethylase [Gluck88], theobromine N3-demethylase [Asano94, Asano93], pectate lyase [Tardy97], pectate lyase [Tardy97], pectate lyase [Tardy97], GA9 carboxyl methyltransferase [Varbanova07], oxidized polyvinylalcohol hydrolase [Klomklang05], peptidoglycan-N-acetylglucosamine deacetylase [Psylinakis05], L-galactono-γ-lactone dehydrogenase [Shigeoka79], phosphatidylinositol synthase [Antonsson94], phenylacetyl-coenzyme A:glycine N-acyltransferase [Nandi79], β-alanine amide amidase [Komeda04], L-proline amide hydrolase [Komeda04a], 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase [Pucci07], 3-hydroxyanthranilate 3,4-dioxygenase [Calderone02], methyl indole-3-acetate methylesterase, 3-dehydroshikimate dehydratase [Pfleger08], putrescine N-methyltransferase [Hibi92], dihydrocoumarin hydrolase [Kosuge62], hydroxyproline 2-epimerase [Adams64], 4-oxalomesaconate hydratase [Maruyama85], feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase [Yu99], cytidine 5'-monophosphate N-acetylneuraminate synthetase [RodriguezAparic92], ε-N-trimethyllysine hydroxylase [Sachan80], iminodiacetate dehydrogenase [Uetz93], 27-O-demethyl-rifamycin SV methyltransferase [Xu03a], kanosamine 6-kinase [Arakawa02], sterigmatocystin O-methyltransferase [Liu99d], NAD-dependent ATP dehydrogenase [Rubio98], carboxynorspermidine decarboxylase [Nakao90], desoxyhemigossypol-6-O-methyltransferase [Liu99e], (R)-citramalyl-CoA lyase [Friedmann07], triazine hydrolase [Topp00], deacetoxycephalosporin C hydroxylase [Baker91], deacetoxycephalosporin C hydroxylase [Dotzlaf87], deacetoxycephalosporin C synthase [Dotzlaf87], isopenicillin N epimerase [Laiz90], isopenicillin N synthase [Castro88], 3-hydroxyanthranilate 3,4-dioxygenase [Muraki03], succinate semialdehyde dehydrogenase [Chambliss92], S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase [Sato94], 2-pyrone-4,6-dicarboxylate hydrolase [Kersten82], UDPG:nicotinate N-glucosyltransferase [Upmeier88], histidinol dehydrogenase [Nagai91a], myo-inositol-hexakisphosphate 4-phosphohydrolase [Greiner02], porphobilinogen deaminase [Jones94a], myo-inositol-hexakisphosphate 3-phosphohydrolase [Greiner02], glycerol-3-phosphate cytidylyltransferase [Park93], benzoyl-coenzyme A:benzyl alcohol benzoyltransferase [DAuria02], sucrose synthase [Elling95], trehalose synthase [Nishimoto96], ornithine carbamoyltransferase [Morizono97], 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase [Morishige00], glycerol dehydrogenase [Daniel95], maltooligosyl-trehalose trehalohydrolase, lysine N6-acetyltransferase [Bode93], L-lactate dehydrogenase [Wrba90a], L-carnitine dehydrogenase [Mori88], adenylosuccinate synthetase [Ryzhova98], feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase [Hohlfeld95], arginine deiminase [Hill67], trehalose phosphorylase [Kizawa95], kynurenine formamidase [Brown86], L-carnitine dehydrogenase [Hanschmann96], phosphoribosylpyrophosphate amidotransferase [Satyanarayana71], S-adenosyl-L-methionine:isoeugenol-O-methyltransferase [Wang98e], S-adenosyl-L-methionine:eugenol-O-methyltransferase [Wang98e], kynurenine formamidase [Brown86], trehalose synthase [Nishimoto96a], trehalose phosphorylase [Saito98], arogenate dehydratase [Jung86], DL-methylmalonyl-CoA racemase [Stabler85], DIMBOA-glucoside 4-O-methyltransferase [Oikawa02], glutathione peroxidase [Takahashi87], sulfur:ferric ion oxidoreductase [Sugio89], myo-inositol-hexakisphosphate phosphohydrolase [Greiner01], myo-inositol-hexakisphosphate 3-phosphohydrolase [Greiner02], sucrose-phosphate phosphatase [Lunn00], pectin methyltransferase [Ishikawa00], 2-pyrone-4,6-dicarboxylate hydrolase [Maruyama83a], 2-pyrone-4,6-dicarboxylate hydrolase [Masai99], maltooligosyl-trehalose trehalohydrolase [Nakada95], UDP-glucose:phenylacetothiohydroximate glucosyltransferase [Reed93], galactokinase [Dey83], naringenin 7-O-methyltransferase [Rakwal00], 4-coumaroyl-CoA:pelargonidin-3-O-β-D-glucoside-6''-O-acyltransferase [Fujiwara98], isoliquiritigenin 4'-glucosyltransferase [Stich94], butein 4'-glucosyltransferase [Stich94], butein 4'-glucosyltransferase [Halbwirth97], sulfuretin 4'-glucosyltransferase [Halbwirth97], eriodictyol: 2-oxoglutarate oxygen oxidoreductase [Britsch90], naringenin,2-oxoglutarate oxygen oxidoreductase [Britsch90], guanine deaminase [Negishi94], guanosine deaminase [Negishi94], tyrosine 3-monooxygenase [Yamamoto01a], caffeoyl-CoA:pelargonidin-3-O-β-D-glucoside-6''-O-acyltransferase [Fujiwara98], D-galactonate dehydratase [Szumilo81], 4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase [Fujiwara98], δ-aminovaleramidase [Reitz70], Δ1-piperideine-2-carboxylate reductase [Payton82], 4-coumaroyl-CoA:cyanidin-3-O-β-D-glucoside-6''-O-acyltransferase [Fujiwara98], L-sorbosone dehydrogenase [Asakura99], phosphohexose isomerase [Sangwan90], 2-coumarate O-β-glucosyltransferase [Kleinhofs67], caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase [Fujiwara98], anthocyanin 5-O-glucoside-4'''-O-malonyltransferase [Suzuki04], 3-keto-5-aminohexanoate cleavage enzyme [Yorifuji77], acetyl-CoA:salutaridinol-7-O-acetyltransferase [Lenz95], diketodeoxyinositol hydrolase [Berman66], L-asparaginase [Raha90], formimidoyltetrahydrofolate cyclodeaminase [Uyeda67], L-lysine α-oxidase [Weber94a], α-D-galactosyl-(1-3)-1D-myo-inositol:raffinose galactosyltransferase [Peterbauer98], flavone synthase [Britsch90], α-D-galactosyl-(1-3)-1D-myo-inositol:raffinose galactosyltransferase [Gaudreault81], 3,4-dihydroxyphenylacetate dioxygenase [Gibello94] Inhibitor (Other types) of: D-arabinose 5-phosphate isomerase [Lim66, Meredith03, Airoldi10], 6-hydroxy-3-succinoyl-pyridine hydroxylase [Yu15], androsta-1,4-diene-3,17-dione 9α-hydroxylase [Petrusma09], xylan 1,3-β-xylosidase [Umemoto08], acetophenone carboxylase [Jobst10], geranylgeranyl diphosphate diphosphatase [Nualkaew06], (-)-dihydrocarvone monooxygenase, (1S,4R)-iso-dihydrocarvone monooxygenase [Van00], (1R,4S)-iso-dihydrocarvone monooxygenase [Van00], (1R,4R)-dihydrocarvone monooxygenase [Van00], (1R,4S)-1-hydroxy-2-oxolimonene monooxygenase [Van00], cis-aconitate decarboxylase [Bentley57], D-sorbitol dehydrogenase [Yamaguchi94], L-allo-threonine aldolase [Kataoka97], raffinose synthase [Lehle73], β-ketoadipyl CoA thiolase [Kaschabek02]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: acyl carrier protein phosphodiesterase, GTP cyclohydrolase, rhamnulose-1-phosphate aldolase, L-ribulose 5-phosphate 4-epimerase, D-glucuronate isomerase, L-galactitol-1-phosphate 5-dehydrogenase, N-acetylglucosamine-6-phosphate deacetylase, L-galactonate oxidoreductase, anhydro-N-acetylmuramoyl-L-alanine amidase, mannose-6-phosphate isomerase, D-ribulose-phosphate aldolase, L-fuculose-phosphate aldolase, deoxyuridine triphosphatase, acetylornithine deacetylase, allantoinase, cobalamin-independent homocysteine transmethylase, methionine synthase, threonine dehydrogenase, deoxycytidine deaminase, cytidine deaminase, guanine deaminase, glyoxalase II, glyoxalase II, isopentenyl diphosphate isomerase, 3-demethylubiquinone-8 3-O-methyltransferase, 3-dehydroquinate synthase, tRNA-guanine transglycosylase, cysteinyl-tRNA synthetase, glutamyl-tRNA synthetase, isoleucyl-tRNA synthetase, alanyl-tRNA synthetase, threonyl-tRNA synthetase, methionyl-tRNA synthetase, methionyl-tRNA synthetase, porphobilinogen synthase, N-succinyl-L-diaminopimelate desuccinylase, dihydroorotase, 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent, fructose bisphosphate aldolase, formaldehyde dehydrogenase, UDP-glucose:α-D-galactose-1-phosphate uridylyltransferase, carbonic anhydrase, diacylglycerol kinase, dipeptidyl carboxypeptidase, 23S rRNA m1G745 methyltransferase, aminopeptidase, isoaspartyl dipeptidase, tRNA adenosine deaminase, ATP-dependent zinc metalloendoprotease, 5'-ribonucleotidase, UDP-sugar hydrolase, ribonucleoside-triphosphate reductase, aldehyde reductase, alkaline phosphatase, puberulonate decarboxylase, stipitatonate decarboxylase, β-carbonic anhydrase, β-carbonic anhydrase, 5-methylcytosine deaminase, methanol dehydrogenase, Cys-Gly metallodipeptidase, shikimate dehydrogenase, linuron hydrolase, linuron hydrolase, 8-hydroxygeraniol dehydrogenase, D-serine ammonia-lyase, carbonyl sulfide hydrolase, carbon disulfide hydrolase, CysO-cysteine hydrolase, 2,4-didehydro-inositol hydratase, L-iditol dehydrogenase, D-xylitol dehydrogenase, D-sorbitol dehydrogenase, dCMP deaminase, cytidine deaminase, 2'-deoxycytidine deaminase, deoxycytidylate deaminase, deoxycytidylate deaminase, cytidine deaminase, cytosine deaminase, 5-fluorocytosine deaminase, deoxycytidine deaminase, aminoacylase, aspartodeacetylase, aspartoacylase, 2-deoxy-scyllo-inosamine dehydrogenase, methanol:MtaC protein Co-methyltransferase, chitin deacetylase, phosphoenolpyruvate mutase, phosphonoacetate hydrolase, mitochondrial-processing peptidase, neoagarobiose 1,3-α-3,6-anhydro-L-galactosidase, cytidine deaminase, 10-hydroxygeranial oxidoreductase, 10-oxogeraniol oxidoreductase, 10-oxogeraniol dehydrogenase, NADPH-10-oxogeraniol dehydrogenase, 10-hydroxygeraniol oxidoreductase, 10-hydroxygeraniol oxidoreductase, carbon-monoxide dehydrogenase, cellulase, purine nucleosidase, N-acetylphosphatidylethanolamine-hydrolysing phospholipas, 2-keto-3-deoxy-L-rhamnoate aldolase, 7-cyano-7-deazaguanine synthase, S-adenosylhomocysteine deaminase, 5-methylthioadenosine deaminase, phophonoacetaldehyde reductase, acetophenone carboxylase, 4-oxalmesaconate hydratase, (2R)-2-hydroxy-2-methylbutanenitrile lyase, gelatinase A, prenyl protein-specific endoprotease, insulin-like growth factor binding protein-4 protease, N-benzylformamide deformylase, 8-oxoguanine deaminase, ethanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, methanol dehydrogenase, D-alanyl-D-alanine carboxypeptidase, D-alanyl-D-alanine dipeptidase, dihydrouracil amidohydrolase, dihydrothymine amidohydrolase, β-alanine synthase, barbiturate amidohydrolase, hemoglobin metallopeptidase, Glu-Tyr endopeptidase, galactonolactonase, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase, guanine deaminase, IMP 5'-nucleotidase, ammonia monooxygenase, acrylyl-CoA reductase, GTP cyclohydrolase, pseudolysin, carbonic anhydrase, (+)-4-chloromuconolactone hydrolase, trans-4-carboxymethylenebut-2-en-4-olide lactonohydrolase, histidinol phosphate phosphatase, acetylpolyamine amidohydrolase, (R,R)-butanediol dehydrogenase, methylenetetrahydrofolate reductase, biliverdin reductase, enamidase, triazine hydrolase, N-isopropylammelide isopropylaminohydrolase, (R)-2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming), (S)-2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming), acetone carboxylase, gluconolactonase, D-arabinose 1-dehydrogenase, 4-pyridoxolactonase, methylmalonyl-CoA carboxyltransferase, benzyl alcohol dehydrogenase, sulfate adenylyltransferase, isocitrate dehydrogenase, fructose-bisphosphate aldolase, sedoheptulose-1,7-bisphosphate aldolase, parathion hydrolase, MtaC protein: coenzyme M methyltransferase, glyceraldehyde-3-phosphate ferredoxin oxidoreductase, acetyl-CoA decarbonylase/synthase, β-ureidopropionase, butanol dehydrogenase, methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase, N-succinyl-L,L-diaminopimelate desuccinylase, butanol dehydrogenase, creatininase, carbon monoxide dehydrogenase, sulfate adenylyltransferase, phosphonoacetate hydrolase, betaine-homocysteine S-methyltransferase, S-hydroxymethyl-glutathione dehydrogenase, guanidinobutyrase, guanidinobutyrase, arginase

This compound has been characterized as an alternative cofactor or prosthetic group of the following enzymes: NMN adenylyltransferase, methionine adenosyltransferase, cytosine deaminase, carbamoyl phosphate synthetase


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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