MetaCyc Polypeptide: procollagenase

Gene: MMP2 Accession Number: HS01565 (MetaCyc)

Synonyms: CLG4A, 72 kDa gelatinase, gelatinase A, matrix metalloproteinase-2, MMP-2, TBE-1

Species: Homo sapiens

Alternative forms of procollagenase: type IV collagenase (extended summary available)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.

MMP2 is a ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. It degrades gelatin type I and collagen types IV, V, VII, and X. It cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.

The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). The active protein binds 4 calcium ions and 2 zinc ions per subunit. In addition, autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide PEX. This processing appears to be facilitated by binding integrinv/beta3.

Locations: extracellular space

Map Position: [55,478,529 -> 55,595,068]

Molecular Weight of Polypeptide: 73.882 kD (from nucleotide sequence)

Unification Links: ArrayExpress:P08253 , DIP:DIP-26N , Entrez-gene:4313 , PhosphoSite:P08253 , PhylomeDB:P08253 , Pride:P08253 , Protein Model Portal:P08253 , SMR:P08253 , String:9606.ENSP00000219070 , UniProt:P08253

Relationship Links: InterPro:IN-FAMILY:IPR000562 , InterPro:IN-FAMILY:IPR000585 , InterPro:IN-FAMILY:IPR001818 , InterPro:IN-FAMILY:IPR002477 , InterPro:IN-FAMILY:IPR006026 , InterPro:IN-FAMILY:IPR013806 , InterPro:IN-FAMILY:IPR018486 , InterPro:IN-FAMILY:IPR018487 , InterPro:IN-FAMILY:IPR021158 , InterPro:IN-FAMILY:IPR021190 , InterPro:IN-FAMILY:IPR024079 , InterPro:IN-FAMILY:IPR028708 , Panther:IN-FAMILY:PTHR10201:SF29 , PDB:Structure:1CK7 , PDB:Structure:1CXW , PDB:Structure:1EAK , PDB:Structure:1GEN , PDB:Structure:1GXD , PDB:Structure:1HOV , PDB:Structure:1J7M , PDB:Structure:1KS0 , PDB:Structure:1QIB , PDB:Structure:1RTG , PDB:Structure:3AYU , Pfam:IN-FAMILY:PF00040 , Pfam:IN-FAMILY:PF00045 , Pfam:IN-FAMILY:PF00413 , Pfam:IN-FAMILY:PF01471 , Prints:IN-FAMILY:PR00138 , Prosite:IN-FAMILY:PS00023 , Prosite:IN-FAMILY:PS00024 , Prosite:IN-FAMILY:PS00142 , Prosite:IN-FAMILY:PS00546 , Prosite:IN-FAMILY:PS51092 , Prosite:IN-FAMILY:PS51642 , Smart:IN-FAMILY:SM00059 , Smart:IN-FAMILY:SM00120 , Smart:IN-FAMILY:SM00235

Reactions known to produce the compound:

Not in pathways:
a collagenase + H2O → a procollagenase + a peptide

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Cellular Component: GO:0005615 - extracellular space

Created 23-Sep-2010 by Caspi R , SRI International


Schematic showing introns, exons and/or isoforms of MMP2

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, biocyc13.