MetaCyc Enzyme: nicotianamine synthase

Gene: OsNAS2 Accession Number: G-10639 (MetaCyc)

Synonyms: nicotianamine synthase 2

Species: Oryza

A cDNA clone was isolated from rice seedling. The cDNA was recombinantly expressed in transgenic rice plants and shown to be nicotianamine synthase. This enzyme catalyzes the trimerization of SAM into nicotamine [Higuchi01].

Molecular Weight of Polypeptide: 34.4 kD (from nucleotide sequence), 34.4 kD (experimental) [Higuchi01 ]

Unification Links: ArrayExpress:A2XFU5 , Entrez:BAB17823 , String:39947.LOC_Os03g19420.2 , UniProt:A2XFU5

Relationship Links: Entrez-Nucleotide:PART-OF:AB023818 , InterPro:IN-FAMILY:IPR004298 , InterPro:IN-FAMILY:IPR029063 , Pfam:IN-FAMILY:PF03059 , Prosite:IN-FAMILY:PS51142

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 06-May-2008 by Pujar A , Cornell University

Enzymatic reaction of: nicotianamine synthase

EC Number:

3 S-adenosyl-L-methionine <=> L-nicotianamine + 3 S-methyl-5'-thioadenosine + 3 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: L-nicotianamine biosynthesis , 2'-deoxymugineic acid phytosiderophore biosynthesis


Higuchi01: Higuchi K, Watanabe S, Takahashi M, Kawasaki S, Nakanishi H, Nishizawa NK, Mori S (2001). "Nicotianamine synthase gene expression differs in barley and rice under Fe-deficient conditions." Plant J 25(2);159-67. PMID: 11169192

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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