MetaCyc Enzyme: neryl diphosphate synthase

Gene: NPDS1 Accession Number: G-11833 (MetaCyc)

Synonyms: neryl diphosphate synthase 1

Species: Solanum lycopersicum

A cDNA clone was isolated from the glandular trichomes of tomato. The cDNA was recombinantly expressed in E.coli and it encodes a gene named NPDS1. The enzyme catalyzes the conversion of dimethylallyl diphosphate and isopentenyl diphosphate into neryl diphosphate. The expression of the transcript is specific to glandular trichomes [Schilmiller09].

Molecular Weight of Polypeptide: 34.6 kD (experimental) [Schilmiller09 ]

Unification Links: Entrez-Nucleotide:FJ797956 , Entrez:ACO56895 , Protein Model Portal:C1K5M2 , UniProt:C1K5M2

Relationship Links: InterPro:IN-FAMILY:IPR001441 , InterPro:IN-FAMILY:IPR018520 , Panther:IN-FAMILY:PTHR10291 , Pfam:IN-FAMILY:PF01255 , Prosite:IN-FAMILY:PS01066

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 02-Mar-2010 by Pujar A , Boyce Thompson Institute

Enzymatic reaction of: neryl diphosphate synthase

EC Number:

dimethylallyl diphosphate + isopentenyl diphosphate <=> neryl diphosphate + diphosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: trichome monoterpenes biosynthesis


Schilmiller09: Schilmiller AL, Schauvinhold I, Larson M, Xu R, Charbonneau AL, Schmidt A, Wilkerson C, Last RL, Pichersky E (2009). "Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate." Proc Natl Acad Sci U S A 106(26);10865-70. PMID: 19487664

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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