MetaCyc Enzyme: NAD-dependent succinate semialdehyde dehydrogenase

Gene: SSR1 Accession Number: G-11940 (MetaCyc)

Species: Solanum lycopersicum

A cDNA clone was isolated from fresh leaves of Solanum lycopersicum. The cDNA was recombinantly expresed in E.coli. The expressed protein shares identity with succinic semialdehyde reductase. The enzyme catalyzes the conversion of succinate semialdehyde to succinate using NAD+ [Akihiro08].

Molecular Weight of Polypeptide: 30.4 kD (experimental) [Akihiro08 ]

Unification Links: Entrez-Nucleotide:BAG16485 , Entrez:BAG16485 , Protein Model Portal:B1Q3F6 , UniProt:B1Q3F6

Relationship Links: InterPro:IN-FAMILY:IPR006115 , InterPro:IN-FAMILY:IPR008927 , InterPro:IN-FAMILY:IPR013328 , InterPro:IN-FAMILY:IPR015815 , InterPro:IN-FAMILY:IPR016040 , InterPro:IN-FAMILY:IPR029154 , Panther:IN-FAMILY:PTHR22981 , Pfam:IN-FAMILY:PF03446 , Pfam:IN-FAMILY:PF14833

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 31-Mar-2010 by Pujar A , Boyce Thompson Institute

Enzymatic reaction of: succinate semialdehyde dehydrogenase

Synonyms: succinic semialdehyde reductase

EC Number:

succinate semialdehyde + NAD+ + H2O <=> succinate + NADH + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: L-glutamate degradation IV , 4-aminobutanoate degradation I , 4-aminobutanoate degradation IV


Akihiro08: Akihiro T, Koike S, Tani R, Tominaga T, Watanabe S, Iijima Y, Aoki K, Shibata D, Ashihara H, Matsukura C, Akama K, Fujimura T, Ezura H (2008). "Biochemical mechanism on GABA accumulation during fruit development in tomato." Plant Cell Physiol 49(9);1378-89. PMID: 18713763

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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