|Gene:||AKR1E2||Accession Number: G-14931 (MetaCyc)|
Species: Sus scrofa
Glycogen degradation gives rise to 1,5-anhydro-D-fructose which is then reduced to 1, 5-anhydro-D-glucitol in animal livers by an NADPH-dependent enzyme [Sakuma98]. This two step irreversible production of metabolically inactive 1, 5-anhydro-D-glucitol constitutes a third glycogenolytic pathway and may play a role in the control of mammalian glycogen metabolism [Sakuma98].
Molecular Weight of Polypeptide: 34.1 kD (from nucleotide sequence), 38.0 kD (experimental) [Sakuma98 ]
Relationship Links: InterPro:IN-FAMILY:IPR001395 , InterPro:IN-FAMILY:IPR018170 , InterPro:IN-FAMILY:IPR020471 , InterPro:IN-FAMILY:IPR023210 , Panther:IN-FAMILY:PTHR11732 , Pfam:IN-FAMILY:PF00248 , Prints:IN-FAMILY:PR00069 , Prosite:IN-FAMILY:PS00062 , Prosite:IN-FAMILY:PS00063 , Prosite:IN-FAMILY:PS00798
Enzymatic reaction of: 4anhydrofructose reductase (1,5-anhydro-D-fructose reductase)
EC Number: 220.127.116.113
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
The reaction is physiologically favored in the opposite direction.
Sakuma98: Sakuma M, Kametani S, Akanuma H (1998). "Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose." J Biochem 123(1);189-93. PMID: 9504428
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