Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: 1,5-anhydro-D-fructose reductase

Gene: AKR1E2 Accession Number: G-14931 (MetaCyc)

Species: Sus scrofa

Summary:
Glycogen degradation gives rise to 1,5-anhydro-D-fructose which is then reduced to 1, 5-anhydro-D-glucitol in animal livers by an NADPH-dependent enzyme [Sakuma98]. This two step irreversible production of metabolically inactive 1, 5-anhydro-D-glucitol constitutes a third glycogenolytic pathway and may play a role in the control of mammalian glycogen metabolism [Sakuma98].

Molecular Weight of Polypeptide: 34.1 kD (from nucleotide sequence), 38.0 kD (experimental) [Sakuma98 ]

Unification Links: ArrayExpress:P82125 , UniProt:P82125

Relationship Links: InterPro:IN-FAMILY:IPR001395 , InterPro:IN-FAMILY:IPR018170 , InterPro:IN-FAMILY:IPR020471 , InterPro:IN-FAMILY:IPR023210 , Panther:IN-FAMILY:PTHR11732 , Pfam:IN-FAMILY:PF00248 , Prints:IN-FAMILY:PR00069 , Prosite:IN-FAMILY:PS00062 , Prosite:IN-FAMILY:PS00063 , Prosite:IN-FAMILY:PS00798

Gene-Reaction Schematic: ?

Credits:
Created 09-Feb-2012 by Weerasinghe D , SRI International


Enzymatic reaction of: 4anhydrofructose reductase (1,5-anhydro-D-fructose reductase)

EC Number: 1.1.1.263

1,5-anhydro-D-glucitol + NADP+ <=> 1,5-anhydro-D-fructose + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the opposite direction.

Kinetic Parameters:

Substrate
Km (μM)
1,5-anhydro-D-fructose
440.0

pH(opt): 7.0


References

Sakuma98: Sakuma M, Kametani S, Akanuma H (1998). "Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose." J Biochem 123(1);189-93. PMID: 9504428


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC13A.