MetaCyc Enzyme: 1,5-anhydro-D-fructose reductase

Gene: AKR1E2 Accession Number: G-14931 (MetaCyc)

Species: Sus scrofa

Glycogen degradation gives rise to 1,5-anhydro-D-fructose which is then reduced to 1, 5-anhydro-D-glucitol in animal livers by an NADPH-dependent enzyme [Sakuma98]. This two step irreversible production of metabolically inactive 1, 5-anhydro-D-glucitol constitutes a third glycogenolytic pathway and may play a role in the control of mammalian glycogen metabolism [Sakuma98].

Molecular Weight of Polypeptide: 34.1 kD (from nucleotide sequence), 38.0 kD (experimental) [Sakuma98 ]

Unification Links: ArrayExpress:P82125 , UniProt:P82125

Relationship Links: InterPro:IN-FAMILY:IPR001395 , InterPro:IN-FAMILY:IPR018170 , InterPro:IN-FAMILY:IPR020471 , InterPro:IN-FAMILY:IPR023210 , Panther:IN-FAMILY:PTHR11732 , Pfam:IN-FAMILY:PF00248 , Prints:IN-FAMILY:PR00069 , Prosite:IN-FAMILY:PS00062 , Prosite:IN-FAMILY:PS00063 , Prosite:IN-FAMILY:PS00798

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 09-Feb-2012 by Weerasinghe D , SRI International

Enzymatic reaction of: 4anhydrofructose reductase (1,5-anhydro-D-fructose reductase)

EC Number:

1,5-anhydro-D-glucitol + NADP+ <=> 1,5-anhydro-D-fructose + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the opposite direction.

Kinetic Parameters:

Km (μM)

pH(opt): 7.0


Sakuma98: Sakuma M, Kametani S, Akanuma H (1998). "Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose." J Biochem 123(1);189-93. PMID: 9504428

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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