Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Enzyme: Δ1-pyrroline-5-carboxylate dehydrogenase

Gene: put2 Accession Number: G-447 (MetaCyc)

Species: Saccharomyces cerevisiae

Summary:
Δ1-Pyrroline-5-carboxylate dehydrogenase catalyzes the second reaction in proline utilization in Saccharomyces cerevisiae. The two-step pathway takes place inside the mitochondria. The enzyme is encoded in the nucleus, synthesized in the cytoplasm and imported to the mitochondria [Brandriss83, Brandriss79].

Locations: mitochondrial lumen

Molecular Weight of Polypeptide: 64.435 kD (from nucleotide sequence)

Unification Links: Mint:MINT-640995 , ModBase:P07275 , Protein Model Portal:P07275 , SMR:P07275 , String:4932.YHR037W , Swiss-Model:P07275 , UniProt:P07275

Relationship Links: InterPro:IN-FAMILY:IPR005931 , InterPro:IN-FAMILY:IPR015590 , InterPro:IN-FAMILY:IPR016160 , InterPro:IN-FAMILY:IPR016161 , InterPro:IN-FAMILY:IPR016162 , InterPro:IN-FAMILY:IPR016163 , Pfam:IN-FAMILY:PF00171 , Prosite:IN-FAMILY:PS00070 , Prosite:IN-FAMILY:PS00687

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005759 - mitochondrial matrix [Brandriss81]


Enzymatic reaction of: Δ1-pyrroline-5-carboxylate dehydrogenase

Synonyms: P5C dehydrogenase

EC Number: 1.2.1.88

L-glutamate-5-semialdehyde + NAD+ + H2O <=> L-glutamate + NADH + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is irreversible in the direction shown.

In Pathways: proline degradation


References

Brandriss79: Brandriss MC, Magasanik B (1979). "Genetics and physiology of proline utilization in Saccharomyces cerevisiae: enzyme induction by proline." J Bacteriol 1979;140(2);498-503. PMID: 387737

Brandriss81: Brandriss MC, Magasanik B (1981). "Subcellular compartmentation in control of converging pathways for proline and arginine metabolism in Saccharomyces cerevisiae." J Bacteriol 145(3);1359-64. PMID: 7009582

Brandriss83: Brandriss MC (1983). "Proline utilization in Saccharomyces cerevisiae: analysis of the cloned PUT2 gene." Mol Cell Biol 1983;3(10);1846-56. PMID: 6358862


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 20, 2014, BIOCYC14A.