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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Polypeptide: HPr

Synonyms: Hpr, Ctr, PtsH

Alternative forms of HPr: HPr - phosphorylated

Citations: [vanNuland92, Jia93, Koch96, Reichenbach07, Kundig71]

Locations: cytoplasm

Unification Links: DIP:DIP-35731N , EcoliWiki:b2415 , Mint:MINT-8085981 , ModBase:P0AA04 , PR:PRO_000023632 , Pride:P0AA04 , Protein Model Portal:P0AA04 , RefSeq:NP_416910 , SMR:P0AA04 , String:511145.b2415 , UniProt:P0AA04

Relationship Links: InterPro:IN-FAMILY:IPR000032 , InterPro:IN-FAMILY:IPR001020 , InterPro:IN-FAMILY:IPR002114 , InterPro:IN-FAMILY:IPR005698 , PDB:Structure:1CM2 , PDB:Structure:1CM3 , PDB:Structure:1GGR , PDB:Structure:1HDN , PDB:Structure:1J6T , PDB:Structure:1OPD , PDB:Structure:1PFH , PDB:Structure:1POH , PDB:Structure:1VRC , PDB:Structure:2JEL , PDB:Structure:2LRK , PDB:Structure:2LRL , PDB:Structure:2XDF , PDB:Structure:3CCD , PDB:Structure:3EZA , PDB:Structure:3EZB , PDB:Structure:3EZE , Pfam:IN-FAMILY:PF00381 , Prints:IN-FAMILY:PR00107 , Prosite:IN-FAMILY:PS00369 , Prosite:IN-FAMILY:PS00589 , Prosite:IN-FAMILY:PS51350

In Transport reactions:
HPr-Phis15 + 2-O-α-mannosyl-D-glycerate[periplasmic space] → 2-O-(6-phospho-α-D-mannosyl)-D-glycerate[cytosol] + HPr ,
HPr-Phis15 + β-D-glucose[periplasmic space] → β-D-glucose 6-phosphate[cytosol] + HPr ,
HPr-Phis15 + L-ascorbate[out] → L-ascorbate 6-phosphate[in] + HPr ,
HPr-Phis15 + salicin[periplasmic space] → salicin 6-phosphate[cytosol] + HPr ,
2-deoxy-D-glucose[periplasmic space] + HPr-Phis15 → 2-deoxy-D-glucose 6-phosphate[cytosol] + HPr

GO Terms:

Biological Process: GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system Inferred from experiment Inferred by computational analysis [UniProtGOA11a, GOA01a, Kundig71]
GO:0043085 - positive regulation of catalytic activity Inferred from experiment [Seok97]
GO:0045819 - positive regulation of glycogen catabolic process Inferred from experiment [Seok97]
GO:0016310 - phosphorylation Inferred by computational analysis [UniProtGOA11a]
Molecular Function: GO:0008047 - enzyme activator activity Inferred from experiment [Seok97]
GO:0008965 - phosphoenolpyruvate-protein phosphotransferase activity Inferred from experiment [Kundig71]
GO:0016301 - kinase activity Inferred from experiment Inferred by computational analysis [UniProtGOA11a, Anderson71]
GO:0005351 - sugar:proton symporter activity Inferred by computational analysis [GOA01a]
Cellular Component: GO:0019197 - phosphoenolpyruvate-dependent sugar phosphotransferase complex Inferred from experiment [Kundig71]

Credits:
Imported from EcoCyc 06-Feb-2013 by Paley S , SRI International


References

Anderson71: Anderson B, Weigel N, Kundig W, Roseman S (1971). "Sugar transport. 3. Purification and properties of a phosphocarrier protein (HPr) of the phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli." J Biol Chem 246(22);7023-33. PMID: 4942330

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Jia93: Jia Z, Quail JW, Waygood EB, Delbaere LT (1993). "The 2.0-A resolution structure of Escherichia coli histidine-containing phosphocarrier protein HPr. A redetermination." J Biol Chem 268(30);22490-501. PMID: 8226757

Koch96: Koch S, Sutrina SL, Wu LF, Reizer J, Schnetz K, Rak B, Saier MH (1996). "Identification of a site in the phosphocarrier protein, HPr, which influences its interactions with sugar permeases of the bacterial phosphotransferase system: kinetic analyses employing site-specific mutants." J Bacteriol 178(4);1126-33. PMID: 8576048

Kundig71: Kundig W, Roseman S (1971). "Sugar transport. I. Isolation of a phosphotransferase system from Escherichia coli." J Biol Chem 246(5);1393-406. PMID: 5545082

Reichenbach07: Reichenbach B, Breustedt DA, Stulke J, Rak B, Gorke B (2007). "Genetic dissection of specificity determinants in the interaction of HPr with enzymes II of the bacterial phosphoenolpyruvate:sugar phosphotransferase system in Escherichia coli." J Bacteriol 189(13);4603-13. PMID: 17449611

Seok97: Seok YJ, Sondej M, Badawi P, Lewis MS, Briggs MC, Jaffe H, Peterkofsky A (1997). "High affinity binding and allosteric regulation of Escherichia coli glycogen phosphorylase by the histidine phosphocarrier protein, HPr." J Biol Chem 272(42);26511-21. PMID: 9334229

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

vanNuland92: van Nuland NA, Grotzinger J, Dijkstra K, Scheek RM, Robillard GT (1992). "Determination of the three-dimensional solution structure of the histidine-containing phosphocarrier protein HPr from Escherichia coli using multidimensional NMR spectroscopy." Eur J Biochem 210(3);881-91. PMID: 1483471


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, BIOCYC13A.