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MetaCyc Enzyme: C-14 sterol reductase

Gene: ERG24 Accession Number: YNL280C (MetaCyc)

Species: Saccharomyces cerevisiae

Summary:
C-14 sterol reductase catalyzes a reduction reaction in the pathway for ergosterol biosynthesis. The ERG24 gene encoding the protein was identified and cloned by complementation of a mutant defective in ergosterol biosynthesis [Lorenz92]. Inactivation of ERG24 is conditionally lethal - mutants can't grow on glucose, but they are able to grow on certain defined media, producing ignosterol instead of ergosterol [Crowley96].

Map Position: [109,093 <- 110,409] (13.91 centisomes)

Molecular Weight of Polypeptide: 50.615 kD (from nucleotide sequence)

Unification Links: DIP:DIP-5155N , Mint:MINT-507875 , Protein Model Portal:P32462 , SGD:S000005224 , String:4932.YNL280C , UniProt:P32462

Relationship Links: Entrez-Nucleotide:PART-OF:M99419 , InterPro:IN-FAMILY:IPR001171 , InterPro:IN-FAMILY:IPR018083 , Pfam:IN-FAMILY:PF01222 , Prosite:IN-FAMILY:PS01017 , Prosite:IN-FAMILY:PS01018

Gene-Reaction Schematic: ?

Gene Class: UNCLASSIFIED

Credits:
Created 21-Dec-2004 by Hong E , Saccharomyces Genome Database


Enzymatic reaction of: C-14 sterol reductase

Synonyms: Δ(14)-sterol reductase

4,4-dimethylzymosterol + NADP+ <=> 14-demethyllanosterol + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the opposite direction.

In Pathways: superpathway of ergosterol biosynthesis I , zymosterol biosynthesis

Inhibitors (Unknown Mechanism): fenpropimorph


References

Crowley96: Crowley JH, Smith SJ, Leak FW, Parks LW (1996). "Aerobic isolation of an ERG24 null mutant of Saccharomyces cerevisiae." J Bacteriol 178(10);2991-3. PMID: 8631695

Lorenz92: Lorenz RT, Parks LW (1992). "Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiae." DNA Cell Biol 11(9);685-92. PMID: 1418625


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Tue Mar 3, 2015, biocyc11.