MetaCyc Enzyme: tetraketide α-pyrone reductase

Gene: TKPR1 Accession Number: AT4G35420 (MetaCyc)

Synonyms: At4G35420

Species: Arabidopsis thaliana col

Unification Links: PhylomeDB:Q500U8 , Pride:Q500U8 , Protein Model Portal:Q500U8 , SMR:Q500U8 , String:3702.AT4G35420.1-P , UniProt:Q500U8

Relationship Links: InterPro:IN-FAMILY:IPR001509 , InterPro:IN-FAMILY:IPR016040 , Pfam:IN-FAMILY:PF01370

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 25-Feb-2011 by Zhang P , TAIR

Enzymatic reaction of: tetraketide α-pyrone reductase

EC Number: 1.1.1.-

a polyhydroxylated tetraketide α-pyrone + NADP+ <=> a hydroxylated tetraketide α-pyrone + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: sporopollenin precursor biosynthesis

Recombinant proteins of TKPR1 and TKPR2, expressed in E. coli, showed catalytic activity towards tetraketide but not triketide α-pyrones. TKPR2 is more active than TKPR1.

TKPR1 and TKPR2 are specifically expressed in tapetum cells and they are tightly co-expressed with ACOS5, PKSA and PKSB. Mutants of TKPR1 or TKPR2 showed defects in pollen exine layer.

Citations: [Grienenberger10]


Grienenberger10: Grienenberger E, Kim SS, Lallemand B, Geoffroy P, Heintz D, Souza Cde A, Heitz T, Douglas CJ, Legrand M (2010). "Analysis of TETRAKETIDE α-PYRONE REDUCTASE function in Arabidopsis thaliana reveals a previously unknown, but conserved, biochemical pathway in sporopollenin monomer biosynthesis." Plant Cell 22(12);4067-83. PMID: 21193572

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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