Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: methionine adenosyltransferase 2

Gene: sam2 Accession Number: G-467 (MetaCyc)

Synonyms: S-adenosylmethionine synthetase 2, AdoMet synthase 2

Species: Saccharomyces cerevisiae

Subunit composition of methionine adenosyltransferase 2 = [Sam2]4

Summary:
The subunit composition is not entirely clear. There are conflicting data. It is known that the subunit structure is tetrameric. The structure is represented here as homotetrameric for simplicity. [Thomas97]

Molecular Weight of Polypeptide: 42.124 kD (from nucleotide sequence) [Bairoch, 1993 ]

Unification Links: DIP:DIP-4001N , Mint:MINT-476096 , ModBase:P19358 , Pride:P19358 , Protein Model Portal:P19358 , SMR:P19358 , String:4932.YDR502C , Swiss-Model:P19358 , UniProt:P19358

Relationship Links: InterPro:IN-FAMILY:IPR002133 , InterPro:IN-FAMILY:IPR022628 , InterPro:IN-FAMILY:IPR022629 , InterPro:IN-FAMILY:IPR022630 , InterPro:IN-FAMILY:IPR022631 , InterPro:IN-FAMILY:IPR022636 , Panther:IN-FAMILY:PTHR11964 , Pfam:IN-FAMILY:PF00438 , Pfam:IN-FAMILY:PF02772 , Pfam:IN-FAMILY:PF02773 , Prosite:IN-FAMILY:PS00376 , Prosite:IN-FAMILY:PS00377

Gene-Reaction Schematic: ?


Enzymatic reaction of: methionine adenosyltransferase

Synonyms: AdoMet synthase, methionine adenosyltransferase

EC Number: 2.5.1.6

ATP + L-methionine + H2O <=> S-adenosyl-L-methionine + phosphate + diphosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is irreversible in the direction shown.

In Pathways: methionine degradation I (to homocysteine) , S-adenosyl-L-methionine biosynthesis

Summary:
S-Adenosylmethionine synthetase 2 is one of two S. cerevisiae enzymes that catalyzes the formation of S-adenosylmethionine. Each enzyme is active independently. [Thomas97, Thomas88, Thomas91]


References

Bairoch, 1993: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Thomas88: Thomas D, Rothstein R, Rosenberg N, Surdin-Kerjan Y (1988). "SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes." Mol Cell Biol 1988;8(12);5132-9. PMID: 3072475

Thomas91: Thomas D, Surdin-Kerjan Y (1991). "The synthesis of the two S-adenosyl-methionine synthetases is differently regulated in Saccharomyces cerevisiae." Mol Gen Genet 1991;226(1-2);224-32. PMID: 1903502

Thomas97: Thomas D, Surdin-Kerjan Y (1997). "Metabolism of sulfur amino acids in Saccharomyces cerevisiae." Microbiol Mol Biol Rev 61(4);503-32. PMID: 9409150


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc13.