Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
twitter

MetaCyc Enzyme: 6-deoxy-5-ketofructose 1-phosphate synthase

Gene: MJ1585 Accession Number: G-11159 (MetaCyc)

Species: Methanocaldococcus jannaschii

Subunit composition of 6-deoxy-5-ketofructose 1-phosphate synthase = [MJ1585]
         fructose 1,6-bisphosphate aldolase monomer = MJ1585

Summary:
The 6-deoxy-5-ketofructose 1-phosphate synthase encoded by the MJ1585 gene has not been purified from Methanocaldococcus jannaschii. However, its activity was proven using labeled isotope studies [White06]. It has been suggested that this enzyme catalyzes the transaldolase reaction between methylglyoxal and a hexose-phosphate, as well as the reaction used in glycolysis (EC 4.1.2.13), and that this archaeal enzyme is specifically involved in aromatic acid biosynthesis [White06].

Molecular Weight of Polypeptide: 34.574 kD (from nucleotide sequence)

Unification Links: Entrez-gene:1452494 , Protein Model Portal:Q58980 , String:243232.MJ1585 , UniProt:Q58980

Relationship Links: InterPro:IN-FAMILY:IPR002915 , InterPro:IN-FAMILY:IPR013785 , Pfam:IN-FAMILY:PF01791

Gene-Reaction Schematic: ?

Credits:
Created 16-Mar-2009 by Caspi R , SRI International


Enzymatic reaction of: D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-forming) (6-deoxy-5-ketofructose 1-phosphate synthase)

EC Number: 2.2.1.11

β-D-fructofuranose 1-phosphate + methylglyoxal <=> 6-deoxy-5-ketofructose 1-phosphate + D-glyceraldehyde

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Reversibility of this reaction is unspecified.


Enzymatic reaction of: fructose 1,6-bisphosphate aldolase (6-deoxy-5-ketofructose 1-phosphate synthase)

EC Number: 2.2.1.11

fructose 1,6-bisphosphate + methylglyoxal <=> 6-deoxy-5-ketofructose 1-phosphate + D-glyceraldehyde 3-phosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: chorismate biosynthesis II (archaea) , 3-dehydroquinate biosynthesis II (archaea)


Enzymatic reaction of: D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming) (6-deoxy-5-ketofructose 1-phosphate synthase)

EC Number: 4.1.2.13

fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

This reaction is reversible.


References

White06: White RH, Xu H (2006). "Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii." Biochemistry 45(40);12366-79. PMID: 17014089


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC13B.