MetaCyc Enzyme: pyruvate, water dikinase

Species: Desulfobacter hydrogenophilus

Subunit composition of pyruvate, water dikinase = [pyruvate, water dikinase monomer]

Information on the subunit structure of this protein from Desulfobacter hydrogenophilus is not available.

Locations: cytosol

In Reactions of unknown directionality:

Not in pathways:
a pyruvate,water dikinase + ADP = [a pyruvate, water dikinase]-phosphate + AMP + H+
[a pyruvate, water dikinase]-phosphate + phosphate + H+ = a pyruvate,water dikinase + diphosphate

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Cellular Component: GO:0005829 - cytosol [Schauder87a]

Enzymatic reaction of: pyruvate, water dikinase

Synonyms: phosphoenolpyruvate synthase

EC Number:

pyruvate + ATP + H2O <=> phosphoenolpyruvate + AMP + phosphate + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is physiologically favored in the direction shown.

In Pathways: reductive TCA cycle I

This reaction forms phosphoenolpyruvate, required for gluconeogenesis [Beh93]. Enzyme activity was assayed in cell-free extracts at 30 deg. C, under anaerobic conditions [Schauder87a].


Beh93: Beh M, Strauss G, Huber R, Stetter K-O, Fuchs G (1993). "Enzymes of the reductive citric acid cycle in the autotrophic eubacterium Aquifex pyrophilus and in the archaebacterium Thermoproteus neutrophilus." Arch Microbiol 160: 306-311.

Schauder87a: Schauder R, Widdel F, Fuchs G (1987). "Carbon assimilation pathways in sulfate-reducing bacteria II. Enzymes of a reductive citric acid cycle in the autotrophic Desulfobacter hydrogenophilus." Arch Microbiol 148: 218-225.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, biocyc12.