MetaCyc Enzyme: pyruvate, water dikinase

Species: Desulfobacter hydrogenophilus

Subunit composition of pyruvate, water dikinase = [pyruvate, water dikinase monomer]

Information on the subunit structure of this protein from Desulfobacter hydrogenophilus is not available.

Locations: cytosol

In Reactions of unknown directionality:

Not in pathways:
a pyruvate,water dikinase + ADP = [a pyruvate, water dikinase]-phosphate + AMP + H+
[a pyruvate, water dikinase]-phosphate + phosphate + H+ = a pyruvate,water dikinase + diphosphate

Gene-Reaction Schematic

Gene-Reaction Schematic

GO Terms:
Cellular Component:
GO:0005829 - cytosol [Schauder87]

Enzymatic reaction of: pyruvate, water dikinase

Inferred from experiment

Synonyms: phosphoenolpyruvate synthase

EC Number:

pyruvate + ATP + H2O → phosphoenolpyruvate + AMP + phosphate + 2 H+

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction of enzyme catalysis.

The reaction is physiologically favored in the direction shown.

In Pathways: reductive TCA cycle I

This reaction forms phosphoenolpyruvate, required for gluconeogenesis [Beh93]. Enzyme activity was assayed in cell-free extracts at 30 deg. C, under anaerobic conditions [Schauder87].


Beh93: Beh M, Strauss G, Huber R, Stetter K-O, Fuchs G (1993). "Enzymes of the reductive citric acid cycle in the autotrophic eubacterium Aquifex pyrophilus and in the archaebacterium Thermoproteus neutrophilus." Arch Microbiol 160: 306-311.

Schauder87: Schauder R, Widdel F, Fuchs G (1987). "Carbon assimilation pathways in sulfate-reducing bacteria II. Enzymes of a reductive citric acid cycle in the autotrophic Desulfobacter hydrogenophilus." Arch Microbiol 148: 218-225.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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