MetaCyc Transporter: copper-transporting ATPase

Gene: HMA5 Accession Number: G-11073 (MetaCyc)

Synonyms: copper-transporting ATPase 3

Species: Arabidopsis thaliana col

Copper is an essential nutrient for electron transport processes, but also very toxic when present in excess, necessitating precise delivery systems. The chloroplast is a major sink for Cu in plants because Cu is an important cofactor for the photosynthetic electron transport. Plastocyanin, a blue copper protein that is one of the most abundant proteins in the thylakoid lumen, catalyzes electron transfer between the cytochrome b6f complex and photosystem I.

A cDNA clone was isolated from Arabidopsis by (RT) PCR and was shown to encode a protein of 995 amino acids. The gene, which was nameed HMA5, has all the main signatures of P-type ATPases with 8 transmembrane domains, two amino terminal metal-binding domains and an ion transduction motif. The protein is mainly expressed in roots and flowers [Kobayashi08].

Molecular Weight of Polypeptide: 108.2 kD (experimental) [Kobayashi08 ]

Unification Links: Entrez:AAF19707.1 , PhylomeDB:Q9SH30 , Pride:Q9SH30 , Protein Model Portal:Q9SH30 , SMR:Q9SH30 , String:Q9SH30 , UniProt:Q9SH30

Relationship Links: Entrez-Nucleotide:PART-OF:AC008047 , InterPro:IN-FAMILY:IPR001757 , InterPro:IN-FAMILY:IPR006121 , InterPro:IN-FAMILY:IPR006122 , InterPro:IN-FAMILY:IPR008250 , InterPro:IN-FAMILY:IPR017969 , InterPro:IN-FAMILY:IPR018303 , InterPro:IN-FAMILY:IPR023214 , InterPro:IN-FAMILY:IPR023299 , InterPro:IN-FAMILY:IPR027256 , Panther:IN-FAMILY:PTHR24093 , Panther:IN-FAMILY:PTHR24093:SF42 , Pfam:IN-FAMILY:PF00122 , Pfam:IN-FAMILY:PF00403 , Pfam:IN-FAMILY:PF00702 , Prints:IN-FAMILY:PR00119 , Prosite:IN-FAMILY:PS00154 , Prosite:IN-FAMILY:PS01047 , Prosite:IN-FAMILY:PS50846

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 19-Feb-2009 by Pujar A , Boyce Thompson Institute

Enzymatic reaction of: copper-transporting ATPase

Synonyms: copper-transporting ATPase 3

EC Number:

Transport reaction diagram for copper-transporting ATPase


Kobayashi08: Kobayashi Y, Kuroda K, Kimura K, Southron-Francis JL, Furuzawa A, Kimura K, Iuchi S, Kobayashi M, Taylor GJ, Koyama H (2008). "Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the mechanism of copper tolerance variation in Arabidopsis." Plant Physiol 148(2);969-80. PMID: 18701674

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, biocyc11.