MetaCyc Enzyme: taurine:pyruvate aminotransferase

Synonyms: Tpa

Species: Pseudomonas aeruginosa TAU-5

Taurine:pyruvate aminotransferase (Tpa) appears to be responsible for the transamination of taurine and pyruvate resulting in the formation of L-alanine and sulfoacetaldehyde in the taurine catabolism pathway of Pseudomonas aeruginosa. The enzyme was partially purified and through mutant studies was shown to be essential for growth with taurine. The enzyme is induced by taurine [Shimamoto79].

Locations: cytosol

Gene-Reaction Schematic

Gene-Reaction Schematic

GO Terms:
Cellular Component:
GO:0005829 - cytosol []

Enzymatic reaction of: taurine:pyruvate aminotransferase

Inferred from experiment

EC Number:

pyruvate + taurine → L-alanine + sulfoacetaldehyde

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

This reaction is reversible.

In Pathways: taurine degradation I


Shimamoto79: Shimamoto G, Berk RS (1979). "Catabolism of taurine in Pseudomonas aeruginosa." Biochim Biophys Acta 569(2);287-92. PMID: 113035

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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