MetaCyc Enzyme: taurine-pyruvate aminotransferase

Gene: tpa Accession Number: G-2723 (MetaCyc)

Species: Rhodococcus opacus

The enzyme was purified to a level of >95% purity by an anion-exchange column. It's identity was confirmed by sequencing the N-terminal 7 amino acids. This sequence (MDVTELR) was identical with the sequence deduced from the tpa gene. The enzyme catalyzed both the conversion of taurine to alanine, and the reverse reaction, in which sulfoacetaldehyde disappeared [Denger04].

Locations: cytosol

Molecular Weight of Polypeptide: 50.0 kD (from nucleotide sequence), 50 kD (experimental) [Denger04 ]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Cellular Component: GO:0005829 - cytosol [Denger04]

Enzymatic reaction of: taurine-pyruvate aminotransferase

EC Number:

pyruvate + taurine <=> L-alanine + sulfoacetaldehyde

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

In Pathways: superpathway of taurine degradation , taurine degradation I

Kinetic Parameters:

Km (μM)


Denger04: Denger K, Ruff J, Schleheck D, Cook AM (2004). "Rhodococcus opacus expresses the xsc gene to utilize taurine as a carbon source or as a nitrogen source but not as a sulfur source." Microbiology 150(Pt 6);1859-67. PMID: 15184572

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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