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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Enzyme: taurine-pyruvate aminotransferase

Gene: tpa Accession Number: G-2723 (MetaCyc)

Species: Rhodococcus opacus

Summary:
The enzyme was purified to a level of >95% purity by an anion-exchange column. It's identity was confirmed by sequencing the N-terminal 7 amino acids. This sequence (MDVTELR) was identical with the sequence deduced from the tpa gene. The enzyme catalyzed both the conversion of taurine to alanine, and the reverse reaction, in which sulfoacetaldehyde disappeared [Denger04].

Locations: cytosol

Molecular Weight of Polypeptide: 50.0 kD (from nucleotide sequence), 50 kD (experimental) [Denger04 ]

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005829 - cytosol [Denger04]


Enzymatic reaction of: taurine-pyruvate aminotransferase

EC Number: 2.6.1.77

pyruvate + taurine <=> L-alanine + sulfoacetaldehyde

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

In Pathways: superpathway of taurine degradation , taurine degradation I

Kinetic Parameters:

Substrate
Km (μM)
Citations
taurine
42000.0
[Denger04]


References

Denger04: Denger K, Ruff J, Schleheck D, Cook AM (2004). "Rhodococcus opacus expresses the xsc gene to utilize taurine as a carbon source or as a nitrogen source but not as a sulfur source." Microbiology 150(Pt 6);1859-67. PMID: 15184572


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC13B.