MetaCyc Enzyme: tetraketide α-pyrone reductase

Gene: TKPR2 Accession Number: AT1G68540 (MetaCyc)

Synonyms: At1G68540

Species: Arabidopsis thaliana col

Recombinant proteins of TKPR1 and TKPR2, expressed in E. coli, showed catalytic activity towards tetraketide but not triketide α-pyrones. TKPR2 is more active than TKPR1.

TKPR1 and TKPR2 are specifically expressed in tapetum cells and they are tightly co-expressed with ACOS5, PKSA and PKSB. Mutants of TKPR1 or TKPR2 showed defects in pollen exine layer [Grienenberger10].

Unification Links: ArrayExpress:Q9CA28 , PhylomeDB:Q9CA28 , Pride:Q9CA28 , Protein Model Portal:Q9CA28 , SMR:Q9CA28 , String:3702.AT1G68540.1-P , UniProt:Q9CA28

Relationship Links: InterPro:IN-FAMILY:IPR001509 , InterPro:IN-FAMILY:IPR016040 , Pfam:IN-FAMILY:PF01370

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a polyhydroxylated tetraketide α-pyrone + NADP+ = a hydroxylated tetraketide α-pyrone + NADPH + H+] (1.1.1.-):
i1: 2-(2,8-dihydroxytridecyl)-6-oxopyran-4-olate + NADP+ ← 2-(8-hydroxy-2-oxotridecyl)-6-oxopyran-4-olate + NADPH + H+ (1.1.1.-)

Created 25-Feb-2011 by Zhang P , TAIR

Enzymatic reaction of: tetraketide α-pyrone reductase

EC Number: 1.1.1.-

a polyhydroxylated tetraketide α-pyrone + NADP+ <=> a hydroxylated tetraketide α-pyrone + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Reversibility of this reaction is unspecified.

In Pathways: sporopollenin precursors biosynthesis


Grienenberger10: Grienenberger E, Kim SS, Lallemand B, Geoffroy P, Heintz D, Souza Cde A, Heitz T, Douglas CJ, Legrand M (2010). "Analysis of TETRAKETIDE α-PYRONE REDUCTASE function in Arabidopsis thaliana reveals a previously unknown, but conserved, biochemical pathway in sporopollenin monomer biosynthesis." Plant Cell 22(12);4067-83. PMID: 21193572

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, biocyc14.