Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: tetraketide α-pyrone reductase

Gene: TKPR2 Accession Number: AT1G68540 (MetaCyc)

Synonyms: At1G68540

Species: Arabidopsis thaliana col

Unification Links: ArrayExpress:Q9CA28 , PhylomeDB:Q9CA28 , Pride:Q9CA28 , Protein Model Portal:Q9CA28 , SMR:Q9CA28 , String:3702.AT1G68540.1-P , UniProt:Q9CA28

Relationship Links: InterPro:IN-FAMILY:IPR001509 , InterPro:IN-FAMILY:IPR016040 , Pfam:IN-FAMILY:PF01370

Gene-Reaction Schematic: ?

Credits:
Created 25-Feb-2011 by Zhang P , TAIR


Enzymatic reaction of: tetraketide α-pyrone reductase

a hydroxylated tetraketide α-pyrone + 2 NADPH <=> a polyhydroxylated tetraketide α-pyrone + 2 NADP+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: sporopollenin precursor biosynthesis

Summary:
Recombinant proteins of TKPR1 and TKPR2, expressed in E. coli, showed catalytic activity towards tetraketide but not triketide α-pyrones. TKPR2 is more active than TKPR1.

TKPR1 and TKPR2 are specifically expressed in tapetum cells and they are tightly co-expressed with ACOS5, PKSA and PKSB. Mutants of TKPR1 or TKPR2 showed defects in pollen exine layer.

Citations: [Grienenberger10]


References

Grienenberger10: Grienenberger E, Kim SS, Lallemand B, Geoffroy P, Heintz D, Souza Cde A, Heitz T, Douglas CJ, Legrand M (2010). "Analysis of TETRAKETIDE α-PYRONE REDUCTASE function in Arabidopsis thaliana reveals a previously unknown, but conserved, biochemical pathway in sporopollenin monomer biosynthesis." Plant Cell 22(12);4067-83. PMID: 21193572


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC14A.