Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
twitter

MetaCyc Enzyme: tetraketide α-pyrone reductase

Gene: TKPR2 Accession Number: AT1G68540 (MetaCyc)

Synonyms: At1G68540

Species: Arabidopsis thaliana col

Summary:
Recombinant proteins of TKPR1 and TKPR2, expressed in E. coli, showed catalytic activity towards tetraketide but not triketide α-pyrones. TKPR2 is more active than TKPR1.

TKPR1 and TKPR2 are specifically expressed in tapetum cells and they are tightly co-expressed with ACOS5, PKSA and PKSB. Mutants of TKPR1 or TKPR2 showed defects in pollen exine layer [Grienenberger10].

Unification Links: ArrayExpress:Q9CA28 , PhylomeDB:Q9CA28 , Pride:Q9CA28 , Protein Model Portal:Q9CA28 , SMR:Q9CA28 , String:3702.AT1G68540.1-P , UniProt:Q9CA28

Relationship Links: InterPro:IN-FAMILY:IPR001509 , InterPro:IN-FAMILY:IPR016040 , Pfam:IN-FAMILY:PF01370

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a polyhydroxylated tetraketide α-pyrone + NADP+ = a hydroxylated tetraketide α-pyrone + NADPH + H+] (1.1.1.-):
i1: 2-(2,8-dihydroxytridecyl)-6-oxopyran-4-olate + NADP+ ← 2-(8-hydroxy-2-oxotridecyl)-6-oxopyran-4-olate + NADPH + H+ (1.1.1.-)

Credits:
Created 25-Feb-2011 by Zhang P , TAIR


Enzymatic reaction of: tetraketide α-pyrone reductase

EC Number: 1.1.1.-

a polyhydroxylated tetraketide α-pyrone + NADP+ <=> a hydroxylated tetraketide α-pyrone + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Reversibility of this reaction is unspecified.

In Pathways: sporopollenin precursors biosynthesis


References

Grienenberger10: Grienenberger E, Kim SS, Lallemand B, Geoffroy P, Heintz D, Souza Cde A, Heitz T, Douglas CJ, Legrand M (2010). "Analysis of TETRAKETIDE α-PYRONE REDUCTASE function in Arabidopsis thaliana reveals a previously unknown, but conserved, biochemical pathway in sporopollenin monomer biosynthesis." Plant Cell 22(12);4067-83. PMID: 21193572


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Sep 4, 2015, biocyc13.