MetaCyc Enzyme: ferric chelate reductase

Gene: OsFRO2 Accession Number: G-10685 (MetaCyc)

Species: Oryza sativa

A cDNA clone encoding a putative ferric chelate reductase OsFRO2 was isolated from Oryza. Northern blot analysis showed that transcripts are expressed only in leaves of Fe-deficient rice plants. The reductase activity is beleived to be impaired based on imperfectly conserved cofactor-binding motifs [Ishimaru06].

Molecular Weight of Polypeptide: 58.4 kD (from nucleotide sequence), 58.4 kD (experimental) [Ishimaru06 ]

Unification Links: Entrez:BAD18963

Relationship Links: Entrez-Nucleotide:PART-OF:AB126085

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 15-May-2008 by Pujar A , Cornell University

Enzymatic reaction of: ferric chelate reductase

EC Number:

2 an Fe(II)-siderophore + NAD+ + H+ <=> 2 an Fe(III)-siderophore + NADH

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the opposite direction.

In Pathways: iron reduction and absorption


Ishimaru06: Ishimaru Y, Suzuki M, Tsukamoto T, Suzuki K, Nakazono M, Kobayashi T, Wada Y, Watanabe S, Matsuhashi S, Takahashi M, Nakanishi H, Mori S, Nishizawa NK (2006). "Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+." Plant J 45(3);335-46. PMID: 16412081

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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