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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Polypeptide: 4-hydroxyacetophenone carboxylase carboxylase subunit

Gene: xccA Accession Number: G-10961 (MetaCyc)

Synonyms: AZOSEA01640, ebA314

Species: Aromatoleum aromaticum EbN1

Component of: 4-hydroxyacetophenone carboxylase (summary available)

Gene Citations: [Wohlbrand08]

Molecular Weight of Polypeptide: 55.095 kD (from nucleotide sequence)

Unification Links: Entrez-gene:3180812 , Protein Model Portal:Q5P8S3 , String:76114.ebA314 , UniProt:Q5P8S3

Relationship Links: InterPro:IN-FAMILY:IPR000891 , InterPro:IN-FAMILY:IPR003379 , InterPro:IN-FAMILY:IPR013785 , Pfam:IN-FAMILY:PF00682 , Pfam:IN-FAMILY:PF02436 , Prosite:IN-FAMILY:PS50991

Gene-Reaction Schematic: ?

Credits:
Created 06-Nov-2008 by Caspi R , SRI International


Subunit of: 4-hydroxyacetophenone carboxylase

Species: Aromatoleum aromaticum EbN1

Subunit composition of 4-hydroxyacetophenone carboxylase = [XccA][XccB][XccC]
         4-hydroxyacetophenone carboxylase carboxylase subunit = XccA
         4-hydroxyacetophenone carboxylase biotin carboxyl carrier subunit = XccB
         4-hydroxyacetophenone carboxylase biotin carboxylase subunit = XccC

Summary:
The enzymes involved in the 1-ethyl-4-hydroxybenzene degradation pathway of Aromatoleum aromaticum EbN1 are encoded in a single large operon ( approximately 15 kb). They include a p-cresol methylhydroxylase-like protein (encoded by pchC and pchF), proposed to be a p-ethylphenol methylhydroxylase, two predicted alcohol dehydrogenases (encoded by chnA and ebA309), a biotin-dependent carboxylase (encoded by xccA, xccB and xccC), an acetoacetyl-CoA synthetase-like protein (acsA) and a thiolase (tioL).

None of these enzymes has been verified biochemically yet. However, expression of these proteins was shown to be upregulated in cells adapted to anaerobic growth with 1-ethyl-4-hydroxybenzene and 4-hydroxyacetophenone [Wohlbrand08].

Credits:
Created 06-Nov-2008 by Caspi R , SRI International


Enzymatic reaction of: 4-hydroxyacetophenone carboxylase

4-hydroxyacetophenone + CO2 + ATP + 2 H2O <=> 4-hydroxybenzoyl-acetate + AMP + 2 phosphate + 3 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: 4-ethylphenol degradation (anaerobic)


References

Wohlbrand08: Wohlbrand L, Wilkes H, Halder T, Rabus R (2008). "Anaerobic degradation of p-ethylphenol by "Aromatoleum aromaticum" strain EbN1: pathway, regulation, and involved proteins." J Bacteriol 190(16);5699-709. PMID: 18539747


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC13B.