MetaCyc Enzyme: S-1-(4-hydroxyphenyl)-ethanol dehydrogenase

Gene: ebA309 Accession Number: G-10969 (MetaCyc)

Synonyms: AZOSEA01610

Species: Aromatoleum aromaticum EbN1

The enzymes involved in the 1-ethyl-4-hydroxybenzene degradation pathway of Aromatoleum aromaticum EbN1 are encoded in a single large operon ( approximately 15 kb). They include a p-cresol methylhydroxylase-like protein (encoded by pchC and pchF), proposed to be a p-ethylphenol methylhydroxylase, two predicted alcohol dehydrogenases (encoded by chnA and ebA309), a biotin-dependent carboxylase (encoded by xccA, xccB and xccC), an acetoacetyl-CoA synthetase-like protein (acsA) and a thiolase (tioL).

None of these enzymes has been verified biochemically yet. However, expression of these proteins was shown to be upregulated in cells adapted to anaerobic growth with 1-ethyl-4-hydroxybenzene and 4-hydroxyacetophenone [Wohlbrand08].

Molecular Weight of Polypeptide: 27.447 kD (from nucleotide sequence)

Unification Links: Entrez-gene:3181788 , Protein Model Portal:Q5P8S6 , String:76114.ebA309 , UniProt:Q5P8S6

Relationship Links: InterPro:IN-FAMILY:IPR002198 , InterPro:IN-FAMILY:IPR002347 , InterPro:IN-FAMILY:IPR016040 , InterPro:IN-FAMILY:IPR020904 , Pfam:IN-FAMILY:PF00106 , Prints:IN-FAMILY:PR00080 , Prints:IN-FAMILY:PR00081 , Prosite:IN-FAMILY:PS00061

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 06-Nov-2008 by Caspi R , SRI International

Enzymatic reaction of: S-1-(4-hydroxyphenyl)-ethanol dehydrogenase

EC Number: 1.1.1.-

S-1-(4-hydroxyphenyl)-ethanol + NAD+ <=> 4-hydroxyacetophenone + NADH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: 4-ethylphenol degradation (anaerobic)


Wohlbrand08: Wohlbrand L, Wilkes H, Halder T, Rabus R (2008). "Anaerobic degradation of p-ethylphenol by "Aromatoleum aromaticum" strain EbN1: pathway, regulation, and involved proteins." J Bacteriol 190(16);5699-709. PMID: 18539747

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, biocyc12.