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June 28th 2015
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June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015

MetaCyc Enzyme: digeranylgeranylglyceryl phosphate synthase

Gene: MTH_1098 Accession Number: G-11079 (MetaCyc)

Synonyms: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase

Species: Methanothermobacter thermautotrophicus Delta H

Digeranylgeranylglyceryl phosphate synthase is an integral membrane enzyme that catalyzes the transfer of a geranylgeranyl unit from geranylgeranyl diphosphate to to the C2 hydroxyl of 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate, forming 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate.

Enzymatic activity has been documented in cell-free extract of Methanothermobacter thermautotrophicus, but the protein has not been purified from that organism [Zhang90]. Orthologous enzymes have been cloned from Sulfolobus solfataricus [Hemmi04] and Methanosarcina acetivorans [Yokoi12] and the enzyme from the former was purified.

Locations: plasma membrane

Molecular Weight of Polypeptide: 30.132 kD (from nucleotide sequence)

Unification Links: Entrez-gene:1471506 , String:187420.MTH1098 , UniProt:O27170

Relationship Links: InterPro:IN-FAMILY:IPR000537 , InterPro:IN-FAMILY:IPR023547 , Pfam:IN-FAMILY:PF01040

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Cellular Component: GO:0005886 - plasma membrane [Zhang90]

Created 23-Feb-2009 by Caspi R , SRI International

Enzymatic reaction of: geranylgeranylglycerol-phosphate geranylgeranyltransferase (digeranylgeranylglyceryl phosphate synthase)

Synonyms: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase

EC Number:

3-(O-geranylgeranyl)-sn-glycerol 1-phosphate + geranylgeranyl diphosphate <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: archaetidylinositol biosynthesis , archaetidylserine and archaetidylethanolamine biosynthesis , Methanobacterium thermoautotrophicum biosynthetic metabolism , CDP-archaeol biosynthesis

Activators (Allosteric): Mg2+


Hemmi04: Hemmi H, Shibuya K, Takahashi Y, Nakayama T, Nishino T (2004). "(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids." J Biol Chem 279(48);50197-203. PMID: 15356000

Yokoi12: Yokoi T, Isobe K, Yoshimura T, Hemmi H (2012). "Archaeal phospholipid biosynthetic pathway reconstructed in Escherichia coli." Archaea 2012;438931. PMID: 22645416

Zhang90: Zhang, D. L., Daniels, L., Poulter, C.D. (1990). "Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction." J. Am. Chem. Soc. 112: 1264-1265.

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jun 30, 2015, biocyc14.