MetaCyc Enzyme: myo-inositol 4-O-methyltransferase

Gene: imt1 Accession Number: G-12581 (MetaCyc)

Species: Mesembryanthemum crystallinum

A myo-inositol O-methyltransferase gene was cloned from the common ice plant, Mesembryanthemum crystallinum. Expression of the gene in leaves was found induced 4-5 times under salt-stress conditions. Assay of the recombinant protein clearly showed that ononitol was the formed product from myo-inositol [Vernon92]. It demonstrated that ononitol but not sequoyitol is the intermediate in pinitol biosynthesis in common ice plant.

Molecular Weight of Polypeptide: 40.0 kD (experimental) [Vernon92 ]

Unification Links: Protein Model Portal:P45986 , SMR:P45986 , UniProt:P45986

Relationship Links: InterPro:IN-FAMILY:IPR001077 , InterPro:IN-FAMILY:IPR011991 , InterPro:IN-FAMILY:IPR012967 , InterPro:IN-FAMILY:IPR016461 , InterPro:IN-FAMILY:IPR029063 , Pfam:IN-FAMILY:PF00891 , Pfam:IN-FAMILY:PF08100 , Prosite:IN-FAMILY:PS51683

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 02-Mar-2011 by Zhang P , TAIR

Enzymatic reaction of: myo-inositol 4-O-methyltransferase

EC Number:

S-adenosyl-L-methionine + myo-inositol <=> S-adenosyl-L-homocysteine + D-ononitol + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: pinitol biosynthesis I


Vernon92: Vernon DM, Bohnert HJ (1992). "A novel methyl transferase induced by osmotic stress in the facultative halophyte Mesembryanthemum crystallinum." EMBO J 11(6);2077-85. PMID: 1600940

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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