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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Enzyme: flavone synthase

Gene: FNS Accession Number: G-12793 (MetaCyc)

Species: Equisetum arvense

Summary:
Enzyme extract from infertile shoots of E. arvense was gel filtered and the fraction was radioactively labeled for flavonoid products. The enzyme fractions were then analyzed on TLC and autoradiography followed by biochemical characterization. The addition of Fe2+, 2 oxolgutarate and ascorbate to the labeled naringenin produced the different flavonoids [Bredebach11] the direct desaturation of naringenin is catalyzed by flavone synthase (FNS) to form apigenin. This is first report of the isolation of FNS from a in a non apiaceae member.

Gene-Reaction Schematic: ?

Credits:
Created 13-Apr-2011 by Pujar A , Boyce Thompson Institute


Enzymatic reaction of: flavone synthase

(2S)-naringenin + 2-oxoglutarate + oxygen <=> apigenin + succinate + CO2 + H2O + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the direction shown.

In Pathways: flavonoid biosynthesis (in equisetum)


References

Bredebach11: Bredebach M, Matern U, Martens S (2011). "Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin." Phytochemistry 72(7);557-63. PMID: 21353683


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC14A.