MetaCyc Enzyme: flavone synthase

Gene: FNS Accession Number: G-12793 (MetaCyc)

Species: Equisetum arvense

Enzyme extract from infertile shoots of E. arvense was gel filtered and the fraction was radioactively labeled for flavonoid products. The enzyme fractions were then analyzed on TLC and autoradiography followed by biochemical characterization. The addition of Fe2+, 2 oxolgutarate and ascorbate to the labeled naringenin produced the different flavonoids [Bredebach11] the direct desaturation of naringenin is catalyzed by flavone synthase (FNS) to form apigenin. This is first report of the isolation of FNS from a in a non apiaceae member.

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 13-Apr-2011 by Pujar A , Boyce Thompson Institute

Enzymatic reaction of: flavone synthase

(2S)-naringenin + 2-oxoglutarate + oxygen <=> apigenin + succinate + CO2 + H2O + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: flavonoid biosynthesis (in equisetum)


Bredebach11: Bredebach M, Matern U, Martens S (2011). "Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin." Phytochemistry 72(7);557-63. PMID: 21353683

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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