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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
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MetaCyc Enzyme: C18-Δ9 elongase

Gene: ASE1 Accession Number: G-14792 (MetaCyc)

Species: Isochrysis galbana

Summary:
The microalga Isochrysis galbana is rich in long chain polyunsaturated fatty acids such as (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate [Qi02]. The ASE1 gene, encoding a polyunsaturated fatty acid-elongating activity, was isolated from this organism [Qi02]. Transgenic Saccharomyces cerevisiae expressing ASE1 specifically elongated the C18-Δ9 PUFAs linoleate and α-linolenate to eicosadienoate and eicosatrienoate, respectively. This suggests that ASE1 encodes the 3-oxoacyl-CoA synthase component of the elongase, and that it is able to interact with the other members of the yeast elongase complex (see very long chain fatty acid biosynthesis II) [Qi02].

Molecular Weight of Polypeptide: 30.19 kD (from nucleotide sequence)

Unification Links: Entrez-Nucleotide:AF390174 , UniProt:Q8W213

Relationship Links: InterPro:IN-FAMILY:IPR002076 , Panther:IN-FAMILY:PTHR11157 , Pfam:IN-FAMILY:PF01151

Gene-Reaction Schematic: ?

Credits:
Created 28-Oct-2011 by Weerasinghe D , SRI International


Enzymatic reaction of: Δ9-elongase (C18-Δ9 elongase)

α-linolenoyl-CoA + malonyl-CoA + H+ <=> 3-oxo-eicosatrienoyl-CoA + CO2 + coenzyme A

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: docosahexanoate biosynthesis II


Enzymatic reaction of: Δ9 elongase

α-linolenate + malonyl-CoA + 5 H+ <=> eicosatrienoate + CO2 + coenzyme A + H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.


References

Qi02: Qi B, Beaudoin F, Fraser T, Stobart AK, Napier JA, Lazarus CM (2002). "Identification of a cDNA encoding a novel C18-Delta(9) polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana." FEBS Lett 510(3);159-65. PMID: 11801246


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 25, 2014, BIOCYC13A.