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MetaCyc Polypeptide: phenolphthiocerol synthesis polyketide synthase type I

Gene: pks15/1 Accession Number: G-15015 (MetaCyc)

Species: Mycobacterium bovis

Summary:
Phenolphthiocerol is a crucial virulence factor of pathogenic mycobacteria. There is an accumulation of glycosylated p-hydroxybenzoic acid methyl esters and a deficiency in the production of phenolphthiocerol in mycobacterial strains mutant for pks15/1 which codes for phenolphthiocerol synthesis polyketide synthase type I [Constant02]. It catalyzes the elongation of p-hydroxybenzoic acid to form p-hydroxyphenylalkanoate intermediates in the phenolphthiocerol biosynthetic pathway which has yet to be fully elucidated.

Molecular Weight of Polypeptide: 218.3 kD (from nucleotide sequence)

Unification Links: Protein Model Portal:Q7TXK8 , SMR:Q7TXK8 , String:233413.Mb2971c , UniProt:Q7TXK8

Relationship Links: InterPro:IN-FAMILY:IPR001227 , InterPro:IN-FAMILY:IPR006162 , InterPro:IN-FAMILY:IPR009081 , InterPro:IN-FAMILY:IPR011032 , InterPro:IN-FAMILY:IPR013149 , InterPro:IN-FAMILY:IPR013154 , InterPro:IN-FAMILY:IPR013968 , InterPro:IN-FAMILY:IPR014030 , InterPro:IN-FAMILY:IPR014031 , InterPro:IN-FAMILY:IPR014043 , InterPro:IN-FAMILY:IPR015083 , InterPro:IN-FAMILY:IPR016035 , InterPro:IN-FAMILY:IPR016036 , InterPro:IN-FAMILY:IPR016038 , InterPro:IN-FAMILY:IPR016039 , InterPro:IN-FAMILY:IPR016040 , InterPro:IN-FAMILY:IPR018201 , InterPro:IN-FAMILY:IPR020801 , InterPro:IN-FAMILY:IPR020806 , InterPro:IN-FAMILY:IPR020807 , InterPro:IN-FAMILY:IPR020841 , InterPro:IN-FAMILY:IPR020842 , InterPro:IN-FAMILY:IPR020843 , Panther:IN-FAMILY:PTHR11712 , Pfam:IN-FAMILY:PF00107 , Pfam:IN-FAMILY:PF00109 , Pfam:IN-FAMILY:PF00550 , Pfam:IN-FAMILY:PF00698 , Pfam:IN-FAMILY:PF02801 , Pfam:IN-FAMILY:PF08240 , Pfam:IN-FAMILY:PF08659 , Pfam:IN-FAMILY:PF08990 , Prosite:IN-FAMILY:PS00012 , Prosite:IN-FAMILY:PS00606 , Prosite:IN-FAMILY:PS50075 , Smart:IN-FAMILY:SM00822 , Smart:IN-FAMILY:SM00823 , Smart:IN-FAMILY:SM00825 , Smart:IN-FAMILY:SM00826 , Smart:IN-FAMILY:SM00827 , Smart:IN-FAMILY:SM00829

Credits:
Created 07-Mar-2012 by Weerasinghe D , SRI International


References

Constant02: Constant P, Perez E, Malaga W, Laneelle MA, Saurel O, Daffe M, Guilhot C (2002). "Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene." J Biol Chem 277(41);38148-58. PMID: 12138124


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13A.