MetaCyc Enzyme: carboxyspermidine dehydrogenase

Gene: C8J_0166 Accession Number: G-15130 (MetaCyc)

Species: Campylobacter jejuni jejuni 81116

The subunit structure of this enzyme has not been reported.

This enzyme catalyzes the penultimate step in spermidine biosynthesis in Campylobacter jejuni (see pathway spermidine biosynthesis II).

A gene deletion mutant did not abolish spermidine biosynthesis. Instead, it resulted in a large accumulation of spermidine. It was suggested that a metabolic bypass was operative and that this dehydrogenase is a rate-limiting enzyme that regulates spermidine levels [Hanfrey11].

Map Position: [175,622 <- 176,827]

Molecular Weight of Polypeptide: 44.848 kD (from nucleotide sequence)

Unification Links: Entrez-gene:5617902 , Protein Model Portal:A8FJX8 , String:407148.C8J_0166 , UniProt:A8FJX8

Relationship Links: InterPro:IN-FAMILY:IPR005097 , InterPro:IN-FAMILY:IPR016040 , Pfam:IN-FAMILY:PF03435

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 19-Apr-2012 by Fulcher CA , SRI International

Enzymatic reaction of: carboxyspermidine dehydrogenase

carboxyspermidine + NADP+ + H2O <=> L-aspartate-semialdehyde + putrescine + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the opposite direction.

In Pathways: spermidine biosynthesis II


Hanfrey11: Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ (2011). "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota." J Biol Chem 286(50);43301-12. PMID: 22025614

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, biocyc13.