Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Enzyme: cellulose synthase

Gene: CesA1 Accession Number: G-1681 (MetaCyc)

Synonyms: At4g32410, rsw1, β-1,4-glucan synthase

Species: Arabidopsis thaliana col

Summary:
Cellulose, the most abundant polysaccharide on earth, determines the orientation of cell expansion and provides supporting material for plant cells [Pauly08]. The cellulose-formed microfibrils, consisting of a linear chain of several hundred to over 10,000 β-1, 4-linked glucan, are synthesized by a plasma membrane-localized cellulose synthase complex (CSC). In vascular plants, multiple cellulose synthase catalytic subunits are required for cellulose synthesis [Taylor03a]. The complex extrudes up to 36 individual cellulose chains that are bound together to form the cellulose microfibril [Wightman10]. Transgenic plants expressing antisense cellulose synthase constructs have reduced cellulose content.

Citations: [Burn02]

Unification Links: DIP:DIP-59354N , PhylomeDB:O48946 , Pride:O48946 , Protein Model Portal:O48946 , SMR:O48946 , String:O48946 , TAIR:AT4G32410 , UniProt:O48946

Relationship Links: CAZy:IN-FAMILY:GT2 , InterPro:IN-FAMILY:IPR001841 , InterPro:IN-FAMILY:IPR005150 , InterPro:IN-FAMILY:IPR013083 , InterPro:IN-FAMILY:IPR027934 , Pfam:IN-FAMILY:PF03552 , Pfam:IN-FAMILY:PF14569 , Prosite:IN-FAMILY:PS00518 , Prosite:IN-FAMILY:PS50089 , Smart:IN-FAMILY:SM00184

Gene-Reaction Schematic: ?

Credits:
Revised 30-Sep-2011 by Weerasinghe D


Enzymatic reaction of: UDP-glucose:1,4-β-D-glucan 4-β-D-glucosyltransferase (cellulose synthase)

EC Number: 2.4.1.12

UDP-α-D-glucose + cellulose(n) <=> cellulose(n+1) + UDP

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Reversibility of this reaction is unspecified.

In Pathways: cellulose biosynthesis


References

Burn02: Burn JE, Hocart CH, Birch RJ, Cork AC, Williamson RE (2002). "Functional analysis of the cellulose synthase genes CesA1, CesA2, and CesA3 in Arabidopsis." Plant Physiol 129(2);797-807. PMID: 12068120

Pauly08: Pauly M, Keegstra K (2008). "Cell-wall carbohydrates and their modification as a resource for biofuels." Plant J 54(4);559-68. PMID: 18476863

Taylor03a: Taylor NG, Howells RM, Huttly AK, Vickers K, Turner SR (2003). "Interactions among three distinct CesA proteins essential for cellulose synthesis." Proc Natl Acad Sci U S A 100(3);1450-5. PMID: 12538856

Wightman10: Wightman R, Turner S (2010). "Trafficking of the cellulose synthase complex in developing xylem vessels." Biochem Soc Trans 38(3);755-60. PMID: 20491661


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc11.