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discounted EARLY registration ends Dec 31, 2014
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
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discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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MetaCyc Enzyme: cellulose synthase

Gene: CesA1 Accession Number: G-1681 (MetaCyc)

Synonyms: At4g32410, rsw1, β-1,4-glucan synthase

Species: Arabidopsis thaliana col

Summary:
Cellulose, the most abundant polysaccharide on earth, determines the orientation of cell expansion and provides supporting material for plant cells [Pauly08]. The cellulose-formed microfibrils, consisting of a linear chain of several hundred to over 10,000 β-1, 4-linked glucan, are synthesized by a plasma membrane-localized cellulose synthase complex (CSC). In vascular plants, multiple cellulose synthase catalytic subunits are required for cellulose synthesis [Taylor03]. The complex extrudes up to 36 individual cellulose chains that are bound together to form the cellulose microfibril [Wightman10]. Transgenic plants expressing antisense cellulose synthase constructs have reduced cellulose content.

Citations: [Burn02]

Unification Links: DIP:DIP-59354N , PhylomeDB:O48946 , Pride:O48946 , Protein Model Portal:O48946 , SMR:O48946 , String:O48946 , TAIR:AT4G32410 , UniProt:O48946

Relationship Links: CAZy:IN-FAMILY:GT2 , InterPro:IN-FAMILY:IPR001841 , InterPro:IN-FAMILY:IPR005150 , InterPro:IN-FAMILY:IPR013083 , InterPro:IN-FAMILY:IPR027934 , Pfam:IN-FAMILY:PF03552 , Pfam:IN-FAMILY:PF14569 , Prosite:IN-FAMILY:PS00518 , Prosite:IN-FAMILY:PS50089 , Smart:IN-FAMILY:SM00184

Gene-Reaction Schematic: ?

Credits:
Revised 30-Sep-2011 by Weerasinghe D


Enzymatic reaction of: UDP-glucose:1,4-β-D-glucan 4-β-D-glucosyltransferase (cellulose synthase)

EC Number: 2.4.1.12

UDP-α-D-glucose + cellulose(n) <=> cellulose(n+1) + UDP

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Reversibility of this reaction is unspecified.

In Pathways: cellulose biosynthesis


References

Burn02: Burn JE, Hocart CH, Birch RJ, Cork AC, Williamson RE (2002). "Functional analysis of the cellulose synthase genes CesA1, CesA2, and CesA3 in Arabidopsis." Plant Physiol 129(2);797-807. PMID: 12068120

Pauly08: Pauly M, Keegstra K (2008). "Cell-wall carbohydrates and their modification as a resource for biofuels." Plant J 54(4);559-68. PMID: 18476863

Taylor03: Taylor NG, Howells RM, Huttly AK, Vickers K, Turner SR (2003). "Interactions among three distinct CesA proteins essential for cellulose synthesis." Proc Natl Acad Sci U S A 100(3);1450-5. PMID: 12538856

Wightman10: Wightman R, Turner S (2010). "Trafficking of the cellulose synthase complex in developing xylem vessels." Biochem Soc Trans 38(3);755-60. PMID: 20491661


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc12.