Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: indole-3-glycerol phosphate synthase

Gene: trpC Accession Number: G-2641 (MetaCyc)

Synonyms: InGPS

Species: Thermococcus kodakarensis

Molecular Weight of Polypeptide: 27 kD (experimental) [Tang99 ]

Unification Links: ModBase:Q9YGB5 , Protein Model Portal:Q9YGB5 , String:69014.TK0252 , Swiss-Model:Q9YGB5 , UniProt:Q9YGB5

Relationship Links: InterPro:IN-FAMILY:IPR001468 , InterPro:IN-FAMILY:IPR011060 , InterPro:IN-FAMILY:IPR013785 , InterPro:IN-FAMILY:IPR013798 , Pfam:IN-FAMILY:PF00218 , Prosite:IN-FAMILY:PS00614

Gene-Reaction Schematic: ?

MultiFun Terms: metabolism biosynthesis of building blocks amino acids tryptophan


Enzymatic reaction of: indole-3-glycerol phosphate synthase

EC Number: 4.1.1.48

1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + H+ <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: tryptophan biosynthesis

T(opt): 85 °C [Tang99]

pH(opt): 5.5 [Tang99]


References

Tang99: Tang X, Ezaki S, Fujiwara S, Takagi M, Atomi H, Imanaka T (1999). "The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA." Mol Gen Genet 262(4-5);815-21. PMID: 10628865


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13B.