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MetaCyc Enzyme: indole-3-glycerol phosphate synthase

Gene: trpC Accession Number: G-2641 (MetaCyc)

Synonyms: InGPS

Species: Thermococcus kodakarensis

Molecular Weight of Polypeptide: 27 kD (experimental) [Tang99 ]

Unification Links: ModBase:Q9YGB5 , Protein Model Portal:Q9YGB5 , String:69014.TK0252 , Swiss-Model:Q9YGB5 , UniProt:Q9YGB5

Relationship Links: InterPro:IN-FAMILY:IPR001468 , InterPro:IN-FAMILY:IPR011060 , InterPro:IN-FAMILY:IPR013785 , InterPro:IN-FAMILY:IPR013798 , Pfam:IN-FAMILY:PF00218 , Prosite:IN-FAMILY:PS00614

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

MultiFun Terms: metabolism biosynthesis of building blocks amino acids tryptophan


Enzymatic reaction of: indole-3-glycerol phosphate synthase

EC Number: 4.1.1.48

1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + H+ <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: L-tryptophan biosynthesis

T(opt): 85 °C [Tang99]

pH(opt): 5.5 [Tang99]


References

Tang99: Tang X, Ezaki S, Fujiwara S, Takagi M, Atomi H, Imanaka T (1999). "The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA." Mol Gen Genet 262(4-5);815-21. PMID: 10628865


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Apr 20, 2015, biocyc12.