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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Enzyme: methionine adenosyltransferase 2

Gene: sam2 Accession Number: G-467 (MetaCyc)

Synonyms: S-adenosylmethionine synthetase 2, AdoMet synthase 2

Species: Saccharomyces cerevisiae

Subunit composition of methionine adenosyltransferase 2 = [Sam2]4

Summary:
The subunit composition is not entirely clear. There are conflicting data. It is known that the subunit structure is tetrameric. The structure is represented here as homotetrameric for simplicity. [Thomas97]

Molecular Weight of Polypeptide: 42.124 kD (from nucleotide sequence) [Bairoch93a ]

Unification Links: DIP:DIP-4001N , Mint:MINT-476096 , ModBase:P19358 , Pride:P19358 , Protein Model Portal:P19358 , SMR:P19358 , String:4932.YDR502C , Swiss-Model:P19358 , UniProt:P19358

Relationship Links: InterPro:IN-FAMILY:IPR002133 , InterPro:IN-FAMILY:IPR022628 , InterPro:IN-FAMILY:IPR022629 , InterPro:IN-FAMILY:IPR022630 , InterPro:IN-FAMILY:IPR022631 , InterPro:IN-FAMILY:IPR022636 , Panther:IN-FAMILY:PTHR11964 , Pfam:IN-FAMILY:PF00438 , Pfam:IN-FAMILY:PF02772 , Pfam:IN-FAMILY:PF02773 , Prosite:IN-FAMILY:PS00376 , Prosite:IN-FAMILY:PS00377

Gene-Reaction Schematic: ?


Enzymatic reaction of: methionine adenosyltransferase

Synonyms: AdoMet synthase, methionine adenosyltransferase

EC Number: 2.5.1.6

ATP + L-methionine + H2O <=> S-adenosyl-L-methionine + phosphate + diphosphate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is irreversible in the direction shown.

In Pathways: methionine degradation I (to homocysteine) , S-adenosyl-L-methionine biosynthesis

Summary:
S-Adenosylmethionine synthetase 2 is one of two S. cerevisiae enzymes that catalyzes the formation of S-adenosylmethionine. Each enzyme is active independently. [Thomas97, Thomas88, Thomas91]


References

Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Thomas88: Thomas D, Rothstein R, Rosenberg N, Surdin-Kerjan Y (1988). "SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes." Mol Cell Biol 1988;8(12);5132-9. PMID: 3072475

Thomas91: Thomas D, Surdin-Kerjan Y (1991). "The synthesis of the two S-adenosyl-methionine synthetases is differently regulated in Saccharomyces cerevisiae." Mol Gen Genet 1991;226(1-2);224-32. PMID: 1903502

Thomas97: Thomas D, Surdin-Kerjan Y (1997). "Metabolism of sulfur amino acids in Saccharomyces cerevisiae." Microbiol Mol Biol Rev 61(4);503-32. PMID: 9409150


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc13.