|Gene:||sam2||Accession Number: G-467 (MetaCyc)|
Synonyms: S-adenosylmethionine synthetase 2, AdoMet synthase 2
Species: Saccharomyces cerevisiae
Subunit composition of methionine adenosyltransferase 2 = [Sam2]4
The subunit composition is not entirely clear. There are conflicting data. It is known that the subunit structure is tetrameric. The structure is represented here as homotetrameric for simplicity. [Thomas97]
Molecular Weight of Polypeptide: 42.124 kD (from nucleotide sequence) [Bairoch93a ]
Relationship Links: InterPro:IN-FAMILY:IPR002133 , InterPro:IN-FAMILY:IPR022628 , InterPro:IN-FAMILY:IPR022629 , InterPro:IN-FAMILY:IPR022630 , InterPro:IN-FAMILY:IPR022631 , InterPro:IN-FAMILY:IPR022636 , Panther:IN-FAMILY:PTHR11964 , Pfam:IN-FAMILY:PF00438 , Pfam:IN-FAMILY:PF02772 , Pfam:IN-FAMILY:PF02773 , Prosite:IN-FAMILY:PS00376 , Prosite:IN-FAMILY:PS00377
Enzymatic reaction of: methionine adenosyltransferase
Synonyms: AdoMet synthase, methionine adenosyltransferase
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.
The reaction is irreversible in the direction shown.
S-Adenosylmethionine synthetase 2 is one of two S. cerevisiae enzymes that catalyzes the formation of S-adenosylmethionine. Each enzyme is active independently. [Thomas97, Thomas88, Thomas91]
Thomas88: Thomas D, Rothstein R, Rosenberg N, Surdin-Kerjan Y (1988). "SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes." Mol Cell Biol 1988;8(12);5132-9. PMID: 3072475
Thomas91: Thomas D, Surdin-Kerjan Y (1991). "The synthesis of the two S-adenosyl-methionine synthetases is differently regulated in Saccharomyces cerevisiae." Mol Gen Genet 1991;226(1-2);224-32. PMID: 1903502
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