MetaCyc Enzyme: tetrahydrodipicolinate acetyltransferase

Gene: ykuQ Accession Number: G-5082 (MetaCyc)

Species: Bacillus subtilis

Even though the enzymatic activity of tetrahydrodipicolinate acetyltransferase has been shown experimentally in some Gram-positive bacilli [Sundharadas67], the enzyme has not been purifed. The gene encoding it has been located in the B. subtilis genome by sequence similarity, and by its inclusion in a long LYS-element-regulated lysine biosynthesis operon [Rodionov03].

Unification Links: Entrez-gene:939193

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

MultiFun Terms: metabolism biosynthesis of building blocks amino acids lysine
metabolism biosynthesis of macromolecules (cellular constituents)

Enzymatic reaction of: tetrahydrodipicolinate acetyltransferase

EC Number:

acetyl-CoA + (S)-2,3,4,5-tetrahydrodipicolinate + H2O <=> L-2-acetamido-6-oxoheptanedioate + coenzyme A

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: L-lysine biosynthesis II


Rodionov03: Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS (2003). "Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?." Nucleic Acids Res 31(23);6748-57. PMID: 14627808

Sundharadas67: Sundharadas G, Gilvarg C (1967). "Biosynthesis of alpha,epsilon-diaminopimelic acid in Bacillus megaterium." J Biol Chem 242(17);3983-4. PMID: 4962540

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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