Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: acetyl-diaminopimelate aminotransferase

Gene: patA Accession Number: G-5083 (MetaCyc)

Species: Bacillus subtilis

Summary:
Even though the enzymatic activity of acetyl-diaminopimelate aminotransferase has been shown experimentally in some Gram-positive bacilli [Sundharadas67], the enzyme has not been purifed. The gene encoding it has been located in the B. subtilis genome by sequence similarity, and by its inclusion in a long LYS-element-regulated lysine biosynthesis operon [Rodionov03].

Unification Links: Entrez-gene:939235

Relationship Links: Entrez-Nucleotide:RELATED-TO:AJ222587

Gene-Reaction Schematic: ?

MultiFun Terms: metabolism biosynthesis of building blocks amino acids lysine
metabolism biosynthesis of macromolecules (cellular constituents)


Enzymatic reaction of: acetyl-diaminopimelate aminotransferase

L-2-acetamido-6-oxoheptanedioate + L-glutamate <=> N-acetyl-L,L-2,6-diaminopimelate + 2-oxoglutarate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: lysine biosynthesis II


References

Rodionov03: Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS (2003). "Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?." Nucleic Acids Res 31(23);6748-57. PMID: 14627808

Sundharadas67: Sundharadas G, Gilvarg C (1967). "Biosynthesis of alpha,epsilon-diaminopimelic acid in Bacillus megaterium." J Biol Chem 242(17);3983-4. PMID: 4962540


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, BIOCYC13A.