|Gene:||ALG7||Accession Number: G-5522 (MetaCyc)|
Synonyms: TUR1, UDP-N-acetylglucosamine: dolichyl phosphate, N-acetylglucosamine-1-phosphate transferase, UDP-N-acetylglucosamine-1-P transferase, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase, N-acetyl glucosaminyl phosphate transferase
Species: Saccharomyces cerevisiae
The enzyme contains a 13-amino acid consensus sequence thought to be involved in dolichol recognition. This sequence is also found in the glycosyltransferase products of genes ALG1 and DPM1, and the product of gene SEC59 [Albright89].
The ALG7 gene is essential for cell growth [Kukuruzinska87]
Gene Citations: [Barnes84]
Locations: endoplasmic reticulum
|Map Position: [705,442 <- 706,788]|
|Cellular Component:||GO:0005783 - endoplasmic reticulum [Marriott79]|
Enzymatic reaction of: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglocosaminephosphotransferase
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
The reaction is favored in the direction shown.
In Pathways: protein N-glycosylation (eukaryotic, high mannose)
Tunicamycin is a specific inhibitor of this enzyme in the pathway [Rine83].
pH(opt): 7.5 [Sharma82]
Albright89: Albright CF, Orlean P, Robbins PW (1989). "A 13-amino acid peptide in three yeast glycosyltransferases may be involved in dolichol recognition." Proc Natl Acad Sci U S A 86(19);7366-9. PMID: 2678101
Marriott79: Marriott M, Tanner W (1979). "Localization of dolichyl phosphate- and pyrophosphate-dependent glycosyl transfer reactions in Saccharomyces cerevisiae." J Bacteriol 139(2);566-72. PMID: 222737
Sato01: Sato M, Fujisaki S, Sato K, Nishimura Y, Nakano A (2001). "Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis." Genes Cells 6(6);495-506. PMID: 11442630
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