MetaCyc Enzyme: L-serine dehydratase

Gene: sdaA Accession Number: G-6543 (MetaCyc)

Species: Corynebacterium sp.

The sdaA gene of Corynebacterium glutamicum, encoding an L-serine dehydratase (L-SerDH), was identified by sequence homology search, using the Escherichia coli sdaA, sdaB and tdcG sequences. The gene was cloned into a plasmid, and transformed back into C. glutamicum. The overexpressing strain demonstrated high activity of L-serDH, and was able to grow with L-serine as a single substrate, confirming the identity of the gene [Netzer04].

Unification Links: Entrez-gene:3343561 , ModBase:Q8NQ09 , Protein Model Portal:Q8NQ09 , String:196627.cg1852 , Swiss-Model:Q8NQ09 , UniProt:Q8NQ09

Relationship Links: InterPro:IN-FAMILY:IPR004644 , InterPro:IN-FAMILY:IPR005130 , InterPro:IN-FAMILY:IPR005131 , InterPro:IN-FAMILY:IPR029009 , Pfam:IN-FAMILY:PF03313 , Pfam:IN-FAMILY:PF03315

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

MultiFun Terms: metabolism degradation of macromolecules proteins/peptides/glycopeptides

Enzymatic reaction of: L-serine dehydratase

L-serine <=> 2-aminoprop-2-enoate + H+ + H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: glycine betaine degradation I


Netzer04: Netzer R, Peters-Wendisch P, Eggeling L, Sahm H (2004). "Cometabolism of a nongrowth substrate: L-serine utilization by Corynebacterium glutamicum." Appl Environ Microbiol 70(12);7148-55. PMID: 15574911

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Jul 31, 2015, biocyc11.