MetaCyc Enzyme: uroporphyrinogen decarboxylase

Gene: hemE Accession Number: G-9033 (MetaCyc)

Species: Rhodobacter sphaeroides

The molecular weight was determined by SDS-PAGE. The native molecular weight was 39 kD by gel filtration chromatography [Jones93].

Map Position: [2,424,282 -> 2,425,313]

Molecular Weight of Polypeptide: 41 kD (experimental) [Jones93 ]

pI: 4.4 [Jones93]

Unification Links: Entrez-gene:3718330 , Entrez:ABA79856

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Enzymatic reaction of: uroporphyrinogen decarboxylase

EC Number:

uroporphyrinogen-III + 4 H+ <=> coproporphyrinogen III + 4 CO2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: superpathway of heme biosynthesis from glycine , superpathway of bacteriochlorophyll a biosynthesis , heme biosynthesis I (aerobic) , chlorophyllide a biosynthesis II (anaerobic)

The enzyme was subject to substrate inhibition [Jones93].

Inhibitors (Unknown Mechanism): porphobilinogen [Jones93] , uroporphyrin I [Jones93] , uroporphyrin III [Jones93] , coproporphyrin I [Jones93] , coproporphyrin III [Jones93] , haematoporphyrin IX [Jones93] , iodoacetamide [Jones93] , N-ethylmaleimide [Jones93] , phenylglyoxal [Jones93] , Hg2+ [Jones93] , Cu2+ [Jones93]

Kinetic Parameters:

Km (μM)

pH(opt): 6.7-6.9 [Jones93]


Jones93: Jones RM, Jordan PM (1993). "Purification and properties of the uroporphyrinogen decarboxylase from Rhodobacter sphaeroides." Biochem J 293 ( Pt 3);703-12. PMID: 8352737

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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