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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Protein: citrate lyase, citrate-ACP transferase component

Gene: citF Accession Numbers: G6341 (MetaCyc), b0615, ECK0608

Synonyms: ybdV

Species: Escherichia coli K-12 substr. MG1655

Component of: citrate lyase, inactive

Subunit composition of citrate lyase, citrate-ACP transferase component = [CitF]6
         citrate lyase, citrate-ACP transferase α subunit = CitF

Alternative forms of citrate lyase, inactive: citrate lyase (extended summary available)

Locations: cytosol

Map Position: [647,262 <- 648,794]

Molecular Weight of Polypeptide: 55.173 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0002119 , EchoBASE:EB3311 , EcoGene:EG13541 , EcoliWiki:b0615 , ModBase:P75726 , OU-Microarray:b0615 , PortEco:citF , Pride:P75726 , Protein Model Portal:P75726 , RefSeq:NP_415148 , RegulonDB:G6341 , SMR:P75726 , String:511145.b0615 , Swiss-Model:P75726 , UniProt:P75726

Relationship Links: InterPro:IN-FAMILY:IPR006472 , Pfam:IN-FAMILY:PF04223

Gene-Reaction Schematic: ?

GO Terms:

Biological Process: GO:0006084 - acetyl-CoA metabolic process Inferred by computational analysis [GOA01]
Molecular Function: GO:0008814 - citrate CoA-transferase activity Inferred by computational analysis [GOA01a, GOA01]
GO:0008815 - citrate (pro-3S)-lyase activity Inferred by computational analysis [GOA01a]
GO:0016740 - transferase activity Inferred by computational analysis [UniProtGOA11a]
GO:0016829 - lyase activity Inferred by computational analysis [UniProtGOA11a]
Cellular Component: GO:0005737 - cytoplasm Inferred by computational analysis [UniProtGOA11, UniProtGOA11a]
GO:0005829 - cytosol Inferred by computational analysis [DiazMejia09]
GO:0009346 - citrate lyase complex Inferred by computational analysis [GOA01]

MultiFun Terms: metabolism central intermediary metabolism unassigned reversible reactions

Credits:
Imported from EcoCyc 16-Sep-2014 by Paley S , SRI International


Subunit of: citrate lyase, inactive

Synonyms: (HS)-citrate lyase, citrate lyase, thiol form, deacetyl-citrate lyase

Species: Escherichia coli K-12 substr. MG1655

Subunit composition of citrate lyase, inactive = [(CitD)6][(CitF)6][(CitE)6]
         citrate lyase [acyl carrier protein] component = (CitD)6 (summary available)
                 citrate lyase, acyl carrier γ subunit = CitD
         citrate lyase, citrate-ACP transferase component = (CitF)6
                 citrate lyase, citrate-ACP transferase α subunit = CitF
         citrate lyase, citryl-ACP lyase component = (CitE)6
                 citrate lyase, citryl-ACP lyase β subunit = CitE

Reactions known to consume the compound:

citrate lyase activation :
[a holo citrate lyase acyl-carrier protein] + S-acetyl phosphopantetheine → an acetyl-[holo citrate lyase acyl-carrier protein] + 4'-phosphopantetheine
[a holo citrate lyase acyl-carrier protein] + acetate + ATP → an acetyl-[holo citrate lyase acyl-carrier protein] + AMP + diphosphate

Reactions known to produce the compound:

citrate lyase activation :
an acetyl-[holo citrate lyase acyl-carrier protein] + 6 H2O → [a holo citrate lyase acyl-carrier protein] + 6 acetate
2'-(5''-triphospho-α-D-ribosyl)-3'-dephospho-CoA + [an apo citrate-lyase acyl-carrier protein] → [a holo citrate lyase acyl-carrier protein] + diphosphate

Credits:
Imported from EcoCyc 16-Sep-2014 by Paley S , SRI International

History:
Markus Krummenacker on Tue Oct 14, 1997:
Gene object created from Blattner lab Genbank (v. M52) entry.


References

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

GOA01: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

GOA01a: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

UniProtGOA11: UniProt-GOA (2011). "Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries."

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc14.