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MetaCyc Protein: citrate lyase, citrate-ACP transferase component

Gene: citF Accession Numbers: G6341 (MetaCyc), b0615, ECK0608

Synonyms: ybdV

Species: Escherichia coli K-12 substr. MG1655

Component of: citrate lyase, inactive

Subunit composition of citrate lyase, citrate-ACP transferase component = [CitF]6
         citrate lyase, citrate-ACP transferase α subunit = CitF

Alternative forms of citrate lyase, inactive: citrate lyase (extended summary available)

Locations: cytosol

Map Position: [647,262 <- 648,794]

Molecular Weight of Polypeptide: 55.173 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0002119 , EchoBASE:EB3311 , EcoGene:EG13541 , EcoliWiki:b0615 , ModBase:P75726 , OU-Microarray:b0615 , PortEco:citF , Pride:P75726 , Protein Model Portal:P75726 , RefSeq:NP_415148 , RegulonDB:G6341 , SMR:P75726 , String:511145.b0615 , Swiss-Model:P75726 , UniProt:P75726

Relationship Links: InterPro:IN-FAMILY:IPR006472 , Pfam:IN-FAMILY:PF04223

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Biological Process: GO:0006084 - acetyl-CoA metabolic process Inferred by computational analysis [GOA01]
Molecular Function: GO:0008814 - citrate CoA-transferase activity Inferred by computational analysis [GOA01a, GOA01]
GO:0008815 - citrate (pro-3S)-lyase activity Inferred by computational analysis [GOA01a]
GO:0016740 - transferase activity Inferred by computational analysis [UniProtGOA11]
GO:0016829 - lyase activity Inferred by computational analysis [UniProtGOA11]
Cellular Component: GO:0005737 - cytoplasm Inferred by computational analysis [UniProtGOA11a, UniProtGOA11]
GO:0005829 - cytosol Inferred by computational analysis [DiazMejia09]
GO:0009346 - citrate lyase complex Inferred by computational analysis [GOA01]

MultiFun Terms: metabolism central intermediary metabolism unassigned reversible reactions

Credits:
Imported from EcoCyc 27-Jan-2015 by Paley S , SRI International


Subunit of: citrate lyase, inactive

Synonyms: (HS)-citrate lyase, citrate lyase, thiol form, deacetyl-citrate lyase

Species: Escherichia coli K-12 substr. MG1655

Subunit composition of citrate lyase, inactive = [(CitD)6][(CitF)6][(CitE)6]
         citrate lyase [acyl carrier protein] component = (CitD)6 (summary available)
                 citrate lyase, acyl carrier γ subunit = CitD
         citrate lyase, citrate-ACP transferase component = (CitF)6
                 citrate lyase, citrate-ACP transferase α subunit = CitF
         citrate lyase, citryl-ACP lyase component = (CitE)6
                 citrate lyase, citryl-ACP lyase β subunit = CitE

Reactions known to consume the compound:

citrate lyase activation :
[a holo citrate lyase acyl-carrier protein] + acetate + ATP → an acetyl-[holo citrate lyase acyl-carrier protein] + AMP + diphosphate
[a holo citrate lyase acyl-carrier protein] + S-acetyl phosphopantetheine → an acetyl-[holo citrate lyase acyl-carrier protein] + 4'-phosphopantetheine

Reactions known to produce the compound:

citrate lyase activation :
an acetyl-[holo citrate lyase acyl-carrier protein] + H2O → [a holo citrate lyase acyl-carrier protein] + acetate + H+
2'-(5''-triphospho-α-D-ribosyl)-3'-dephospho-CoA + [a citrate-lyase acyl-carrier protein] → [a holo citrate lyase acyl-carrier protein] + diphosphate + H+

Credits:
Imported from EcoCyc 27-Jan-2015 by Paley S , SRI International

History:
Markus Krummenacker on Tue Oct 14, 1997:
Gene object created from Blattner lab Genbank (v. M52) entry.


References

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

GOA01: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

GOA01a: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

UniProtGOA11: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Apr 26, 2015, biocyc14.