|Gene:||MMP14||Accession Number: HS08195 (MetaCyc)|
Synonyms: MT1-MMP, MTMMP1, MMP-X1, membrane-type matrix metalloproteinase 1, membrane-type-1 matrix metalloproteinase, MMP-14, MT-MMP 1, MT1MMP
Species: Homo sapiens
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases, but some are membrane bound. The membrane-bound MMPs contain a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
MMP14 is a member of the membrane-type MMP (MT-MMP) subfamily. This protein activates progelatinase (MMP2), and may trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface [Segarra07].
It was reported that MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases [Liu10c].
|Map Position: [17,093,094 -> 17,104,104]|
Unification Links: ArrayExpress:P50281 , DIP:DIP-35111N , Entrez-gene:4323 , Mint:MINT-246780 , PhosphoSite:P50281 , Pride:P50281 , Protein Model Portal:P50281 , SMR:P50281 , String:9606.ENSP00000308208 , UniProt:P50281
Relationship Links: InterPro:IN-FAMILY:IPR000585 , InterPro:IN-FAMILY:IPR001818 , InterPro:IN-FAMILY:IPR002477 , InterPro:IN-FAMILY:IPR006026 , InterPro:IN-FAMILY:IPR016293 , InterPro:IN-FAMILY:IPR018486 , InterPro:IN-FAMILY:IPR018487 , InterPro:IN-FAMILY:IPR021158 , InterPro:IN-FAMILY:IPR021190 , InterPro:IN-FAMILY:IPR021805 , InterPro:IN-FAMILY:IPR024079 , PDB:Structure:1BQQ , PDB:Structure:1BUV , PDB:Structure:3C7X , PDB:Structure:3MA2 , Pfam:IN-FAMILY:PF00045 , Pfam:IN-FAMILY:PF00413 , Pfam:IN-FAMILY:PF01471 , Pfam:IN-FAMILY:PF11857 , Prints:IN-FAMILY:PR00138 , Prosite:IN-FAMILY:PS00024 , Prosite:IN-FAMILY:PS00142 , Prosite:IN-FAMILY:PS00546 , Prosite:IN-FAMILY:PS51642 , Smart:IN-FAMILY:SM00120 , Smart:IN-FAMILY:SM00235
Enzymatic reaction of: matrix metalloproteinase
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
The reaction is physiologically favored in the direction shown.
Liu10c: Liu G, Atteridge CL, Wang X, Lundgren AD, Wu JD (2010). "The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases." J Immunol 184(7);3346-50. PMID: 20208009
Mignon95: Mignon C, Okada A, Mattei MG, Basset P (1995). "Assignment of the human membrane-type matrix metalloproteinase (MMP14) gene to 14q11-q12 by in situ hybridization." Genomics 28(2);360-1. PMID: 8530054
Sato97: Sato H, Tanaka M, Takino T, Inoue M, Seiki M (1997). "Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization." Genomics 39(3);412-3. PMID: 9119382
Segarra07: Segarra M, Garcia-Martinez A, Sanchez M, Hernandez-Rodriguez J, Lozano E, Grau JM, Cid MC (2007). "Gelatinase expression and proteolytic activity in giant-cell arteritis." Ann Rheum Dis 66(11);1429-35. PMID: 17502363
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