MetaCyc Enzyme: matrix metalloproteinase-14

Gene: MMP14 Accession Number: HS08195 (MetaCyc)

Synonyms: MT1-MMP, MTMMP1, MMP-X1, membrane-type matrix metalloproteinase 1, membrane-type-1 matrix metalloproteinase, MMP-14, MT-MMP 1, MT1MMP

Species: Homo sapiens

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases, but some are membrane bound. The membrane-bound MMPs contain a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.

MMP14 is a member of the membrane-type MMP (MT-MMP) subfamily. This protein activates progelatinase (MMP2), and may trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface [Segarra07].

It was reported that MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases [Liu10].

The gene has been localized to human chromosome 14q12.2 [Mignon95, Sato97].

Map Position: [17,093,094 -> 17,104,104]

Unification Links: ArrayExpress:P50281 , DIP:DIP-35111N , Entrez-gene:4323 , Mint:MINT-246780 , PhosphoSite:P50281 , Pride:P50281 , Protein Model Portal:P50281 , SMR:P50281 , String:9606.ENSP00000308208 , UniProt:P50281

Relationship Links: InterPro:IN-FAMILY:IPR000585 , InterPro:IN-FAMILY:IPR001818 , InterPro:IN-FAMILY:IPR002477 , InterPro:IN-FAMILY:IPR006026 , InterPro:IN-FAMILY:IPR016293 , InterPro:IN-FAMILY:IPR018486 , InterPro:IN-FAMILY:IPR018487 , InterPro:IN-FAMILY:IPR021158 , InterPro:IN-FAMILY:IPR021190 , InterPro:IN-FAMILY:IPR021805 , InterPro:IN-FAMILY:IPR024079 , InterPro:IN-FAMILY:IPR028693 , Panther:IN-FAMILY:PTHR10201:SF24 , PDB:Structure:1BQQ , PDB:Structure:1BUV , PDB:Structure:3C7X , PDB:Structure:3MA2 , Pfam:IN-FAMILY:PF00045 , Pfam:IN-FAMILY:PF00413 , Pfam:IN-FAMILY:PF01471 , Pfam:IN-FAMILY:PF11857 , Prints:IN-FAMILY:PR00138 , Prosite:IN-FAMILY:PS00024 , Prosite:IN-FAMILY:PS00142 , Prosite:IN-FAMILY:PS00546 , Prosite:IN-FAMILY:PS51642 , Smart:IN-FAMILY:SM00120 , Smart:IN-FAMILY:SM00235

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 23-Sep-2010 by Caspi R , SRI International

Enzymatic reaction of: matrix metalloproteinase

EC Number:

a collagenase + H2O <=> a procollagenase + a peptide

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.


Schematic showing introns, exons and/or isoforms of MMP14


Liu10: Liu G, Atteridge CL, Wang X, Lundgren AD, Wu JD (2010). "The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases." J Immunol 184(7);3346-50. PMID: 20208009

Mignon95: Mignon C, Okada A, Mattei MG, Basset P (1995). "Assignment of the human membrane-type matrix metalloproteinase (MMP14) gene to 14q11-q12 by in situ hybridization." Genomics 28(2);360-1. PMID: 8530054

Sato97: Sato H, Tanaka M, Takino T, Inoue M, Seiki M (1997). "Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization." Genomics 39(3);412-3. PMID: 9119382

Segarra07: Segarra M, Garcia-Martinez A, Sanchez M, Hernandez-Rodriguez J, Lozano E, Grau JM, Cid MC (2007). "Gelatinase expression and proteolytic activity in giant-cell arteritis." Ann Rheum Dis 66(11);1429-35. PMID: 17502363

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 6, 2015, biocyc13.