Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: N-acylsphingosine amidohydrolase 1

Gene: Asah1 Accession Number: MGI:1277124 (MetaCyc)

Species: Mus musculus

Map Position: [42,425,551 <- 42,460,127] (32.43 centisomes)

Unification Links: ArrayExpress:Q9WV54 , MGI:1277124 , Mint:MINT-4088419 , PhosphoSite:Q9WV54 , Pride:Q9WV54 , Protein Model Portal:Q9WV54 , String:Q9WV54 , UniProt:Q9WV54

Relationship Links: Entrez-Nucleotide:PART-OF:11886 , InterPro:IN-FAMILY:IPR003199 , InterPro:IN-FAMILY:IPR016699 , Pfam:IN-FAMILY:PF02275

Gene-Reaction Schematic: ?

GO Terms:

Molecular Function: GO:0016787 - hydrolase activity
GO:0017040 - ceramidase activity

Gene Class: UNCLASSIFIED


Enzymatic reaction of: N-acylsphingosine amidohydrolase

EC Number: 3.5.1.23

an N-acylsphingosine + H2O <=> sphingosine + a fatty acid

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: sphingosine and sphingosine-1-phosphate metabolism


References

Li02: Li CM, Park JH, Simonaro CM, He X, Gordon RE, Friedman AH, Ehleiter D, Paris F, Manova K, Hepbildikler S, Fuks Z, Sandhoff K, Kolesnick R, Schuchman EH, Hepbiloikler S (2002). "Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes." Genomics 79(2);218-24. PMID: 11829492


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.