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MetaCyc Enzyme: N-acylsphingosine amidohydrolase 1

Gene: Asah1 Accession Number: MGI:1277124 (MetaCyc)

Species: Mus musculus

Map Position: [42,425,551 <- 42,460,127] (32.43 centisomes)

Unification Links: ArrayExpress:Q9WV54 , MGI:1277124 , Mint:MINT-4088419 , PhosphoSite:Q9WV54 , Pride:Q9WV54 , Protein Model Portal:Q9WV54 , String:Q9WV54 , UniProt:Q9WV54

Relationship Links: Entrez-Nucleotide:PART-OF:11886 , InterPro:IN-FAMILY:IPR016699 , InterPro:IN-FAMILY:IPR029130 , InterPro:IN-FAMILY:IPR029132 , Pfam:IN-FAMILY:PF02275 , Pfam:IN-FAMILY:PF15508

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Molecular Function: GO:0016787 - hydrolase activity
GO:0017040 - ceramidase activity

Gene Class: UNCLASSIFIED


Enzymatic reaction of: N-acylsphingosine amidohydrolase

EC Number: 3.5.1.23

a (4E)-sphing-4-enine ceramide + H2O <=> sphingosine + a fatty acid

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: sphingosine and sphingosine-1-phosphate metabolism


References

Li02c: Li CM, Park JH, Simonaro CM, He X, Gordon RE, Friedman AH, Ehleiter D, Paris F, Manova K, Hepbildikler S, Fuks Z, Sandhoff K, Kolesnick R, Schuchman EH, Hepbiloikler S (2002). "Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes." Genomics 79(2);218-24. PMID: 11829492


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Sep 3, 2015, biocyc12.