Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: proline dehydrogenase 1

Gene: POX1 Accession Numbers: AT3G30775 (MetaCyc), At3g30775

Synonyms: PRODH1, ERD5

Species: Arabidopsis thaliana col

Summary:
Arabidopsis has two functional genes encoding proline dehydrogenase - POX1 and POX2 [Funck10]. The two proteins have non-redundant, although partially overlapping physiological functions. Proline dehydrogenase 1 appears to be the dominant isoform under most conditions and in most tissues, while proline dehydrogenase 2 is specifically upregulated during salt stress (when POX1 is repressed) [Funck10].

The POX1 gene expression was repressed under dehydration conditions and induced upon rehydration [Kiyosue96].

Locations: mitochondrion

Molecular Weight of Polypeptide: 54.956 kD (from nucleotide sequence)

Unification Links: Entrez-gene:822833 , Mint:MINT-8065297 , PhylomeDB:P92983 , Pride:P92983 , Protein Model Portal:P92983 , SMR:P92983 , String:3702.AT3G30775.1-P , TAIR:At3g30775 , UniProt:P92983

Relationship Links: InterPro:IN-FAMILY:IPR002872 , InterPro:IN-FAMILY:IPR015659 , Panther:IN-FAMILY:PTHR13914 , Pfam:IN-FAMILY:PF01619

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005739 - mitochondrion [Kiyosue96]

Credits:
Revised 16-Jun-2010 by Caspi R , SRI International


Enzymatic reaction of: proline dehydrogenase

EC Number: 1.5.5.2

In Pathways: superpathway of citrulline metabolism , L-Nδ-acetylornithine biosynthesis , proline degradation

Cofactors or Prosthetic Groups: FAD


References

Funck10: Funck D, Eckard S, Muller G (2010). "Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis." BMC Plant Biol 10;70. PMID: 20403182

Kiyosue96: Kiyosue T, Yoshiba Y, Yamaguchi-Shinozaki K, Shinozaki K (1996). "A nuclear gene encoding mitochondrial proline dehydrogenase, an enzyme involved in proline metabolism, is upregulated by proline but downregulated by dehydration in Arabidopsis." Plant Cell 8(8);1323-35. PMID: 8776899


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, BIOCYC13A.