MetaCyc Enzyme: proline dehydrogenase 1

Gene: POX1 Accession Numbers: AT3G30775 (MetaCyc), At3g30775

Synonyms: PRODH1, ERD5

Species: Arabidopsis thaliana col

Arabidopsis has two functional genes encoding proline dehydrogenase - POX1 and POX2 [Funck10]. The two proteins have non-redundant, although partially overlapping physiological functions. Proline dehydrogenase 1 appears to be the dominant isoform under most conditions and in most tissues, while proline dehydrogenase 2 is specifically upregulated during salt stress (when POX1 is repressed) [Funck10].

The POX1 gene expression was repressed under dehydration conditions and induced upon rehydration [Kiyosue96].

Locations: mitochondrion

Molecular Weight of Polypeptide: 54.956 kD (from nucleotide sequence)

Unification Links: Entrez-gene:822833 , Mint:MINT-8065297 , PhylomeDB:P92983 , Pride:P92983 , Protein Model Portal:P92983 , SMR:P92983 , String:3702.AT3G30775.1-P , TAIR:At3g30775 , UniProt:P92983

Relationship Links: InterPro:IN-FAMILY:IPR002872 , InterPro:IN-FAMILY:IPR015659 , InterPro:IN-FAMILY:IPR029041 , Panther:IN-FAMILY:PTHR13914 , Pfam:IN-FAMILY:PF01619

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [L-proline + an electron-transfer quinone[inner membrane] → (S)-1-pyrroline-5-carboxylate + an electron-transfer quinol[inner membrane] + H+] (
i1: L-proline[in] + a ubiquinone[membrane] → (S)-1-pyrroline-5-carboxylate[in] + an ubiquinol[membrane] + H+[in] (

i2: L-proline + a ubiquinone[inner membrane] → (S)-1-pyrroline-5-carboxylate + an ubiquinol[inner membrane] + H+ (

GO Terms:

Cellular Component: GO:0005739 - mitochondrion [Kiyosue96]

Revised 16-Jun-2010 by Caspi R , SRI International

Enzymatic reaction of: proline dehydrogenase

EC Number:

Transport reaction diagram for proline dehydrogenase

In Pathways: superpathway of L-citrulline metabolism , L-Nδ-acetylornithine biosynthesis , L-proline degradation

Cofactors or Prosthetic Groups: FAD


Funck10: Funck D, Eckard S, Muller G (2010). "Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis." BMC Plant Biol 10;70. PMID: 20403182

Kiyosue96: Kiyosue T, Yoshiba Y, Yamaguchi-Shinozaki K, Shinozaki K (1996). "A nuclear gene encoding mitochondrial proline dehydrogenase, an enzyme involved in proline metabolism, is upregulated by proline but downregulated by dehydration in Arabidopsis." Plant Cell 8(8);1323-35. PMID: 8776899

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, BIOCYC14A.