|Gene:||AF1794||Accession Number: G-3884 (MetaCyc)|
Species: Archaeoglobus fulgidus
Subunit composition of
inositol-1-phosphate synthase = [AF1794]4
inositol-1-phosphate synthase subunit = AF1794
The Archaeoglobus fulgidus inositol-1-phosphate synthase (IPS) gene was overexpressed in Escherichia coli. This archaeal enzyme, with the highest activity at its optimum growth temperature among all IPS reported, is extremely heat stable. The most unique feature of the Archaeoglobus fulgidus enzyme is that it absolutely requires divalent metal ions for activity, while NH4+ (a critical activator for all the other characterized IPS enzymes) has no effect. These properties suggested that this archaeal IPS is a class II aldolase [Chen00c].
Molecular Weight of Polypeptide: 44 kD (experimental) [Chen00c ]
Molecular Weight of Multimer: 168 kD (experimental) [Chen00c]
Relationship Links: Entrez-Nucleotide:PART-OF:AE000979 , InterPro:IN-FAMILY:IPR002587 , InterPro:IN-FAMILY:IPR013021 , InterPro:IN-FAMILY:IPR016040 , Panther:IN-FAMILY:PTHR11510 , PDB:Structure:1U1I , PDB:Structure:3QVS , PDB:Structure:3QVT , PDB:Structure:3QVW , PDB:Structure:3QVX , PDB:Structure:3QW2 , Pfam:IN-FAMILY:PF01658 , Pfam:IN-FAMILY:PF07994
Instance reaction of [D-glucopyranose 6-phosphate → 1D-myo-inositol 3-monophosphate] (18.104.22.168):
|MultiFun Terms:||metabolism → biosynthesis of macromolecules (cellular constituents) → phospholipid|
Enzymatic reaction of: inositol-1-phosphate synthase
EC Number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
The reaction is favored in the direction shown.
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