Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: adenylosuccinate synthetase

Gene: ade12 Accession Number: G-462 (MetaCyc)

Species: Saccharomyces cerevisiae

Subunit composition of adenylosuccinate synthetase = [Ade12]2

Molecular Weight of Polypeptide: 48.148 kD (from nucleotide sequence) [Bairoch93a ]

Unification Links: DIP:DIP-4286N , Mint:MINT-560386 , ModBase:P80210 , Protein Model Portal:P80210 , SMR:P80210 , String:4932.YNL220W , Swiss-Model:P80210 , UniProt:P80210

Relationship Links: InterPro:IN-FAMILY:IPR001114 , InterPro:IN-FAMILY:IPR018220 , InterPro:IN-FAMILY:IPR027417 , Panther:IN-FAMILY:PTHR11846 , Pfam:IN-FAMILY:PF00709 , Prosite:IN-FAMILY:PS00513 , Prosite:IN-FAMILY:PS01266 , Smart:IN-FAMILY:SM00788

Gene-Reaction Schematic: ?


Enzymatic reaction of: adenylosuccinate synthetase

Synonyms: IMP-aspartate ligase, AS synthetase, ADSS, AMPSase

EC Number: 6.3.4.4

L-aspartate + IMP + GTP <=> adenylo-succinate + GDP + phosphate + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is physiologically favored in the direction shown.

In Pathways: superpathway of purine nucleotides de novo biosynthesis I , superpathway of adenosine nucleotides de novo biosynthesis I

Summary:
Adenylosuccinate synthetase catalyzes the first reaction in the synthesis of AMP [Ryzhova98, Lipps99].

Cofactors or Prosthetic Groups: Mg2+ [Comment 1]

Inhibitors (Competitive): GDP [Comment 2] , GMP [Comment 3] , hydroxylamine [Comment 4]

Inhibitors (Unknown Mechanism): ATP [Comment 5] , ADP [Ryzhova98] , AMP [Comment 6] , Zn2+ [Ryzhova98] , Mn2+ [Ryzhova98] , chloride [Lipps99]

Primary Physiological Regulators of Enzyme Activity: ATP , GDP , GMP


References

Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Lipps99: Lipps G, Krauss G (1999). "Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the recombinant protein." Biochem J 1999;341 ( Pt 3);537-43. PMID: 10417315

Ryzhova98: Ryzhova TA, Andreichuk YV, Domkin VD (1998). "Adenylosuccinate synthetase of the yeast Saccharomyces cerevisiae: purification and properties." Biochemistry (Mosc) 1998;63(6);650-6. PMID: 9668204


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14B.