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MetaCyc Enzyme: adenylosuccinate synthetase

Gene: ade12 Accession Number: G-462 (MetaCyc)

Species: Saccharomyces cerevisiae

Subunit composition of adenylosuccinate synthetase = [Ade12]2

Molecular Weight of Polypeptide: 48.148 kD (from nucleotide sequence) [Bairoch93a ]

Unification Links: DIP:DIP-4286N , Mint:MINT-560386 , ModBase:P80210 , Protein Model Portal:P80210 , SMR:P80210 , String:4932.YNL220W , Swiss-Model:P80210 , UniProt:P80210

Relationship Links: InterPro:IN-FAMILY:IPR001114 , InterPro:IN-FAMILY:IPR018220 , InterPro:IN-FAMILY:IPR027417 , Panther:IN-FAMILY:PTHR11846 , Pfam:IN-FAMILY:PF00709 , Prosite:IN-FAMILY:PS00513 , Prosite:IN-FAMILY:PS01266 , Smart:IN-FAMILY:SM00788

Gene-Reaction Schematic: ?

Gene-Reaction Schematic


Enzymatic reaction of: adenylosuccinate synthetase

Synonyms: IMP-aspartate ligase, AS synthetase, ADSS, AMPSase

EC Number: 6.3.4.4

L-aspartate + IMP + GTP <=> adenylo-succinate + GDP + phosphate + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: superpathway of purine nucleotides de novo biosynthesis I , superpathway of adenosine nucleotides de novo biosynthesis I

Summary:
Adenylosuccinate synthetase catalyzes the first reaction in the synthesis of AMP [Ryzhova98, Lipps99].

Cofactors or Prosthetic Groups: Mg2+ [Comment 1]

Inhibitors (Competitive): GDP [Comment 2] , GMP [Comment 3] , hydroxylamine [Comment 4]

Inhibitors (Unknown Mechanism): ATP [Comment 5] , ADP [Ryzhova98] , AMP [Comment 6] , Zn2+ [Ryzhova98] , Mn2+ [Ryzhova98] , chloride [Lipps99]

Primary Physiological Regulators of Enzyme Activity: ATP , GDP , GMP


References

Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Lipps99: Lipps G, Krauss G (1999). "Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the recombinant protein." Biochem J 1999;341 ( Pt 3);537-43. PMID: 10417315

Ryzhova98: Ryzhova TA, Andreichuk YV, Domkin VD (1998). "Adenylosuccinate synthetase of the yeast Saccharomyces cerevisiae: purification and properties." Biochemistry (Mosc) 1998;63(6);650-6. PMID: 9668204


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Apr 1, 2015, biocyc13.