Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: ribitol dehydrogenase

Gene: rbtD Accession Number: G-9462 (MetaCyc)

Synonyms: ribitol 2-dehydrogenase

Species: Enterobacter aerogenes

Subunit composition of ribitol dehydrogenase = [RbtD]4
         ribitol dehydrogenase subunit = RbtD

Summary:
The native molecular mass was determined by sedimentation equilibrium analysis [Taylor74].
The subunit molecular mass was determined by SDS-PAGE [Taylor74].

Molecular Weight of Polypeptide: 26.514 kD (from nucleotide sequence), 27 kD (experimental) [Taylor74 ]

Molecular Weight of Multimer: 118 kD (experimental) [Taylor74]

Unification Links: Protein Model Portal:P00335 , UniProt:P00335

Relationship Links: Entrez-Nucleotide:PART-OF:M25606 , InterPro:IN-FAMILY:IPR002198 , InterPro:IN-FAMILY:IPR002347 , InterPro:IN-FAMILY:IPR016040 , InterPro:IN-FAMILY:IPR020904 , Pfam:IN-FAMILY:PF00106 , Prints:IN-FAMILY:PR00081 , Prosite:IN-FAMILY:PS00061

Gene-Reaction Schematic: ?


Enzymatic reaction of: ribitol dehydrogenase

EC Number: 1.1.1.56

ribitol + NAD+ <=> D-ribulose + NADH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: superpathway of pentose and pentitol degradation , ribitol degradation

Summary:
NAD+ protected the enzyme against inhibition by o-phenanthroline, diethyldithiocarbamate, mercuric chloride, and p-chloromercuribenzoate [Taylor74].

Inhibitors (Competitive): dithiothreitol [Taylor74] , 2-mercaptoethanol [Taylor74]

Inhibitors (Unknown Mechanism): Hg2+ [Taylor74] , diethyldithiocarbamate [Taylor74] , o-phenanthroline [Taylor74] , p-chloromercuribenzoate [Taylor74]


References

Taylor74: Taylor SS, Rigby PW, Hartley BS (1974). "Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure." Biochem J 141(3);693-700. PMID: 4618776


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC14A.