|Gene:||gdh||Accession Number: G-10249 (MetaCyc)|
Species: Neurospora crassa
Subunit composition of
glutamate dehydrogenase (NADP+) = [Gdh]6
glutamate dehydrogenase subunit = Gdh
Different species of yeasts and filamentous fungi, including Neurospora crassa, possess two glutamate dehydrogenases. One depends on NADP and has a biosynthetic role, whereas the other depends on NAD and catabolizes glutamate. Like the vertebrate enzymes, glutamate dehydrogenase (NADP+) of Neurospora crassa is a homohexamer, composed of 48.8 kDa subunits [Blumenthal73].
Unlike the vertebrate enzyme, the enzyme from Neurospora crassa exhibits very weak, if any, allosteric effects.
Gene Citations: [Kinnaird83]
Molecular Weight of Polypeptide: 48.853 kD (from nucleotide sequence), 48.8 kD (experimental) [Blumenthal73 ]
Molecular Weight of Multimer: 288.4 kD (experimental) [Blumenthal73]
Relationship Links: Entrez-Nucleotide:PART-OF:K01409 , InterPro:IN-FAMILY:IPR006095 , InterPro:IN-FAMILY:IPR006096 , InterPro:IN-FAMILY:IPR006097 , InterPro:IN-FAMILY:IPR014362 , InterPro:IN-FAMILY:IPR016040 , Pfam:IN-FAMILY:PF00208 , Pfam:IN-FAMILY:PF02812 , Prints:IN-FAMILY:PR00082 , Prosite:IN-FAMILY:PS00074 , Smart:IN-FAMILY:SM00839
Enzymatic reaction of: glutamate dehydrogenase
Synonyms: NADP-dependent glutamate dehydrogenase
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
This reaction is reversible.
In Pathways: nitrate reduction V (assimilatory)
Blumenthal73: Blumenthal KM, Smith EL (1973). "Nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase of Neurospora. I. Isolation, subunits, amino acid composition, sulfhydryl groups, and identification of a lysine residue reactive with pyridoxal phosphate and N-ethylmaleimide." J Biol Chem 248(17);6002-8. PMID: 4146914
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