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MetaCyc Enzyme: mannokinase

Species: Escherichia coli K-12 substr. MG1655

Summary:
Mannokinase activity in E. coli is constitutively expressed; the enzyme can also phosphorylate fructose and to a lesser extent glucosamine, D-glucose and 2-deoxyglucose [Sebastian67, Sebastian72].

The gene encoding mannokinase is unknown.

Gene-Reaction Schematic

Gene-Reaction Schematic

Credits:
Imported from EcoCyc 30-Sep-2015 by Paley S, SRI International


Enzymatic reaction of: mannokinase

Inferred from experiment

Synonyms: ATP:D-mannose 6-phosphotransferase

EC Number: 2.7.1.7

D-mannopyranose + ATP → D-mannopyranose 6-phosphate + ADP + H+

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

Alternative Substrates for D-mannopyranose: D-fructose [Sebastian67, Sebastian72]
Alternative Substrates for ATP: ITP [Sebastian72]

Credits:
Imported from EcoCyc 30-Sep-2015 by Paley S, SRI International

Cofactors or Prosthetic Groups: Mg2+ [Sebastian72]

Inhibitors (Competitive): D-mannosamine [Sebastian72]Kinetic Parameters:
Substrate Km (μM) Citations
ATP 200.0 [Sebastian72]
D-mannopyranose 200.0 [Sebastian72]

pH(opt): 7.5-8.5 [Sebastian72]


References

Sebastian67: Sebastian J, Asensio C (1967). "Identification of mannokinase in Escherichia coli." Biochem Biophys Res Commun 28(2);197-202. PMID: 5342371

Sebastian72: Sebastian J, Asensio C (1972). "Purification and properties of the mannokinase from Escherichia coli." Arch Biochem Biophys 151(1);227-33. PMID: 4557975


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Feb 6, 2016, biocyc14.