Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: mannokinase

Species: Escherichia coli K-12 substr. MG1655

Summary:
Mannokinase activity in E. coli is constitutively expressed; the enzyme can also phosphorylate fructose and to a lesser extent glucosamine, D-glucose and 2-deoxyglucose [Sebastian67, Sebastian72].

The gene encoding mannokinase is unknown.

Gene-Reaction Schematic: ?

Credits:
Imported from EcoCyc 16-Sep-2014 by Paley S , SRI International


Enzymatic reaction of: mannokinase

Synonyms: ATP:D-mannose 6-phosphotransferase

EC Number: 2.7.1.7

D-mannopyranose + ATP <=> α-D-mannose 6-phosphate + ADP + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the direction shown.

Alternative Substrates for D-mannopyranose: D-fructose [Sebastian67 , Sebastian72 ]

Alternative Substrates for ATP: ITP [Sebastian72 ]

Credits:
Imported from EcoCyc 16-Sep-2014 by Paley S , SRI International

Cofactors or Prosthetic Groups: Mg2+ [Sebastian72]

Inhibitors (Competitive): D-mannosamine [Sebastian72]

Kinetic Parameters:

Substrate
Km (μM)
Citations
ATP
200.0
[Sebastian72]
D-mannopyranose
200.0
[Sebastian72]

pH(opt): 7.5-8.5 [Sebastian72]


References

Sebastian67: Sebastian J, Asensio C (1967). "Identification of mannokinase in Escherichia coli." Biochem Biophys Res Commun 28(2);197-202. PMID: 5342371

Sebastian72: Sebastian J, Asensio C (1972). "Purification and properties of the mannokinase from Escherichia coli." Arch Biochem Biophys 151(1);227-33. PMID: 4557975


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc13.