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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
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MetaCyc Enzyme: mannokinase

Species: Escherichia coli K-12 substr. MG1655

Summary:
Mannokinase activity in E. coli is constitutively expressed; the enzyme can also phosphorylate fructose and to a lesser extent glucosamine, D-glucose and 2-deoxyglucose [Sebastian67, Sebastian72].

The gene encoding mannokinase is unknown.

Gene-Reaction Schematic: ?

Credits:
Imported from EcoCyc 16-Sep-2014 by Paley S , SRI International


Enzymatic reaction of: mannokinase

Synonyms: ATP:D-mannose 6-phosphotransferase

EC Number: 2.7.1.7

D-mannopyranose + ATP <=> α-D-mannose 6-phosphate + ADP + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the direction shown.

Alternative Substrates for D-mannopyranose: D-fructose [Sebastian67 , Sebastian72 ]

Alternative Substrates for ATP: ITP [Sebastian72 ]

Credits:
Imported from EcoCyc 16-Sep-2014 by Paley S , SRI International

Cofactors or Prosthetic Groups: Mg2+ [Sebastian72]

Inhibitors (Competitive): D-mannosamine [Sebastian72]

Kinetic Parameters:

Substrate
Km (μM)
Citations
ATP
200.0
[Sebastian72]
D-mannopyranose
200.0
[Sebastian72]

pH(opt): 7.5-8.5 [Sebastian72]


References

Sebastian67: Sebastian J, Asensio C (1967). "Identification of mannokinase in Escherichia coli." Biochem Biophys Res Commun 28(2);197-202. PMID: 5342371

Sebastian72: Sebastian J, Asensio C (1972). "Purification and properties of the mannokinase from Escherichia coli." Arch Biochem Biophys 151(1);227-33. PMID: 4557975


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14A.