This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Generation of Precursor Metabolites and Energy → Pentose Phosphate Pathways|
Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655
The pentose phosphate pathway is an alternative way of oxidizing glucose, and in this pathway the oxidation is coupled to NADPH synthesis. As a result, the pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions. The pentose phosphate pathway is also important for the conversion of hexoses to pentoses [Zubay83] .
About This Pathway
The pentose phosphate pathway is one of the three essential pathways of central metabolism. It supplies three of Escherichia coli's 13 precursor metabolites (compounds needed for the biosyntheses): D-ribose 5-phosphate, D-sedoheptulose 7-phosphate, and D-erythrose 4-phosphate. Regardless of the carbon source upon which Escherichia coli is growing, some carbon must flow through the pentose phosphate pathway to meet the cell's requirements for these metabolites. In addition this pathway is an important source of NADPH, which is also needed for biosyntheses. The pathway begins with one intermediate of glycolysis, β-D-glucose 6-phosphate, and ends with the formation of two others, β-D-fructofuranose 6-phosphate and D-glyceraldehyde 3-phosphate.
For convenience, the pentose phosphate pathway is commonly divided into its preliminary oxidative portion, in which β-D-glucose 6-phosphate is oxidized to D-ribulose 5-phosphate, and its subsequent non-oxidative portion in which through a series of transaldolase and transketolase reactions, D-ribulose 5-phosphate is converted into β-D-fructofuranose 6-phosphate and D-glyceraldehyde 3-phosphate.
Unification Links: EcoCyc:NONOXIPENT-PWY
Asztalos07: Asztalos P, Parthier C, Golbik R, Kleinschmidt M, Hubner G, Weiss MS, Friedemann R, Wille G, Tittmann K (2007). "Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate." Biochemistry 46(43);12037-52. PMID: 17914867
Aucamp08: Aucamp JP, Martinez-Torres RJ, Hibbert EG, Dalby PA (2008). "A microplate-based evaluation of complex denaturation pathways: structural stability of Escherichia coli transketolase." Biotechnol Bioeng 99(6);1303-10. PMID: 17969139
Butland05: Butland G, Peregrin-Alvarez JM, Li J, Yang W, Yang X, Canadien V, Starostine A, Richards D, Beattie B, Krogan N, Davey M, Parkinson J, Greenblatt J, Emili A (2005). "Interaction network containing conserved and essential protein complexes in Escherichia coli." Nature 433(7025);531-7. PMID: 15690043
Chandran03: Chandran SS, Yi J, Draths KM, von Daeniken R, Weber W, Frost JW (2003). "Phosphoenolpyruvate availability and the biosynthesis of shikimic acid." Biotechnol Prog 19(3);808-14. PMID: 12790643
David70: David J, Wiesmeyer H (1970). "Regulation of ribose metabolism in Escherichia coli. II. Evidence for two ribose-5-phosphate isomerase activities." Biochim Biophys Acta 208(1);56-67. PMID: 4909663
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Domain07: Domain F, Bina XR, Levy SB (2007). "Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR." Mol Microbiol 66(2);383-94. PMID: 17850260
Essenberg75: Essenberg MK, Cooper RA (1975). "Two ribose-5-phosphate isomerases from Escherichia coli K12: partial characterisation of the enzymes and consideration of their possible physiological roles." Eur J Biochem 55(2);323-32. PMID: 1104357
Follstad98: Follstad BD, Stephanopoulos G (1998). "Effect of reversible reactions on isotope label redistribution--analysis of the pentose phosphate pathway." Eur J Biochem 252(3);360-71. PMID: 9546650
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