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MetaCyc Pathway: L-sorbose degradation
Inferred from experiment

Pathway diagram: L-sorbose degradation

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: L-sorbose metabolism

Superclasses: Degradation/Utilization/AssimilationCarbohydrates DegradationSugars Degradation

Some taxa known to possess this pathway include : Klebsiella pneumoniae

Expected Taxonomic Range: Bacteria , Viridiplantae

Klebsiella pneumoniae metabolizes L-sorbose to D-fructose-6-phosphate, which then enters glycolysis. L-Sorbose is transported into the cell, phosphorylated, and then converted to D-fructose-6-phosphate by two soluble enzymes. [Sprenger84]


Sprenger84: Sprenger GA, Lengeler JW (1984). "L-Sorbose metabolism in Klebsiella pneumoniae and Sor+ derivatives of Escherichia coli K-12 and chemotaxis toward sorbose." J Bacteriol 1984;157(1);39-45. PMID: 6361004

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

BRENDA14: BRENDA team (2014). Imported from BRENDA version existing on Aug 2014.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lengeler75: Lengeler J (1975). "Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping." J Bacteriol 1975;124(1);26-38. PMID: 1100602

Novotny84: Novotny MJ, Reizer J, Esch F, Saier MH (1984). "Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli." J Bacteriol 1984;159(3);986-90. PMID: 6384188

Roux06: Roux C, Salmon L, Verchere-Beaur C (2006). "Preliminary studies on the inhibition of D-sorbitol-6-phosphate 2-dehydrogenase from Escherichia coli with substrate analogues." J Enzyme Inhib Med Chem 21(2);187-92. PMID: 16791965

Svensater92: Svensater G, Edwardsson S, Kalfas S (1992). "Purification and properties of sorbitol-6-phosphate dehydrogenase from oral streptococci." Oral Microbiol Immunol 1992;7(3);148-54. PMID: 1408350

Yamada87: Yamada M, Saier MH (1987). "Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon." J Biol Chem 1987;262(12);5455-63. PMID: 3553176

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Jan 2, 2002, biocyc12.