This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Synonyms: vitamin B6 salvage I
|Superclasses:||Biosynthesis → Cofactors, Prosthetic Groups, Electron Carriers Biosynthesis → Vitamins Biosynthesis → Vitamin B6 Biosynthesis|
Pyridoxal 5'-phosphate (PLP) , a coenzyme for many enzymes that participate in amino acid and glycogen metabolism, can be synthesized de novo and by salvage pathways from pyridoxal, pyroxidine and pyridoxamine that might be present in the environment.
In this pathway PLP is synthesized by a salvage pathway from pyridoxal, pyroxidine and pyridoxamine, which are taken up from the environment and utilized.
Yang98a: Yang Y, Tsui HC, Man TK, Winkler ME (1998). "Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12." J Bacteriol 1998;180(7);1814-21. PMID: 9537380
Di98a: Di Salvo M, Yang E, Zhao G, Winkler ME, Schirch V (1998). "Expression, purification, and characterization of recombinant Escherichia coli pyridoxine 5'-phosphate oxidase." Protein Expr Purif 1998;13(3);349-56. PMID: 9693059
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
diSalvo02: di Salvo ML, Ko TP, Musayev FN, Raboni S, Schirch V, Safo MK (2002). "Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase." J Mol Biol 315(3);385-97. PMID: 11786019
diSalvo03: di Salvo ML, Safo MK, Musayev FN, Bossa F, Schirch V (2003). "Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase." Biochim Biophys Acta 1647(1-2);76-82. PMID: 12686112
Gonzalez07: Gonzalez E, Danehower D, Daub ME (2007). "Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway." Plant Physiol 145(3);985-96. PMID: 17873088
Hanna97: Hanna MC, Turner AJ, Kirkness EF (1997). "Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor." J Biol Chem 272(16);10756-60. PMID: 9099727
Kanellis07: Kanellis P, Gagliardi M, Banath JP, Szilard RK, Nakada S, Galicia S, Sweeney FD, Cabelof DC, Olive PL, Durocher D (2007). "A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions." PLoS Genet 3(8);e134. PMID: 17696614
LopezCampistrou05: Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ (2005). "Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth." Mol Cell Proteomics 4(8);1205-9. PMID: 15911532
Loubbardi95: Loubbardi A, Marcireau C, Karst F, Guilloton M (1995). "Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase." J Bacteriol 177(7);1817-23. PMID: 7896706
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